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Drug: Metformin
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Total 57 results found since Jan 2013.

Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial
CONCLUSION: Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness successfully recruited a diverse study population with relatively new onset of type 2 diabetes mellitus, relying to a large extent on the use of Electronic Health Record to screen potential participants. A comprehensive approach to recruitment with frequent monitoring was critical to meet the recruitment goal.PMID:37329282 | DOI:10.1177/17407745231175919
Source: Clinical Trials - June 17, 2023 Category: Research Authors: Andrea L Cherrington Heidi Krause-Steinrauf Vanita Aroda John B Buse Basma Fattaleh Stephen P Fortmann Stephanie Hall Sophia H Hox Alexander Kuhn Tina Killean Amy Loveland Lawrence S Phillips Analyn Uy Jackson Andrea Waltje M Diane McKee GRADE Research Gr Source Type: research

Academic detailing as a method to improve general practitioners' drug prescribing in type 2 diabetes: evaluation of changes in prescribing
CONCLUSION: Academic detailing initiated a small but statistically significant increase in the prescription of metformin. For a complex subject like type 2 diabetes, we recommend reserving more time in the visit than the 20 min our campaign aimed for.PMID:37326464 | DOI:10.1080/02813432.2023.2222781
Source: Primary Care - June 16, 2023 Category: Primary Care Authors: Harald Christian Langaas Øyvind Salvesen Roar Dyrkorn Hege Salvesen Blix Olav Spigset Source Type: research

Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Looking Back at the Growth and Maturation of the Field of Aging Research
A great deal has changed in these last few decades in the field of aging research. From the 60s onward to the 90s, aging research was increasingly characterized by a philosophy of "look but don't touch", an effort to distance academia from the growing anti-aging industry and its hype. It made itself a backwater science in which talk of intervention was aggressively discouraged by leaders in the field. Starting in the 90s, with studies showing significant life extension in lower animals following single gene mutations, it became impossible to ignore the potential to treat aging as a medical condition in humans. Nonet...
Source: Fight Aging! - June 9, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Patient and provider prediabetes knowledge, attitudes, and behavior in a large urban family medicine practice
Conclusions: Providers and patients saw prediabetes as important but reported knowledge and management gaps, particularly for metformin and DPP, and requested additional practice resources.PMID:36857128 | DOI:10.1370/afm.20.s1.2748
Source: Annals of Family Medicine - March 1, 2023 Category: Primary Care Authors: Amy Cunningham Erica Li Alexis Silverio Geoffrey Mills Jasmine Han Alexa Waters Source Type: research

Five-year weight loss maintenance with obesity pharmacotherapy
CONCLUSION: Clinically significant long-term weight loss of 10% or more beyond four years is achievable in clinical practice settings with obesity pharmacotherapy.PMID:36810608 | DOI:10.1210/clinem/dgad100
Source: The Journal of Clinical Endocrinology and Metabolism - February 22, 2023 Category: Endocrinology Authors: Michael A Weintraub Debra D'Angelo Beverly G Tchang Ageline D Sahagun Clarissa Andre Louis J Aronne Alpana P Shukla Source Type: research

Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review
Eur J Pharmacol. 2022 Sep 28:175299. doi: 10.1016/j.ejphar.2022.175299. Online ahead of print.ABSTRACTCataract is the leading cause of blindness worldwide. Cataract phacoemulsification combined with intraocular lens implantation causes great burden to global healthcare, especially for low- and middle-income countries. Such burden would be significantly relieved if cataracts can effectively be treated or delayed by non-surgical means. Excitingly, novel drugs have been developed to treat cataracts in recent decades. For example, oxysterols are found to be able to innovatively reverse lens clouding, novel nanotechnology-loade...
Source: European Journal of Pharmacology - October 1, 2022 Category: Drugs & Pharmacology Authors: Ao Lu Ping Duan Jing Xie Hui Gao Mengmeng Chen Yu Gong Jiawen Li Haiwei Xu Source Type: research

Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research