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Source: Stroke
Drug: Aspirin

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Total 58 results found since Jan 2013.

Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients Clinical Sciences
Background and Purpose—In the SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), ticagrelor was not superior to aspirin. Because of differences in patient demographics and stroke disease pattern in Asia, outcomes of ticagrelor versus aspirin were assessed among Asian patients in a prespecified exploratory analysis.Methods—Baseline demographics, treatment effects, and safety of ticagrelor and aspirin were assessed among Asian patients. Differences in outcomes between groups were assessed using Cox proportional hazard model.Results—A total of 3858 (29.2%)...
Source: Stroke - December 22, 2016 Category: Neurology Authors: Yongjun Wang, Kazuo Minematsu, Ka Sing Lawrence Wong, Pierre Amarenco, Gregory W. Albers, Hans Denison, J. Donald Easton, Scott R. Evans, Peter Held, Jenny Jonasson, Carlos A. Molina, S. Claiborne Johnston Tags: Treatment, Cerebrovascular Disease/Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Letter by Moris and Avgerinos Regarding Article, “Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke: Clopidogrel Plus Aspirin Versus Aspirin Alone” Letter to the Editor
Source: Stroke - November 27, 2016 Category: Neurology Authors: Demetrios Moris, Efthymios Avgerinos Tags: Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research

Letter by Chen et al Regarding Article, “Left Ventricular Eȷection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data From the Warfarin Versus Aspirin in Reduced Eȷection Fraction Trial” Letter to the Editor
Source: Stroke - November 27, 2016 Category: Neurology Authors: Chen Chen, Dongze Li, Lixia Deng Tags: Arrhythmias, Heart Failure, Complications, Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research

Response by Di Tullio et al to Letter Regarding Article, “Left Ventricular Eȷection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data From the Warfarin Versus Aspirin in Reduced Eȷection Fraction Trial” Letter to the Editor
Source: Stroke - November 27, 2016 Category: Neurology Authors: Marco R. Di Tullio, John L.P. Thompson, Shunichi Homma, for the WARCEF Investigators Tags: Heart Failure, Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research

Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack Clinical Sciences
Background and Purpose—Patients with chronic kidney disease (CKD) are at a particularly high risk for ischemic and bleeding events. Limited data exist as to the efficacy and safety of clopidogrel in stroke patients with renal dysfunction. Therefore, we sought to assess the impact of decreased kidney function on clinical outcomes for stroke patients on clopidogrel–aspirin treatment.Methods—Patients in the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) were randomized to clopidogrel–aspirin or aspirin-alone treatment. The primary efficacy outcome was new stroke during ...
Source: Stroke - October 23, 2016 Category: Neurology Authors: Zhou, Y., Pan, Y., Wu, Y., Zhao, X., Li, H., Wang, D., Johnston, S. C., Liu, L., Wang, C., Meng, X., Wang, Y., , on behalf of the CHANCE Investigators Tags: Nephrology and Kidney, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke: Clopidogrel Plus Aspirin Versus Aspirin Alone Clinical Sciences
Conclusions— Clopidogrel plus aspirin might not be superior to aspirin alone for preventing new ischemic lesion and clinical vascular events in patients with acute ischemic stroke caused by large artery atherosclerosis. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00814268.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Hong, K.-S., Lee, S.-H., Kim, E. G., Cho, K.-H., Chang, D. I., Rha, J.-H., Bae, H.-J., Lee, K. B., Kim, D. E., Park, J.-M., Kim, H.-Y., Cha, J.-K., Yu, K.-H., Lee, Y.-S., Lee, S. J., Choi, J. C., Cho, Y.-J., Kwon, S. U., Kim, G.-M., Sohn, S.-I., Park, K.- Tags: Ischemic Stroke Clinical Sciences Source Type: research

Left Ventricular Ejection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data From the Warfarin Versus Aspirin in Reduced Ejection Fraction Trial Clinical Sciences
Conclusions— In patients with systolic HF and sinus rhythm, LVEF is inversely associated with death and its components, whereas an association with stroke exists for very low LVEF values. An interaction with warfarin treatment on stroke risk may exist. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00041938.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Di Tullio, M. R., Qian, M., Thompson, J. L. P., Labovitz, A. J., Mann, D. L., Sacco, R. L., Pullicino, P. M., Freudenberger, R. S., Teerlink, J. R., Graham, S., Lip, G. Y. H., Levin, B., Mohr, J. P., Buchsbaum, R., Estol, C. J., Lok, D. J., Ponikowski, P. Tags: Heart Failure, Echocardiography, Anticoagulants, Ischemic Stroke Clinical Sciences Source Type: research

PPM1A Methylation Is Associated With Vascular Recurrence in Aspirin-Treated Patients Brief Reports
Conclusions— The pattern of differential methylation in PPM1A is associated with vascular recurrence in aspirin-treated stroke patients.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Gallego-Fabrega, C., Carrera, C., Reny, J.-L., Fontana, P., Slowik, A., Pera, J., Pezzini, A., Serrano-Heras, G., Segura, T., Bin Dukhyil, A.-A. A., Marti-Fabregas, J., Muino, E., Cullell, N., Montaner, J., Krupinski, J., Fernandez-Cadenas, I. Tags: Ischemic Stroke Brief Reports Source Type: research

