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Specialty: Cancer & Oncology
Drug: Polyethylene Glycol
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Total 78 results found since Jan 2013.
Smart design of universally decorated nanoparticles for drug delivery applications driven by active transport
Eur Phys J E Soft Matter. 2023 Aug 31;46(9):74. doi: 10.1140/epje/s10189-023-00331-5.ABSTRACTTargeting the cell nucleus remains a challenge for drug delivery. Here, we present a universal platform for the smart design of nanoparticle (NP) decoration that is based on: (i) a spacer polymer, commonly biotin-polyethylene-glycol-thiol, whose grafting density and molecular weight can be tuned for optimized performance, and (ii) protein binding peptides, such as cell penetrating peptides (CPPs), cancer-targeting peptides, or nuclear localization signal (NLS) peptides, that are linked to the PEG free-end by universal chemistry. We...
Source: Cancer Control - August 31, 2023 Category: Cancer & Oncology Authors: Gal Halbi Itay Fayer Dina Aranovich Shachar Gat Mariela J Pavan Dikla Nachmias Daniel Sevilla Sanchez Ashraf Brik Rony Granek Anne Bernheim-Groswasser Source Type: research
Anaphylactic shock induced by polyethylene glycol after bowel preparation for the colorectal cancer surgery: A case report
CONCLUSION: While allergic reactions to PEG are rare, they can be life-threatening. Therefore, it is crucial for clinicians to be aware of this possibility and to diagnose and resuscitate patients immediately.PMID:37637691 | PMC:PMC10450373 | DOI:10.12998/wjcc.v11.i23.5589
Source: Clinical Colorectal Cancer - August 28, 2023 Category: Cancer & Oncology Authors: Go Woon Park Nahyeon Park Jung Cheol Kuk Eung Jin Shin Dae Ro Lim Source Type: research
Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy
Pharmaceutics. 2023 Aug 1;15(8):2068. doi: 10.3390/pharmaceutics15082068.ABSTRACTLipid nanoparticles (LNPs) have gained great attention as carriers for mRNA-based therapeutics, finding applications in various indications, extending beyond their recent use in vaccines for infectious diseases. However, many aspects of LNP structure and their effects on efficacy are not well characterized. To further exploit the potential of mRNA therapeutics, better control of the relationship between LNP formulation composition with internal structure and transfection efficiency in vitro is necessary. We compared two well-established ioniza...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Christoph Wilhelmy Isabell Sofia Keil Lukas Uebbing Martin A Schroer Daniel Franke Thomas Nawroth Matthias Barz Ugur Sahin Heinrich Haas Mustafa Diken Peter Langguth Source Type: research
Boron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment
Nanomaterials (Basel). 2023 Jul 26;13(15):2167. doi: 10.3390/nano13152167.ABSTRACTProton therapy is one of the promising radiotherapy modalities for the treatment of deep-seated and unresectable tumors, and its efficiency can further be enhanced by using boron-containing substances. Here, we explore the use of elemental boron (B) nanoparticles (NPs) as sensitizers for proton therapy enhancement. Prepared by methods of pulsed laser ablation in water, the used B NPs had a mean size of 50 nm, while a subsequent functionalization of the NPs by polyethylene glycol improved their colloidal stability in buffers. Laser-synthesized...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Irina N Zavestovskaya Anton L Popov Danil D Kolmanovich Gleb V Tikhonowski Andrei I Pastukhov Maxim S Savinov Pavel V Shakhov Julia S Babkova Anton A Popov Ivan V Zelepukin Maria S Grigoryeva Alexander E Shemyakov Sergey M Klimentov Vladimir A Ryabov Para Source Type: research
Application of thermoresponsive smart polymers based in situ gel as a novel carrier for tumor targeting
Curr Cancer Drug Targets. 2023 Aug 3. doi: 10.2174/1568009623666230803111718. Online ahead of print.ABSTRACTThe temperature-triggered in situ gelling system has been revolutionized by introducing an intelligent polymeric system. Temperature-triggered polymer solutions are initially in a sol state and then undergo a phase transition to form a gel at body temperature due to various parameters like pH, temperature, and so on. These smart polymers offer a number of advantages, including ease of administration, long duration of release of the drug, low administration frequency with good patient compliance, and targeted drug del...
Source: Current Cancer Drug Targets - August 3, 2023 Category: Cancer & Oncology Authors: Nidhi Sudhir Dhote Rajat Dineshbhai Patel Utkarsha Kuwar Mukta Agrawal Amit Alexander Parag Jain None Ajazuddin Source Type: research
A novel intra-tumoral drug delivery carrier for treatment of oral squamous cell carcinoma
This study evaluated a new intra-tumor-targeted drug delivery method for the treatment of OSCC induced on the dorsum of the tongue in white mice. The induced tumors were examined by needle biopsy. A targeted anticancer drug (Cetuximab) and [Cisplatin and 5 Fluorouracil (5-FU)] chemotherapeutic agents were loaded on polyethylene glycol-polylactide-polyethylene glycol (PEG-PLA-PEG) nanoparticles (NPs) designed for intralesional injection while systemic administration was used as control. Fourier transform infrared spectroscopy (FTIR) was performed to study NP chemical structure, a drug release profile was conducted to study ...
