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Drug: Aspirin

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A Retrospective Look at Patient, Procedural, and Follow-up Characteristics Associated With WATCHMAN Implantation
This study used a retrospective design to review data previously collected and entered into the National Cardiovascular Data Registry database.RESULTS: During a 2-year period, 41 patients underwent the WATCHMAN procedure at our facility. The most common indication for the procedure in this population of patients with nonvalvular AF on oral anticoagulants was bleeding in the gastrointestinal or genitourinary systems. (Gastrointestinal/genitourinary bleed does not limit candidacy for surgical closure of the LAA.) There was only 1 postprocedure adverse event that included a groin hematoma. A transesophageal echocardiogram at ...
Source: Dimensions in Critical Care Nursing - October 4, 2021 Category: Nursing Authors: Susan B Fowler Mary Janette Sendin Source Type: research

Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study
Conclusions A substantial proportion of the UK population carry genetic variants that reduce metabolism of clopidogrel to its active form. In family practice patients on clopidogrel, CYP2C19 LoF variants are associated with substantially higher incidence of ischaemic events. Genotype-guided selection of antiplatelet medications may improve outcomes in patients carrying CYP2C19 genetic variants.
Source: BMJ Open - December 13, 2021 Category: General Medicine Authors: Pilling, L. C., Türkmen, D., Fullalove, H., Atkins, J. L., Delgado, J., Kuo, C.-L., Kuchel, G. A., Ferrucci, L., Bowden, J., Masoli, J. A. H., Melzer, D. Tags: Open access, Cardiovascular medicine Source Type: research

Rapid detection of platelet inhibition and dysfunction in traumatic brain injury: A prospective observational study
CONCLUSION Rapid platelet function testing detects a highly prevalent poor platelet response among patients with tICH, irrespective of antiplatelet medication use. VerifyNow correlated fairly with whole blood aggregometry among patients with tICH and platelet responsiveness detectable by these tests did not correlate with clinical outcomes. In addition, our results suggest that platelet transfusion may not improve clinical outcomes in patients with tICH. LEVEL OF EVIDENCE Diagnostic tests, level II.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - December 28, 2021 Category: Orthopaedics Tags: ORIGINAL RESEARCH: INDEPENDENT SUBMISSIONS Source Type: research

Factors associated with stroke formation in blunt cerebrovascular injury: An EAST multicenter study
BACKGROUND Stroke risk factors after blunt cerebrovascular injury (BCVI) are ill-defined. We hypothesized that factors associated with stroke for BCVI would include medical therapy (i.e., Aspirin), radiographic features, and protocolization of care. METHODS An Eastern Association for the Surgery of Trauma–sponsored, 16-center, prospective, observational trial was undertaken. Stroke risk factors were analyzed individually for vertebral artery (VA) and internal carotid artery (ICA) BCVI. Blunt cerebrovascular injuries were graded on the standard 1 to 5 scale. Data were from the initial hospitalization only. R...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - February 1, 2022 Category: Orthopaedics Tags: 2021 EAST PODIUM PAPERS Source Type: research

Aspirin to Prevent Cancer: What to Tell Patients Aspirin to Prevent Cancer: What to Tell Patients
Dr Arefa Cassoobhoy highlights one of the week ' s most important news stories for primary care.Medscape Internal Medicine
Source: Medscape Internal Medicine Headlines - April 14, 2017 Category: Internal Medicine Tags: Internal Medicine Commentary Source Type: news

Antithrombotic strategies in the catheterization laboratory for patients with acute coronary syndromes undergoing percutaneous coronary interventions: insights from the EmploYEd antithrombotic therapies in patients with acute coronary Syndromes HOspitalized in iTalian cardiac care units Registry
Conclusion: In our contemporary, nationwide, all-comers cohort of ACS patients undergoing PCI, antithrombotic therapies were commonly initiated before the catheterization laboratory. In the periprocedural period, the most frequently employed drugs were unfractioned heparin, leading to a high rate of crossover, followed by GPIs and bivalirudin, mainly used during complex PCI. Clinical Trial Registration. URL: http://www.clinicaltrials.gov . Unique identifier: NCT02015624.
Source: Journal of Cardiovascular Medicine - June 30, 2017 Category: Cardiology Tags: Research articles Source Type: research

