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Specialty: Cytology
Drug: Estradiol
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Total 158 results found since Jan 2013.
Biomonitoring of manganese metal pollution in water and its impacts on biological activities of Biomphalaria alexandrina snail and larvicidal potencies
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29786-x. Online ahead of print.ABSTRACTMetal pollution has many dangerous environmental and human health consequences due to the bioaccumulation in the tissues. The present study aims to measure the bioaccumulation factor of the manganese (Mn) heavy metal in Biomphalaria alexandrina snails' tissues and water samples. The current results showed the concentration of Mn heavy metal in water (87.5 mg/l) and its bioaccumulation factor in Helisoma duryi tissue was higher than that in tissues of Physa acuta and B. alexandrina snails. Results showed that 87.5 mg/l Mn...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Amina Mohamed Ibrahim Ahmed Abdel-Salam Abdel-Haleem Rania Gamal Taha Source Type: research
Decoding SEC24 Homolog D, COPII coat complex component accuracy as a signature gene in three human cancers
In this study, we conducted an extensive investigation of SEC24D, aiming to elucidate its potential role and underlying mechanisms across multiple human tumors. Our analysis relied on data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. To validate our findings, we employed RNA sequencing (RNA-seq), targeted bisulfite sequencing (bisulfite-seq) molecular techniques. Our findings revealed elevated mRNA (Messenger RNA) and protein levels of SEC24D in different tumor tissues. However, the up-regulation of SEC24D was significantly correlated with shorter overall survival (OS), metastasis, and v...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Weiwei Du Yang Sun Wentao Ji Tian Luo Dandan Zhang Weihong Guo Jianping Liang Yanhua Lv Mengwei Dong Kaixin Li Source Type: research
Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes
CONCLUSIONS: Plaque proteomics redefined clinically relevant patient groups with distinct outcomes, identifying subgroups of male and female patients with elevated risk of future cardiovascular events.PMID:37646165 | DOI:10.1161/CIRCRESAHA.123.322590
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Konstantinos Theofilatos Stefan Stojkovic Maria Hasman Sander W van der Laan Ferheen Baig Javier Barallobre-Barreiro Lukas Schmidt Siqi Yin Xiaoke Yin Sean Burnap Bhawana Singh Jude Popham Olesya Harkot Stephanie Kampf Maja Carina Nackenhorst Andreas Stra Source Type: research
FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer
CONCLUSIONS: Collectively, our data suggest that one mechanism by which obesity and weight gain promote breast cancer progression is through estrogen-independent ER activation and cancer cell metabolic reprogramming, partly driven by FGF/FGFR. The first-line treatment for many patients with ER-positive breast cancer is inhibition of estrogen synthesis using aromatase inhibitors. In women with obesity who are experiencing weight gain, locally produced FGF1 may activate ER to promote cancer cell metabolic reprogramming and tumor progression independently of estrogen.PMID:37608351 | DOI:10.1186/s13058-023-01699-0
Source: Cell Research - August 23, 2023 Category: Cytology Authors: Marisol Castillo-Castrejon Barbara Mensah Sankofi Stevi Johnson Murguia Abasi-Ama Udeme Hoaning Howard Cen Yi Han Xia Nisha S Thomas William L Berry Kenneth L Jones Vincent R Richard Rene P Zahedi Christoph H Borchers James D Johnson Elizabeth A Wellberg Source Type: research
Decrease in ER ɑ within the BNST of sexually naïve male rats following an encounter with a novel female
Behav Brain Res. 2023 Aug 16:114626. doi: 10.1016/j.bbr.2023.114626. Online ahead of print.ABSTRACTTestosterone and its metabolites facilitate male-typical social behaviors in sexually experienced animals. The metabolite estradiol acts on estrogen receptors (ERs) within the bed nucleus of the stria terminalis (BNST) to facilitate socio-sexual behaviors. While circulating testosterone does not increase in naïve males, aromatase-expressing neurons within the BNST of naïve males are necessary for sex recognition, suggesting that local estradiol production may be responsible. In the present study, we examined ERɑ-immunoreac...
Source: Cell Research - August 18, 2023 Category: Cytology Authors: Brianna M Bembenek Julia E Meyers-Manor Robin M Forbes-Lorman Source Type: research
Estradiol mitigates stress-induced cardiac injury and inflammation by downregulating ADAM17 via the GPER-1/PI3K signaling pathway
Cell Mol Life Sci. 2023 Aug 12;80(9):246. doi: 10.1007/s00018-023-04886-6.ABSTRACTStress-induced cardiovascular diseases characterized by inflammation are among the leading causes of morbidity and mortality in postmenopausal women worldwide. Estradiol (E2) is known to be cardioprotective via the modulation of inflammatory mediators during stress. But the mechanism is unclear. TNFα, a key player in inflammation, is primarily converted to its active form by 'A Disintegrin and Metalloprotease 17' (ADAM17). We investigated if E2 can regulate ADAM17 during stress. Experiments were performed using female FVB wild-type (WT), C57...
