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Fertility-sparing hormonal treatment in patients with stage I endometrial cancer of grade 2 without myometrial invasion and grade 1-2 with superficial myometrial invasion: Gynecologic Oncology Research Investigators coLLaborAtion study (GORILLA-2001)
CONCLUSION: The overall response rate to FST was promising, however, the PD rate was significant during the first 12 months of FST. Therefore, performing thorough endometrial biopsy and imaging studies is essential to strictly evaluate the extent of the disease every 3 months from FST initiation.PMID:37172410 | DOI:10.1016/j.ygyno.2023.04.027
Source: Gynecologic Oncology - May 12, 2023 Category: Cancer & Oncology Authors: A Jin Lee Eun Jung Yang Nam Kyeong Kim Yeorae Kim Dong Hoon Suh Jeeyeon Kim Joo-Hyuk Son Tae-Wook Kong Suk-Joon Chang Dong Won Hwang Soo Jin Park Hee Seung Kim Ji Geun Yoo Sung Jong Lee Yoo-Young Lee Seung-Hyuk Shim Source Type: research

Characterization of GAB1 expression over the menstrual cycle in women with and without Polycystic Ovarian Syndrome provides a new insight into its pathophysiology.
Conclusions: GAB1 mRNA expression is positively modulated by E2. Endometrial GAB1 protein and mRNA expression are reduced in women with PCOS, suggesting that the endometrium of PCOS women have a defect in insulin signaling due to GAB1 down-regulation. PMID: 25144631 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - August 21, 2014 Category: Endocrinology Authors: Roemer KL, Young SL, Savaris RF Tags: J Clin Endocrinol Metab Source Type: research