• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Opioid antagonists as potential therapeutics for ischemic stroke
Publication date: Available online 6 August 2019Source: Progress in NeurobiologyAuthor(s): Nadia Peyravian, Emre Dikici, Sapna Deo, Michal Toborek, Sylvia DaunertAbstractChronic use of prescription opioids can exacerbate risk and severity of ischemic stroke. Annually, 6 million people die from stroke worldwide and there are no neuroprotective or neurorestorative agents to improve stroke outcomes and promote recovery. Prescribed opioids such as morphine have been shown to alter tight junction protein expression, resulting in the disruption of the blood brain barrier (BBB), ultimately leading to stroke pathogenesis. Conseque...
Source: Progress in Neurobiology - August 7, 2019 Category: Neuroscience Source Type: research

S1-1. Spinal cord stimulation for post-stroke pain
Spinal cord stimulation (SCS) is used to treat for several types of intractable pain syndromes, but it is not commonly used for treating post-stroke pain. Therefore, in this study, we analyzed the effects of SCS in patients with post-stroke pain. Neurological imaging and pharmacological analysis using thiopental, ketamine and morphine tests were conducted for 30 patients with post-stroke pain. For all patients, percutaneous electrodes were inserted under local anesthesia, and trial stimulation was performed for 5–7days. If the patient experienced pain relief during the trial stimulation, a pulse generator was implanted. ...
Source: Clinical Neurophysiology - July 16, 2013 Category: Neuroscience Authors: Toshiki Obuchi, Mitsuru Watanabe, Koichiro Sumi, Toshikazu Kano, Kazutaka Kobayashi, Hideki Oshima, Chikashi Fukaya, Atsuo Yoshino, Takamitsu Yamamoto, Yoichi Katayama Tags: Society Proceedings Source Type: research

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases, including chronic neurodegenerative diseases, such as Alz...
Source: Molecular Brain - September 17, 2018 Category: Neuroscience Authors: Mar ía Rodríguez-Muñoz, Yara Onetti, Elsa Cortés-Montero, Javier Garzón and Pilar Sánchez-Blázquez Tags: Research Source Type: research