Filtered By:
Source: Cancer Control
Drug: Tamoxifen
This page shows you your search results in order of date.
Order by Relevance | Date
Total 69 results found since Jan 2013.
Thyroid hormone enhances estrogen-mediated proliferation and cell cycle regulatory pathways in steroid receptor-positive breast Cancer
In this report, we show TH ± E2 ± tamoxifen inhibits cell cycle control signaling, reduces apoptosis, and enhances cell proliferation, tumor growth, tamoxifen resistance, and clonal expansion. Mechanistically these changes involve numerous genes and pathways, including critical cell cycle regulatory proteins and genes identified using various molecular methods. These studies facilitate a greater mechanistic understanding of the biological and molecular impact of TH on SR+ BC.PMID:37723865 | DOI:10.1080/15384101.2023.2249702
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Reema S Wahdan-Alaswad Susan M Edgerton Hyun Min Kim Aik Choon Tan Bryan R Haugen Bolin Liu Ann D Thor Source Type: research
Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds
Bioinformation. 2023 Jan 31;19(1):111-116. doi: 10.6026/97320630019111. eCollection 2023.ABSTRACTBeta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Tamoxifen used as control. Data shows that compounds 2, 4, and 6 exhibited comparably significant molecular interactions with the cancerous protein for further consideration.PMID:37720289 | PMC:PMC10504516 | DOI:10.6026/97320630019111
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Vipra Sharma Gayathri Rengasamy Surya Sekaran Kavitha Sankaran Vishnu Priya Veeraraghavan Rajalakshmanan Eswaramoorthy Source Type: research
< em > CYP2C19*17 < /em > association with higher plasma 4-hydroxy tamoxifen in Pakistani (estrogen-positive) breast cancer patients
This study was conducted to explore the influence of genetic polymorphisms in CYP2C19 gene on Tam's pharmacogenetics and pharmacokinetics in estrogen-positive BC patients. Data from healthy, unrelated individuals (n = 410; control group) and ER-positive BC patients (n = 430) receiving 20 mg of Tam per day were recruited. Steady-state plasma concentrations of Tam and its three metabolites were quantified using the high-performance liquid chromatography in the patients. The CYP2C19 polymorphisms were genotyped using an Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR) approach. More than 65% of he...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Muhammad Usman Tareen Sana Riaz Saima Shakil Malik Sana Zahid Anum Khursheed Fizza Tariq Faiza Abbas Muhammad Nouman Malik Riffat Aysha Anis Mariam Anees Iram Murtaza Aneesa Sultan Source Type: research
Circulating miR-221/222 expression as microRNA biomarker predicting tamoxifen treatment outcome: a case-control study
CONCLUSION: The use of circulating miR-221/222 expression can predict relapse as well as resistance to tamoxifen treatment in BC patients, and their testing is recommended for luminal subtype BC patients who will undergo tamoxifen therapy to determine their risk of tamoxifen resistance early, increasing treatment effectiveness.PMID:37554919 | PMC:PMC10406100 | DOI:10.1097/MS9.0000000000001061
Source: Cancer Control - August 9, 2023 Category: Cancer & Oncology Authors: Ilhamjaya Patellongi Alfiah Amiruddin Muhammad N Massi Andi A Islam Muhammad Y Pratama Noorwati Sutandyo Nani H M Latar Muhammad Faruk Source Type: research
Triple combination of palliative oral metronomic chemotherapy in recurrent and metastatic epithelial ovarian cancer: A retrospective study
CONCLUSION: Oral MCT was found to be an effective and well-tolerated regime with good symptomatic control and low-moderate toxicity profile in patients with relapsed and metastatic ovarian cancer. However, 22% of patients showed grade-III/IV thrombocytopenia.PMID:37530237 | DOI:10.4103/ijc.IJC_143_20
Source: Cancer Control - August 2, 2023 Category: Cancer & Oncology Authors: Kamlesh K Harsh Shankar L Jakhar Guncha Maheshwari Rajkumar Nirban Pramila Kumari Surender K Beniwal Neeti Sharma Harvindra S Kumar Source Type: research
HORMONET: a phase II trial of tamoxifen for estrogen/progesterone receptor-positive neuroendocrine tumors