Aspirin for Stroke Prevention in Elderly Patients With Vascular Risk Factors: Japanese Primary Prevention Project Clinical Sciences
Conclusions— Aspirin did not show any net benefit for the primary prevention of stroke in elderly Japanese patients with risk factors for stroke, whereas age >70 years, smoking, and diabetes mellitus were risk factors for stroke regardless of aspirin treatment. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00225849.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Uchiyama, S., Ishizuka, N., Shimada, K., Teramoto, T., Yamazaki, T., Oikawa, S., Sugawara, M., Ando, K., Murata, M., Yokoyama, K., Minematsu, K., Matsumoto, M., Ikeda, Y., on behalf of the JPPP Study Group Tags: Cardiovascular Disease, Primary Prevention, Race and Ethnicity, Risk Factors Clinical Sciences Source Type: research

Time-Varying Effects of Prasugrel Versus Clopidogrel on the Long-Term Risks of Stroke After Acute Coronary Syndromes: Results From the TRILOGY ACS Trial Brief Reports
Conclusions— We observed a potential late treatment effect for prasugrel versus clopidogrel for a reduced risk of ischemic stroke in medically managed patients with ACS aged <75 years. These hypothesis-generating findings suggest that longer duration and more potent platelet inhibition with prasugrel may be associated with lower risk of ischemic stroke after 12 months. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00699998.
Source: Stroke - March 27, 2016 Category: Neurology Authors: Chin, C. T., Neely, B., Magnus Ohman, E., Armstrong, P. W., Corbalan, R., White, H. D., Prabhakaran, D., Winters, K. J., Fox, K. A. A., Roe, M. T., for the TRILOGY ACS Investigators Tags: Cerebrovascular Disease/Stroke, Acute Coronary Syndromes Brief Reports Source Type: research

Different Antiplatelet Strategies in Patients With New Ischemic Stroke While Taking Aspirin Clinical Sciences
Conclusions— This study showed that, compared with maintaining aspirin, switching to or adding alternative antiplatelet agents may be better in preventing subsequent vascular events in patients who experienced a new ischemic stroke while taking aspirin.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Kim, J.-T., Park, M.-S., Choi, K.-H., Cho, K.-H., Kim, B. J., Han, M.-K., Park, T. H., Park, S.-S., Lee, K. B., Lee, B.-C., Yu, K.-H., Oh, M. S., Cha, J. K., Kim, D.-H., Nah, H.-W., Lee, J., Lee, S. J., Ko, Y.-C., Kim, J. G., Park, J.-M., Kang, K., Cho, Y Tags: Secondary Prevention, Ischemic Stroke Clinical Sciences Source Type: research

Clinical and Economic Implications of Apixaban Versus Aspirin in the Low-Risk Nonvalvular Atrial Fibrillation Patients Clinical Sciences
Conclusions— Anticoagulant treatment with apixaban versus aspirin in low-risk patients, as identified using CHADS2 or CHA2DS2–VASc, is projected to increase life expectancy and provide clinical benefits that are cost effective.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Lip, G. Y. H., Lanitis, T., Mardekian, J., Kongnakorn, T., Phatak, H., Dorian, P. Tags: Primary prevention, Cerebrovascular disease/stroke, Anticoagulants, Antiplatelets Clinical Sciences Source Type: research

Clinical Implications of Changes in Individual Platelet Reactivity to Aspirin Over Time in Acute Ischemic Stroke Clinical Sciences
Conclusions— The results of our study showed that the increase in platelet reactivity to aspirin over time is independently associated with early neurological deterioration in patients with acute ischemic stroke. In addition, during the acute stage of ischemic stroke, serial platelet reactivity assays may be more useful than a single assay for identifying the clinical implications of aspirin platelet reactivity after ischemic stroke.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Kim, J.-T., Heo, S.-H., Choi, K.-H., Nam, T.-S., Choi, S.-M., Lee, S.-H., Park, M.-S., Kim, B. C., Kim, M.-K., Saver, J. L., Cho, K.-H. Tags: Secondary prevention, Cerebrovascular disease/stroke, Antiplatelets Clinical Sciences Source Type: research

Do Patient Characteristics Explain the Differences in Outcome Between Medically Treated Patients in SAMMPRIS and WASID? Clinical Sciences
Conclusions— After adjustment for confounding baseline characteristics, WASID patients had an almost 2-fold higher risk of the SAMMPRIS primary end point, which supports the hypothesis that the lower rate of the primary end point in the medical arm of SAMMPRIS compared with WASID patients was as a result of the aggressive medical management used in SAMMPRIS. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00576693.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Chaturvedi, S., Turan, T. N., Lynn, M. J., Derdeyn, C. P., Fiorella, D., Janis, L. S., Chimowitz, M. I., for the SAMMPRIS Trial Investigators Tags: Risk Factors Clinical Sciences Source Type: research

Premature Ventricular Complexes on Screening Electrocardiogram and Risk of Ischemic Stroke Brief Reports
Conclusions— PVCs are common on routine screening ECGs and are associated with an increased risk of ischemic stroke.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Agarwal, S. K., Chao, J., Peace, F., Judd, S. E., Kissela, B., Kleindorfer, D., Howard, V. J., Howard, G., Soliman, E. Z. Tags: Electrocardiology, Embolic stroke, Epidemiology Brief Reports Source Type: research