Source: Cancer Control - July 26, 2023 Category: Cancer & Oncology Authors: Shimaa A Elsaady Moustafa N Aboushelib Essam Al-Wakeel Manal F Badawi Source Type: research
A Case of Pseudoelevation of Prostate Specific Antigen Level
CONCLUSIONS: When the patient's PSA level is abnormally elevated, which is not consistent with the clinical diagnosis, we should consider immunological interference in PSA assays. Pretreatment with PEG may be an economical, simple, and feasible scheme for removing interference.PMID:37436390 | DOI:10.7754/Clin.Lab.2023.230107
Source: Clinical Prostate Cancer - July 12, 2023 Category: Cancer & Oncology Authors: Gangfeng Li Hongkun Xu Lihong Zhang Source Type: research
Polyethylene glycol and chitosan functionalized manganese oxide nanoparticles for antimicrobial and anticancer activities
J Colloid Interface Sci. 2023 Jun 9;648:907-915. doi: 10.1016/j.jcis.2023.06.029. Online ahead of print.ABSTRACTBiocompatible polymer-functionalized magnetic nanoparticles could offer promising applications in biomedical sciences. We fabricated polymer functionalized tri-manganese tetra oxide (Mn3O4) nanoparticles with the co-precipitation method and an octahedral crystal structure having a crystallite size of 10-17 nm was identified via XRD analyses. The SEM graph depicted the non-uniform and smooth surface of PEG-functionalized Mn3O4 NPs as compared to Mn3O4 and chitosan-coated Mn3O4 NPs. Elemental composition in the pre...
Source: Cancer Control - June 17, 2023 Category: Cancer & Oncology Authors: Arslan Mahmood Tariq Munir Azhar Rasul Ayman A Ghfar Sohail Mumtaz Source Type: research
An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells
In conclusion, ROS-mediated cell cycle arrest can be induced by PN as well as PNG nano-therapy in cell lines of colorectal cancer.PMID:37067762 | DOI:10.1007/s12013-023-01132-5
Source: Cancer Control - April 17, 2023 Category: Cancer & Oncology Authors: Ahmed A Abd-Rabou Aziza B Shalby Soheir E Kotob Source Type: research
Poly Ethylene Glycol (PEG)-based Hydrogels for Drug Delivery in Cancer Therapy
This article is protected by copyright. All rights reserved.PMID:37052256 | DOI:10.1002/adhm.202300105
Source: Cancer Control - April 13, 2023 Category: Cancer & Oncology Authors: Zihan Wang Qinzhou Ye Sheng Yu Behnam Akhavan Source Type: research
Targeted paclitaxel prodrug nanoassemblies to improve therapeutic effects for liver cancer
Colloids Surf B Biointerfaces. 2023 Mar 30;226:113285. doi: 10.1016/j.colsurfb.2023.113285. Online ahead of print.ABSTRACTProdrug nanoassemblies fabricated by anticancer drug conjugates exhibited more advantages in controlled drug release and bioavailability and favorable antitumor efficacy. In this paper, lactobionic acid (LA) was connected with polyethylene glycol through amido linkages, and paclitaxel was joined with polyethylene glycol by means of ester bonds to form the prodrug copolymer LA-PEG-PTX. Then, LA-PEG-PTX was automatically assembled into LA-PEG-PTX nanoparticles (LPP NPs) by dialysis. The LPP NPs had a rela...
Source: Cancer Control - April 7, 2023 Category: Cancer & Oncology Authors: Shasha Qin Jiamin Li Zhiling Pan Can Wang Bing-Feng Zhang Source Type: research
Polyethyleneimine/polyethylene glycol-conjugated gold nanoparticles as nanoscale positive/negative controls in nanotoxicology: testing in frog embryo teratogenesis assay- < em > Xenopus < /em > and mammalian tissue culture system
Nanotoxicology. 2023 Mar 15:1-22. doi: 10.1080/17435390.2023.2187322. Online ahead of print.ABSTRACTDespite the great potential of using positively charged gold nanoparticles (AuNPs) in nanomedicine, no systematic studies have been reported on their synthesis optimization or colloidal stability under physiological conditions until a group at the National Institute of Standards and Technology recently succeeded in producing remarkably stable polyethyleneimine (PEI)-coated AuNPs (Au-PEI). This improved version of Au-PEI (Au-PEI25kB) has increased the demand for toxicity and teratogenicity information for applications in nano...
Source: Cancer Control - March 15, 2023 Category: Cancer & Oncology Authors: Yoo-Seok Hwang Daeho So Moonsup Lee Jaeho Yoon Vytas Reipa Alessandro Tona Feng Yi Bryant C Nelson David A LaVan Vincent A Hackley Ira O Daar Tae Joon Cho Source Type: research