CONCLUSION: Tamoxifen for ER-/PR-positive NETs patients is safe but offers modest antitumor effects.TRIAL REGISTRY NAME: Study of Tamoxifen in Well Differentiated Neuroendocrine Tumors and Hormone Receptor Positive Expression (HORMONET).URL: https://clinicaltrials.gov/ct2/show/NCT03870399?term=03870399&draw=2&rank=1.REGISTRATION NUMBER: NCT03870399.PMID:37529158 | PMC:PMC10387775 | DOI:10.1177/17588359231186041
Source: Cancer Control - August 2, 2023 Category: Cancer & Oncology Authors: Milton J Barros Jonathan Strosberg Taymeyah Al-Toubah Victor Hugo F de Jesus Lais Durant Celso A Mello Tiago C Felismino Louise De Brot Rodrigo G Taboada Mauro D Donadio Rachel P Riechelmann Source Type: research
Potential risk of tamoxifen: gut microbiota and inflammation in mice with breast cancer
CONCLUSION: Tamoxifen treatment significantly altered gut microbiota and increased inflammation in the breast cancer xenograft mice model. This may be related to tamoxifen-induced intestinal epithelial barrier damage and TLR5 up-regulation.PMID:37469407 | PMC:PMC10353877 | DOI:10.3389/fonc.2023.1121471
Source: Cancer Control - July 20, 2023 Category: Cancer & Oncology Authors: Hailong Li Xiufei Gao Yian Chen Mengqian Wang Chuchu Xu Qinghong Yu Ying Jin Jiaqing Song Qi Zhu Source Type: research
Comparative anticancer effects of Annona muricata Linn (Annonaceae) leaves and fruits on DMBA-induced breast cancer in female rats
CONCLUSION: These results confirm the anti-breast cancer effect of A. muricata, however, the aqueous fruit extract was more potent than the ethanolic leaves extract.PMID:37454062 | DOI:10.1186/s12906-023-04073-x
Source: Cancer Control - July 15, 2023 Category: Cancer & Oncology Authors: Kevine Kamga Silihe William Defo Mbou Judith Christiane Ngo Pambe Larissa Vanelle Kenmogne Laure Fotso Maptouom Marius Tr ésor Kemegne Sipping St éphane Zingue Dieudonn é Njamen Source Type: research
Combination of tamoxifen and D-limonene enhances therapeutic efficacy in breast cancer cells
Med Oncol. 2023 Jun 30;40(8):216. doi: 10.1007/s12032-023-02081-y.ABSTRACTBreast cancer one of the most common diseases in women, has a high death and morbidity rate. Tamoxifen being very much effective in the chemoprevention of breast cancer has been shown to develop resistance during the course of treatment making it difficult for patient's survival. By combining tamoxifen with naturally occurring substances having similar activities, might control the toxicity and increase the susceptibility towards the treatment. As a natural compound, D-limonene has been reported to inhibit the growth of certain malignancies significa...
Source: Cancer Control - June 30, 2023 Category: Cancer & Oncology Authors: Deepa Mandal Bikash Ranjan Sahu Tithi Parija Source Type: research
Spatiotemporal control of genome engineering in cone photoreceptors
CONCLUSIONS: The Arr3P2ACreERT2 mouse, an inducible cone-specific Cre driver, is a valuable line in studying cone cell biology, function, as well as its relationship with rod and other retinal cells. Moreover, the Cre activity can be induced by delivering tamoxifen intragastrically as early as PD2, which will be useful for studying retinal development or in rapid degenerative mouse models.PMID:37381060 | DOI:10.1186/s13578-023-01033-3
Source: Cancer Control - June 28, 2023 Category: Cancer & Oncology Authors: Nan-Kai Wang Pei-Kang Liu Yang Kong Yun-Ju Tseng Laura A Jenny Nicholas D Nolan Nelson Chen Hung-Hsi Wang Chun Wei Hsu Wan-Chun Huang Janet R Sparrow Chyuan-Sheng Lin Stephen H Tsang Source Type: research
Protective Effects of Pelargonidin against DMBA-Induced Mammary Tumorigenesis in BALB/c Mice through Reduced Oxidative Stress and Lipid Anomalies
Nutr Cancer. 2023 May 31:1-21. doi: 10.1080/01635581.2023.2219027. Online ahead of print.ABSTRACTAmong luminal types of breast cancers, ER + breast cancer is the most frequently diagnosed cancer globally. ER + breast cancer is commonly treated with SERM drugs that block ER to prevent ER-mediated cancerous growth. Our previous computational screening found pelargonidin (PG) can inhibit ER-signaling with potent bioactivity and satisfactory toxicological features. The present study explored the anti-tumoral prospect of PG against DMBA-induced ER + murine mammary carcinogenesis. The female BALB/c mice were divided into control...