Source: Cellular and Molecular Life Sciences : CMLS - August 12, 2023 Category: Cytology Authors: Joseph Adu-Amankwaah Aisha Bushi Rubin Tan Adebayo Oluwafemi Adekunle Gabriel Komla Adzika Marie Louise Ndzie Noah Iqra Nadeem Seyram Yao Adzraku Stephane Koda Richard Mprah Jie Cui Kexue Li Prosperl Ivette Wowui Hong Sun Source Type: research
In vitro evaluation for estrogenic mechanisms of the disinfectant benzalkonium chloride as an emerging contaminant
This study aimed to evaluate in vitro the possible mechanisms underlying the estrogenic potential of benzalkonium chloride (BAC) as a disinfectant emerging contaminant. Effects of BAC at the environmentally-relevant concentrations on estrogen synthesis and estrogen receptor (ER) signaling were assessed using the H295R steroidogenesis assay and the MCF-7 proliferation assay, respectively. Results showed that exposure to BAC at concentrations of 1.0-1.5 mg/L for 48 h significantly increased estradiol production of H295R cells in a concentration-dependent manner. Transcription of steroidogenic genes 3β-HSD2, 17β-HSD1, 17β-...
Source: Cell Research - July 26, 2023 Category: Cytology Authors: Songyi Wei Xianmin Hu Xinyi Hu Yisheng Wan Guangquan Fan Jun Wang Source Type: research
Use of Mesenchymal Stem Cells in Experimental Ovarian Damage
CONCLUSION: The antioxidant and anti-apoptotic effects of MSCs could possibly explain the ability of this therapeutic modality to ameliorate BPA-induced-ovarian damage.PMID:37448361 | DOI:10.2174/1574888X18666230713121530
Source: Cell Research - July 14, 2023 Category: Cytology Authors: Hanan Fouad Ibrahim A Albahlol Hazim A Wahab Eman H Nadwa Heba M Galal Mohamed Abouelkheir Ahmed E Taha Abdelkarim G Kamel Hassan A Abdelmawlla Source Type: research
Protective effect of Salvia hispanica (chia seeds) against obesity induced ovarian disorders in rat model
Tissue Cell. 2023 Jul 5;83:102156. doi: 10.1016/j.tice.2023.102156. Online ahead of print.ABSTRACTThe main goal of the current report is to assess the protective impacts of chia seeds against obesity-induced ovarian dysfunctions with a trial to elucidate the mechanism of action. Forty rats were divided into 4 groups including lean untreated, lean consuming chia seeds, obese untreated, and rats consumed high-fat diet (HFD) mixed with ground chia seeds for 10 weeks. Anthropometric measures including visceral fat, peri-ovarian fat, ovarian weights, and duration of the estrous cycle were computed. Serum luteinizing (LH), folli...
Source: Tissue and Cell - July 12, 2023 Category: Cytology Authors: Eman Mahmoud FaragAllah Samah Attia Algharib Nehal I A Goda Nanees F El-Malkey Heba H Mahboub Shaimaa H El-Fayoumi Nawal Al-Hoshani Reham M Wahid Mohamed Aref Source Type: research
The effect of daidzein on renal injury in ovariectomized rats: interaction of angiotensin receptors and long non-coding RNAs H19, GAS5, MIAT, and Rian
CONCLUSION: Daidzein alone and in co-treatment with A779 and losartan improved renal injury in UUO rats and recovered dysregulated expression of UUO-related lncRNAs through modulating MasR and AT1R receptors, associating with modulation of the expression of lncRNAs. Daidzein could be considered a renoprotective phytoestrogen substitute for E2 therapy in postmenopausal women suffering from renal diseases.PMID:37378389 | PMC:PMC10291528 | DOI:10.22099/IJVR.2023.43460.6357
Source: Cell Research - June 28, 2023 Category: Cytology Authors: M Askaripour H Najafipour S Jafarinejad-Farsangi S Rajabi Sh Saberi E Jafari Source Type: research
HSD17B4 methylation enhances glucose dependence of BT-474 breast cancer cells and increases lapatinib sensitivity
CONCLUSION: HSD17B4 KO in BT-474 cells caused a decrease of PUFAs, increased Akt phosphorylation, enhanced glucose dependence of OxPhos, and increased sensitivity to inhibition of HER2, upstream of Akt. This mechanism may be applicable to other HER2-positive glucose-dependent breast cancer cells with HSD17B4 silencing.PMID:37378696 | DOI:10.1007/s10549-023-07013-y
Source: Cell Research - June 28, 2023 Category: Cytology Authors: Nobuaki Arai Naoko Hattori Satoshi Yamashita Yu-Yu Liu Takahiro Ebata Chihiro Takeuchi Hideyuki Takeshima Satoshi Fujii Haruhiko Kondo Hirofumi Mukai Toshikazu Ushijima Source Type: research
Autocrine 17- β-estradiol/estrogen receptor-α loop determines the response to immune-checkpoint inhibitors in non-small cell lung cancer
CONCLUSIONS: Our work unveils that 17-β-estradiol/ERα status predicts the response to pembrolizumab in NSCLC patients. Secondly, we propose aromatase inhibitors as new gender-tailored immune-adjuvants in NSCLC.PMID:37285115 | DOI:10.1158/1078-0432.CCR-22-3949
Source: Cell Research - June 7, 2023 Category: Cytology Authors: Dario P Anobile Iris C Salaroglio Fabrizio Tabb ò Sofia La Vecchia Muhlis Akman Francesca Napoli Maristella Bungaro Federica Benso Elisabetta Aldieri Paolo Bironzo Joanna Kopecka Francesco Passiglia Luisella Righi Silvia Novello Giorgio V Scagliotti Chia Source Type: research
