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Specialty: Cancer & Oncology
Drug: Metformin
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Total 283 results found since Jan 2013.
Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer
J Clin Oncol. 2023 Sep 11:JCO2300296. doi: 10.1200/JCO.23.00296. Online ahead of print.ABSTRACTClinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available. Clinical trial updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.Metformin has been associated with lower cancer risk in epidemiologic and preclinical research. In the MA.32 rando...
Source: Clinical Breast Cancer - September 11, 2023 Category: Cancer & Oncology Authors: Pamela J Goodwin Bingshu E Chen Karen A Gelmon Timothy J Whelan Marguerite Ennis Julie Lemieux Jennifer A Ligibel Dawn L Hershman Ingrid A Mayer Timothy J Hobday Judith M Bliss Priya Rastogi Manuela Rabaglio-Poretti Alastair M Thompson Daniel W Rea Paul M Source Type: research
Ultra-efficient radio-immunotherapy for reprogramming the hypoxic and immunosuppressive tumor microenvironment with durable innate immune memory
Biomaterials. 2023 Sep 5;302:122303. doi: 10.1016/j.biomaterials.2023.122303. Online ahead of print.ABSTRACTRadiosensitization efficacy of conventional tumor radiosensitizers has been frequently limited by insufficient competence for tumor microenvironment (TME) regulation and unfavorable cellular uptake at biological barriers. Here, we reported an ultra-efficient radiotherapy (RT) strategy by synthesizing an extracellular vesicles (EVs)-encapsulated hollow MnO2 to load metformin (Met@HMnER). It demonstrated significant RT enhancement by morphological control of catalyst and cellular respiratory depression against conventi...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Jichun Yang Chong Zhang Xiaohui Chen Daijun Zhou Zixin Sun Ruyan Niu Ying Zhu Hengyi Chen Liu Wang Yi Chen Yuhan Wang Yunqian Fu Ningyu Ma Jianjun Li Yang Luo Source Type: research
Metformin and Aspirin: Anticancer effects on A549 and PC3 cancer cells and the mechanisms of action
This study aims to investigate the effect of metformin and aspirin and their combination of them on A549 and PC3 cell lines. Metformin and aspirin were investigated separately and in combination on two cancer cell lines, A549 and PC3. The examined groups include the negative control of untreated cells and the positive control of cisplatin and drugs at concentrations of 15, 10, and 20 μg/ mL to investigate the mechanism of oxidative stress factors (reactive oxygen species, lipid peroxidation, Glutathione (GSH)) and apoptosis (lactate dehydrogenase). The results showed that aspirin, metformin, and their combination could af...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Farzaneh Motafeghi Romina Shahsavari Parham Mortazavi Aysan Babaei Pouria SamadiMojaveri Omid Abed Khojasteh Mohammad Shokrzadeh Source Type: research
Efficacy of metformin in prevention of paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled trial
Conclusion: The use of metformin in breast cancer patients offered a marked protection against paclitaxel-induced PN, which translated to better patient QoL. Clinical Trial Registration: https://classic.clinicaltrials.gov/ct2/show/NCT05351021, identifier NCT05351021.PMID:37583905 | PMC:PMC10424931 | DOI:10.3389/fphar.2023.1181312
Source: Cancer Control - August 16, 2023 Category: Cancer & Oncology Authors: Hala M Bakry Noha O Mansour Tawfik R ElKhodary Moetaza M Soliman Source Type: research
Injectable periodontal ligament stem cell-metformin-calcium phosphate scaffold for bone regeneration and vascularization in rats
CONCLUSIONS: The novel injectable construct with hPDLSC and Met encapsulation demonstrated excellent efficacy for bone regeneration and vascularization in vivo in an animal model. CPC+hPDLSCs+ 0.1%Met is highly promising for dental and craniofacial applications.PMID:37574338 | DOI:10.1016/j.dental.2023.07.008
Source: Cancer Control - August 13, 2023 Category: Cancer & Oncology Authors: Yaxi Sun Zeqing Zhao Qingchen Qiao Shengnan Li Wenting Yu Xiuchen Guan Abraham Schneider Michael D Weir Hockin H K Xu Ke Zhang Yuxing Bai Source Type: research
Hypoglycemic agents and incidence of pancreatic cancer in diabetic patients: a meta-analysis
Conclusion: Sulfonylureas and insulin may increase the incidence of pancreatic cancer in diabetic patients, with varying effects observed among different ethnicities (Asian and Western). Due to significant heterogeneity across studies, further interpretation of the relationship between hypoglycemic agents and pancreatic cancer incidence in diabetic patients requires well-adjusted data and better-organized clinical trials.PMID:37497113 | PMC:PMC10366383 | DOI:10.3389/fphar.2023.1193610