Bleeding and thrombotic complications of pediatric liver transplant
ConclusionsBoth bleeding and thrombosis are frequent in this population, but only thrombotic complications contributed to retransplantation and mortality. A standardized approach to coagulation testing and antithrombotic therapy may be useful in predicting and reducing adverse outcomes. Alternative approaches to monitoring hemostasis need to be prospectively investigated in this complex patient population.
Source: Pediatric Blood and Cancer - January 19, 2018 Category: Cancer & Oncology Authors: Alexandra J. Borst, Debra L. Sudan, Laura A. Wang, Michael J. Neuss, Jennifer A. Rothman, Thomas L. Ortel Tags: RESEARCH ARTICLE Source Type: research

Susac & #8217;s syndrome (retinocochleocerebral vasculopathy): Follow-up of a pediatric patient
Zeynep Selen Karalok, Birce Dilge Taskin, Alev Guven, Cemile Atilgan Ucgul, Omer Faruk AydinJournal of Pediatric Neurosciences 2017 12(4):374-377Susac’s syndrome (SS) is a triad of encephalopathy, branch retinal artery occlusion (BRAO), and sensorineural hearing loss as a result of microvascular occlusions of the brain, retina, and inner ear. It is also a disorder of autoimmune endotheliopathy. SS usually affects young women between the age of 20 and 40 years. SS can be misdiagnosed as multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM) because of similar findings. A 15-year-old girl present...
Source: Journal of Pediatric Neurosciences - March 26, 2018 Category: Neuroscience Authors: Zeynep Selen Karalok Birce Dilge Taskin Alev Guven Cemile Atilgan Ucgul Omer Faruk Aydin Source Type: research

Cardiovascular Disease and Risk Management: Review of the American Diabetes Association Standards of Medical Care in Diabetes 2018.
Abstract Description: The American Diabetes Association (ADA) annually updates its Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of patients with diabetes. Methods: For the 2018 standards, the ADA Professional Practice Committee searched MEDLINE through November 2017 to add, clarify, or revise recommendations on the basis of new evidence. The committee rated the recommendations as A, B, or C depending on the quality of evidence or E for expert consensus or clinical ex...
Source: Annals of Internal Medicine - April 3, 2018 Category: Internal Medicine Authors: Chamberlain JJ, Johnson EL, Leal S, Rhinehart AS, Shubrook JH, Peterson L Tags: Ann Intern Med Source Type: research

Quality of Cardiovascular Disease Care in Small Urban Practices.
CONCLUSION: Achieving targets for ABCS measures varied considerably across practices; however, small practices were meeting or exceeding Million Hearts goals (ie, 70% or greater). Practices were less likely to meet consistently clinical targets that apply to patients with a history of ASCVD risk factors. Greater emphasis is needed on providing support for small practices to address the complexity of managing patients with multiple risk factors for primary and secondary ASCVD. PMID: 29632222 [PubMed - in process]
Source: Annals of Family Medicine - April 1, 2018 Category: Primary Care Authors: Shelley D, Blechter B, Siman N, Jiang N, Cleland C, Ogedegbe G, Williams S, Wu W, Rogers E, Berry C Tags: Ann Fam Med Source Type: research

Low-dose aspirin and risk of upper/lower gastrointestinal bleeding by bleed severity: a cohort study with nested case-control analysis using primary care electronic health records from the United Kingdom.
CONCLUSION: Low-dose aspirin was associated with increased risks of non-fatal but not fatal UGIB/LGIB. Key message Low-dose aspirin is associated with an increased risks of non-fatal UGIB/LGIB but not fatal UGIB/LGIB. PMID: 31025592 [PubMed - as supplied by publisher]
Source: Annals of Medicine - April 28, 2019 Category: Internal Medicine Tags: Ann Med Source Type: research