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Total 130 results found since Jan 2013.
Favipiravir and Ribavirin protect immunocompetent mice from lethal CCHFV infection
In this study, we describe a lethal model of CCHFV infection using a mouse-adapted strain of CCHFV (MA-CCHFV) in adult wild-type male mice. Infected mice developed high viral loads, tissue pathology, inflammatory immune responses before ultimately succumbing to the infection. We used the model to evaluate the protective efficacy of nucleoside analogs monulpiravir, favipiravir, ribavirin, the antibiotic tigecycline and the corticosteroids dexamethasone and methylprednisolone against lethal CCHFV infection. Tigecycline, monulpiravir and the corticosteroids failed to protect mice from lethal MA-CCHFV infection. In contrast, f...
Source: Antiviral Research - August 23, 2023 Category: Virology Authors: Thomas Tipih Kimberly Meade-White Deepashri Rao Trenton Bushmaker Mathew Lewis Carl Shaia Heinz Feldmann David W Hawman Source Type: research
Improving COVID-19 Disease Severity Surveillance Measures: Statewide Implementation Experience
Ann Intern Med. 2023 May 16. doi: 10.7326/M23-0618. Online ahead of print.ABSTRACTMeasurement of the burden of COVID-19 on U.S. hospitals has been an important element of the public health response to the pandemic. However, because of variation in testing density and policies, the metric is not standardized across facilities. Two types of burdens exist, one related to the infection control measures that patients who test positive for SARS-CoV-2 require and one from the care of severely ill patients receiving treatment of COVID-19. With rising population immunity from vaccination and infection, as well as the availability o...
Source: Annals of Internal Medicine - May 15, 2023 Category: Internal Medicine Authors: Shira Doron Paul A Monach Catherine M Brown Westyn Branch-Elliman Source Type: research
Pharmacovigilance follow-up of patients in the context of the COVID-19 pandemic
DISCUSSION: This survey, based on real-time pharmacological and medical assessment of ADRs and weekly meetings in a specific national committee, made it possible to identify relevant safety signals which contribute to patient care with no delay. The main safety signal highlighted was serious cardiac damage under hydroxychloroquine, alone or combined with azithromycin and also with lopinavir/ritonavir. This signal has contributed to the evolution of the recommendations for these 2 drugs. The methodology of this survey has been taken over and is still going on for the pharmacovigilance monitoring of vaccines against COVID-19...
Source: Therapie - February 8, 2023 Category: Psychiatry & Psychology Authors: Aur élie Grandvuillemin Fanny Rocher Marie Blanche Valnet-Rabier Milou-Daniel Drici Anne Dautriche French Pharmacovigilance Network Source Type: research
Possibility of averting cytokine storm in SARS-COV 2 patients using specialized pro-resolving lipid mediators
Biochem Pharmacol. 2023 Jan 30:115437. doi: 10.1016/j.bcp.2023.115437. Online ahead of print.ABSTRACTFatal "cytokine storms (CS)" observed in critically ill COVID-19 patients are consequences of dysregulated host immune system and over-exuberant inflammatory response. Acute respiratory distress syndrome (ARDS), multi-system organ failure, and eventual death are distinctive symptoms, attributed to higher morbidity and mortality rates among these patients. Consequent efforts to save critical COVID-19 patients via the usage of several novel therapeutic options are put in force. Strategically, drugs being used in such patients...
Source: Biochemical Pharmacology - February 2, 2023 Category: Drugs & Pharmacology Authors: Nusrath Yasmeen S Harikrishnan Sudarshan S Lakhawat Manali Datta Pushpender K Sharma Ajay Jain Rakhi Khanna S Jayalakshmi Vikram Kumar Source Type: research
TWiV 978: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe dis...
Source: This Week in Virology - MP3 Edition - January 28, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
The effectiveness of dexamethasone as a combination therapy for COVID-19
Acta Pharm. 2022 Apr 13;72(3):345-358. doi: 10.2478/acph-2022-0030. Print 2022 Sep 1.ABSTRACTCoronavirus disease 2019 (COVID-19) was reported as a global pandemic in March 2020 after invading many countries and leaving behind tens of thousands of infected patients in a brief time span. Approval of a few vaccines has been obtained and their efficacy of varying degrees established. Still, there is no effective pharmaceutical agent for the treatment of COVID-19 though several drugs are undergoing clinical trials. Recent studies have shown that dexamethasone, a corticosteroid, can reduce the rate of COVID-19-related mortality ...
Source: Acta Pharmaceutica - January 18, 2023 Category: Drugs & Pharmacology Authors: Nader Namazi Source Type: research
