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Drug: Tamoxifen
Nutrition: Calcium
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Total 30 results found since Jan 2013.
RNA interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction
CONCLUSIONS: Our results confirm the translational potential of RUNX1 as a novel therapeutic target in myocardial infarction, with wider opportunities for use across a range of cardiac diseases where RUNX1 drives adverse cardiac remodelling.PMID:37433039 | DOI:10.1093/cvr/cvad107
Source: Cell Research - July 11, 2023 Category: Cytology Authors: Tamara P Martin Eilidh A MacDonald Ashley Bradley Holly Watson Priyanka Saxena Eva A Rog-Zielinska Anmar Raheem Simon Fisher Ali Ali Mohamed Elbassioni Ohood Almuzaini Catriona Booth Morna Campbell Alex Riddell Pawel Herzyk Karen Blyth Colin Nixon Lorena Source Type: research
Intestinal Vitamin D Receptor is Dispensable for Maintaining Adult Bone Mass in Mice with Adequate Calcium Intake
Endocrinology. 2023 Mar 24:bqad051. doi: 10.1210/endocr/bqad051. Online ahead of print.ABSTRACT1,25(OH)2D3-mediated intestinal calcium (Ca) absorption supplies Ca for proper bone mineralization during growth. We tested whether vitamin D receptor (VDR)-mediated 1,25(OH)2D3 signaling is critical for adult Ca absorption and bone by using mice with inducible Vdr gene knockout in the whole intestine (villin-CreERT2+/- x VDRf/f, WIK) or in the large intestine (CDX2-CreERT2+/-x VDRf/f, LIK). At 4-month-old, Vdr alleles were recombined (0.05 mg tamoxifen/g BW, i.p., 5-d) and mice were fed diets with either 0.5% (adequate) or 0.2% ...
Source: Endocrinology - March 24, 2023 Category: Endocrinology Authors: Heng Jiang Krittikan Chanpaisaeng Sylvia Christakos James C Fleet Source Type: research
Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis
CONCLUSIONS: We reveal, for the first time to our knowledge, that the canonical Hippo-Yap pathway plays a pivotal role in maintaining SAN homeostasis.PMID:36317529 | DOI:10.1161/CIRCULATIONAHA.121.058777
Source: Circulation - November 1, 2022 Category: Cardiology Authors: Mingjie Zheng Rich Gang Li Jia Song Xiaolei Zhao Li Tang Shannon Erhardt Wen Chen Bao H Nguyen Xiao Li Min Li Jianxin Wang Sylvia M Evans Vincent M Christoffels Na Li Jun Wang Source Type: research
Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2-Deficient Hearts
Conclusions: Exercise disproportionately affects Ca2+i homeostasis in PKP2-deficient hearts in a manner facilitated by stimulation of intracellular β-adrenergic receptors and hyperphosphorylation of phospholamban. These cellular changes create a proarrhythmogenic state that can be mitigated by ryanodine receptor 2 blockade. Our data unveil an arrhythmogenic mechanism for exercise-induced or catecholaminergic life-threatening arrhythmias in the setting of PKP2 deficit. We suggest that membrane-permeable β-blockers are potentially more efficient for patients with arrhythmogenic right ventricular cardiomyopathy, highlight t...
Source: Circulation - May 2, 2022 Category: Cardiology Authors: Chantal J M van Opbergen Navratan Bagwan Svetlana R Maurya Joon-Chul Kim Abigail N Smith Daniel J Blackwell Jeffrey N Johnston Bj örn C Knollmann Marina Cerrone Alicia Lundby Mario Delmar Source Type: research
Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis
Matrix Biol. 2021 Sep 8:S0945-053X(21)00083-4. doi: 10.1016/j.matbio.2021.08.002. Online ahead of print.ABSTRACTDysregulation of proteolytic enzymes has huge impact on epidermal homeostasis, which can result in severe pathological conditions such as fibrosis or Netherton syndrome. The metalloprotease meprin β was found to be upregulated in hyperproliferative skin diseases. AP-1 transcription factor complex has been reported to induce Mep1b expression. Since AP-1 and its subunit fos-related antigen 2 (fra-2) are associated with the onset and progression of psoriasis, we wanted to investigate if this could partially be attr...
Source: Matrix Biology - September 11, 2021 Category: Molecular Biology Authors: Florian Peters Sascha Rahn Marion Mengel Franka Scharfenberg Anna Otte Tomas Koudelka Erwin F Wagner F Thomas Wunderlich Michael Haase Ronald Naumann Andreas Tholey Christoph Becker-Pauly Source Type: research
