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Inducible generalized activation of hSTING-N154S expression in mice leads to lethal hypercytokinemia: a model for "cytokine storm"
J Leukoc Biol. 2023 Mar 1;113(3):326-333. doi: 10.1093/jleuko/qiac019.ABSTRACTExcessive levels of circulating proinflammatory mediators, known as "hypercytokinemia," that are generated by overwhelming immune system activation can lead to death due to critical organ failure and thrombotic events. Hypercytokinemia has been frequently associated with a variety of infectious and autoimmune diseases, with severe acute respiratory syndrome coronavirus 2 infection currently being the commonest cause, of what has been termed the cytokine storm. Among its various functions within the host, STING (stimulator of interferon genes) is ...
Source: Journal of Leukocyte Biology - March 2, 2023 Category: Hematology Authors: Gary R Martin Carolina Salazar Arcila Laura J Hallihan Teresa Scheidl-Yee Frank R Jirik Source Type: research

Novel transgenic mice with Cre-dependent co-expression of GFP and human ACE2: a safe tool for study of COVID-19 pathogenesis
Transgenic Res. 2021 Apr 14:1-13. doi: 10.1007/s11248-021-00249-8. Online ahead of print.ABSTRACTThe current coronavirus disease (COVID-19) pandemic remains one of the most serious public health problems. Increasing evidence shows that infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a very complex and multifaceted disease that requires detailed study. Nevertheless, experimental research on COVID-19 remains challenging due to the lack of appropriate animal models. Herein, we report novel humanized mice with Cre-dependent expression of hACE2, the main entry receptor of SARS-CoV-2. These mice ...
Source: Transgenic Research - April 15, 2021 Category: Genetics & Stem Cells Authors: Alexandra V Bruter Diana S Korshunova Marina V Kubekina Petr V Sergiev Anastasiia A Kalinina Leonid A Ilchuk Yuliya Yu Silaeva Eugenii N Korshunov Vladislav O Soldatov Alexey V Deykin Source Type: research

Estrogen and Androgen Receptor Inhibitors: Unexpected Allies in the Fight Against COVID-19
Cell Transplant. 2021 Jan-Dec;30:963689721991477. doi: 10.1177/0963689721991477.ABSTRACTTRANSLATIONAL RELEVANCE: No prophylactic treatments for COVID-19 have been clearly proven and found. In this pandemic context, cancer patients constitute a particularly fragile population that would benefit the best from such treatments, a present unmet need. TMPRSS2 is essential for COVID-19 replication cycle and it is under androgen control. Estrogen and androgen receptor dependent cues converge on TMPRSS2 regulation through different mechanisms of action that can be blocked by the use of hormonal therapies. We believe that there is e...
Source: Cell Transplantation - February 1, 2021 Category: Cytology Authors: Sara Bravaccini Eugenio Fonzi Michela Tebaldi Davide Angeli Giovanni Martinelli Fabio Nicolini Paola Parrella Massimiliano Mazza Source Type: research