Source: Cancer Control - July 27, 2023 Category: Cancer & Oncology Authors: Zimo Zhao Xinyi He Yan Sun Source Type: research
Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma
CONCLUSION: Reducing insulin feedback improves the efficacy of PI3K inhibition in glioblastoma in mice, and hyperglycemia worsens progression-free survival in patients with glioblastoma treated with PI3K inhibition. These findings indicate that hyperglycemia is a critical resistance mechanism associated with PI3K inhibition in glioblastoma and that anti-hyperglycemic therapy may enhance PI3K inhibitor efficacy in glioblastoma patients.PMID:37399061 | DOI:10.1093/neuonc/noad117
Source: Cancer Control - July 3, 2023 Category: Cancer & Oncology Authors: Evan K Noch Laura N Palma Isaiah Yim Nayah Bullen Yuqing Qiu Hiranmayi Ravichandran Junbum Kim Andre Rendeiro Melissa B Davis Olivier Elemento David J Pisapia Kevin Zhai H Carl LeKaye Jason A Koutcher Patrick Y Wen Keith L Ligon Lewis C Cantley Source Type: research
Metformin is associated with improved clinical outcomes in patients with melanoma: a retrospective, multi-institutional study
CONCLUSION: This is the first study to demonstrate significantly improved clinical outcomes in diabetic melanoma patients exposed to metformin. Overall, these results provide further rationale for ongoing clinical trials studying the potential augmentation of checkpoint blockade with metformin in advanced melanoma.PMID:37397389 | PMC:PMC10312386 | DOI:10.3389/fonc.2023.1075823
Source: Ann Oncol - July 3, 2023 Category: Cancer & Oncology Authors: Ryan C Augustin Ziyu Huang Fei Ding Shuyan Zhai Jennifer McArdle Anthony Santisi Michael Davis Cindy Sander Diwakar Davar John M Kirkwood Greg M Delgoffe Allison Betof Warner Yana G Najjar Source Type: research
Oxidative brain and cerebellum injury in diabetes and prostate cancer model: Protective effect of metformin
J Biochem Mol Toxicol. 2023 Jun 24:e23440. doi: 10.1002/jbt.23440. Online ahead of print.ABSTRACTThe body can host the spread of prostate cancer cells. Metastases from prostate cancer are more frequently seen in the brain, liver, lungs, and lymph nodes. A well-known antidiabetic drug, metformin, is also known to have antitumor effects. Our study focuses on the evaluation of potential metformin protective effects on brain and cerebellum damage in streptozotocin (STZ)-induced diabetic and Dunning prostate cancer models. In this investigation, six groups of male Copenhagen rats were created: control, diabetic (D), cancer (C),...
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: Eda Dagsuyu P ınar Koroglu Ilknur B Gul Omur K Bulan Refiye Yanardag Source Type: research
Kr üppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors
CONCLUSIONS: These results demonstrated a novel signaling pathway by which KLF10 modulates stem cell phenotypes in PDAC through transcriptionally regulating Notch signaling pathway. The elevation of KLF10 and suppression of Notch signaling may jointly reduce PDAC tumorigenesis and malignant progression.PMID:37308977 | DOI:10.1186/s12929-023-00937-z
Source: Cancer Control - June 12, 2023 Category: Cancer & Oncology Authors: Yi-Chih Tsai Kung Hung Cheng Shih Sheng Jiang John R Hawse Shun En Chuang Su Liang Chen Tze-Sing Huang Hui-Ju Ch'ang Source Type: research
Investigation of glycaemic and nutritional status of patients suffering from cancer.
CONCLUSION: Based on our results, targeted screening for cancer among diabetic patients, and seeking and adequately treating glycometabolic disorders with concomitant malignant conditions, respectively , are suggested, mainly using metformin and new non-insulin antidiabetic medicines. Through these efforts, the fight against cancer can be more effective. Orv Hetil. 2023; 164(23) 900-910.PMID:37302126 | DOI:10.1556/650.2023.32796
Source: Cancer Control - June 11, 2023 Category: Cancer & Oncology Authors: R óbert János Bánhegyi Blanka Ver éb Ádám Attila Mátrai Beatrix R ácz Szilvia Beke Source Type: research
Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response
CONCLUSIONS: These findings identify regulated oncogene-driven macropinocytosis in thyroid cancers and demonstrate the potential of designing albumin-bound drugs to efficiently treat them.PMID:37289199 | DOI:10.1158/1078-0432.CCR-22-2976
Source: Clinical Cancer Research - June 8, 2023 Category: Cancer & Oncology Authors: Huiyu Hu Thomas S C Ng Mikyung Kang Ella Scott Ran Li Jeremy M Quintana Dylan Matvey Venkata R Vantaku Ralph Weissleder Sareh Parangi Miles A Miller Source Type: research
