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Drug: Metformin

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Total 9821 results found since Jan 2013.

Plasma Metformin Levels at Almost 24 Hours Would Help With the Delicate Decision to Start Renal Replacement Therapy: We Disagree as Lactate That Is More Widely and Early Available Should Be a Much Better Trigger to Start Renal Replacement Therapy!
No abstract available
Source: Critical Care Medicine - March 25, 2021 Category: Emergency Medicine Tags: Online Letters to The Editor Source Type: research

Metformin: An Intriguing Protective Agent in Hospitalized Diabetic Patients With Sepsis*
No abstract available
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Metformin Use and VTE Risk in Adults With Type 2 Diabetes Metformin Use and VTE Risk in Adults With Type 2 Diabetes
Might metformin use reduce the risk of venous thromboembolism in patients with type 2 diabetes mellitus?American Journal of Epidemiology
Source: Medscape Critical Care Headlines - June 14, 2022 Category: Intensive Care Tags: Internal Medicine Journal Article Source Type: news

Safety and Tolerability of the Treatment of Youth-Onset Type 2 Diabetes: The TODAY experience.
CONCLUSIONS The TODAY study represents extensive experience managing type 2 diabetes in youth and found that the three treatment approaches were generally safe and well tolerated. Adding rosiglitazone to metformin may reduce GI side effects and hepatotoxicity. PMID: 23704676 [PubMed - in process]
Source: Diabetes Care - May 29, 2013 Category: Endocrinology Authors: TODAY Study Group Tags: Diabetes Care Source Type: research

In vitro and in vivo investigation of PLA/PCL scaffold coated with metformin-loaded gelatin nanocarriers in regeneration of critical-sized bone defects
Publication date: Available online 28 June 2018 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Mostafa Shahrezaee, Majid Salehi, Sara Keshtkari, Ahmad Oryan, Amir Kamali, Babak Shekarchi Large bone defects constitute a major challenge in bone tissue engineering and usually fail to heal due to the incomplete differentiation of recruited mesenchymal stem cells (MSCs) into osteogenic precursor cells. As previously proposed, metformin (MET) induces differentiation of MSCs into osteoblastic lineages in vitro. We fabricated a Poly (lactic acid) and Polycaprolactone (PLA/PCL) scaffold to deliver metformin l...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 29, 2018 Category: Nanotechnology Source Type: research

Predictors for successful weight reduction during treatment with Dapagliflozin among patients with type 2 diabetes mellitus in primary care
CONCLUSIONS: T2DM patients that performed regular exercise, had normal renal function and were receiving metformin were more likely to have clinically meaningful body weight reduction after one year treatment with dapagliflozin.PMID:35624416 | PMC:PMC9137162 | DOI:10.1186/s12875-022-01748-1
Source: Primary Care - May 27, 2022 Category: Primary Care Authors: Youn Huh Young Sik Kim Source Type: research

A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation
ConclusionsThe MTD of VIT with metformin was not determined due to premature study closure. We recommend an RP2D of Dose Level 4, 1666  mg/m2/day. Radiographic responses were seen in multiple tumor types. Further evaluation for efficacy could be investigated in a Phase II trial.
Source: Cancer Medicine - September 24, 2022 Category: Cancer & Oncology Authors: Jonathan L. Metts, Matteo Trucco, Daniel A. Weiser, Patrick Thompson, Eric Sandler, Tiffany Smith, Jessica Crimella, Samer Sansil, Ram Thapa, Brooke L. Fridley, Nicholas Llosa, Thomas Badgett, Richard Gorlick, Damon Reed, Jonathan Gill Tags: RESEARCH ARTICLE Source Type: research

Biochemical profiling, pharmacological management and clinical outcomes in type 2 diabetes in Danish primary care from 2001 to 2015
CONCLUSION: The number of individuals with T2D in primary care increased dramatically whereas pharmacological management, control of risk factors and clinical outcomes seem to have improved. Nevertheless, a conspicuous minority did not receive diabetes-related medication.PMID:36272916 | DOI:10.1016/j.pcd.2022.10.006
Source: Primary Care - October 22, 2022 Category: Primary Care Authors: Niels S øndergaard Heinrich Margit Kriegbaum Mia Klinten Grand Bent Struer Lind Christen Lykkegaard Andersen Frederik Persson Source Type: research

Patient and provider prediabetes knowledge, attitudes, and behavior in a large urban family medicine practice
Conclusions: Providers and patients saw prediabetes as important but reported knowledge and management gaps, particularly for metformin and DPP, and requested additional practice resources.PMID:36857128 | DOI:10.1370/afm.20.s1.2748
Source: Annals of Family Medicine - March 1, 2023 Category: Primary Care Authors: Amy Cunningham Erica Li Alexis Silverio Geoffrey Mills Jasmine Han Alexa Waters Source Type: research

The correlation between vitamin B12 and folate levels and bone mineral density among the Saudi population in a primary care setting
CONCLUSION: Vitamin B12 is associated with fracture risk; however, vitamin B12 and folate levels are not correlated to BMD (femoral neck and lumbar spine).PMID:37636170 | PMC:PMC10451589 | DOI:10.4103/jfmpc.jfmpc_1209_22
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Sarah I Bin Hussain Abdullah AlKhenizan Ahmed Mahmoud Hussain Qashlaq Source Type: research