Source: Cancer Control - May 31, 2023 Category: Cancer & Oncology Authors: Yahyea Baktiar Laskar Kasturi Bhattacharjee Moumita Nath Yashmin Choudhury Pranab Behari Mazumder Anupam Das Talukdar Source Type: research
An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean
In conclusion, although the global contribution of LAC countries remains low in the PGx field, a relevant improvement has been observed in the region. The perception of the usefulness of PGx tests in biomedical community has drastically changed, raising awareness among physicians, which suggests a promising future in the clinical applications of PGx in LAC.PMID:37251329 | PMC:PMC10213898 | DOI:10.3389/fphar.2023.1175737
Source: Cancer Control - May 30, 2023 Category: Cancer & Oncology Authors: Aime é Salas-Hernández Macarena Galleguillos Mat ías Carrasco Andr és López-Cortés Mar ía Ana Redal Dora Fonseca-Mendoza Patricia Esper ón Farith Gonz ález-Martínez Ismael Lares-Asseff Alberto Lazarowski Ver ónica Loera-Castañeda Diadelis Rem Source Type: research
The Incident Ocular Diseases Related to Chemotherapy in Cancer Patients are Associated with Increasing Risk of Incident Stroke
CONCLUSIONS: Incident ocular diseases related to chemotherapy were associated with a significantly higher risk of stroke.PMID:37229341 | PMC:PMC10203719 | DOI:10.6515/ACS.202305_39(3).20221005A
Source: Cancer Control - May 25, 2023 Category: Cancer & Oncology Authors: Kai-Chun Cheng Hung-Pin Tu Tsung-Hsien Lin Kai-Hung Cheng Source Type: research
Celastrol enhances tamoxifen sensitivity in the treatment of triple negative breast cancer via mitochondria mediated apoptosis pathway
CONCLUSION: CEL can promote apoptosis and enhance the TAM sensitivity in TNBC treatment through a mitochondria-mediated pathway.PMID:37193187 | PMC:PMC10182490
Source: Cancer Control - May 16, 2023 Category: Cancer & Oncology Authors: Bingjie Qi Qigao Yan Pei Zhang Yu Ren Huijuan Liu Tingting Liu Lingli Zhu Yu Chen Source Type: research
< em > Nrl:CreERT2 < /em > mouse model to induce mosaic gene expression in rod photoreceptors
Front Mol Neurosci. 2023 Apr 25;16:1161127. doi: 10.3389/fnmol.2023.1161127. eCollection 2023.ABSTRACTPhotoreceptors are sensory neurons that capture light within their outer segment, a narrow cylindrical organelle stacked with disc-shaped membranes housing the visual pigment. Photoreceptors are the most abundant neurons in the retina and are tightly packed to maximize the capture of incoming light. As a result, it is challenging to visualize an individual cell within a crowded photoreceptor population. To address this limitation, we developed a rod-specific mouse model that expresses tamoxifen-inducible cre recombinase un...
Source: Cancer Control - May 14, 2023 Category: Cancer & Oncology Authors: Molly T Thorson Stephanie E Wei Craig Johnson Christopher J Gabriel Vadim Y Arshavsky Jillian N Pearring Source Type: research
