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Total 59 results found since Jan 2013.

Association between Glucose-Lowering Treatments and Risk of Diabetic Retinopathy in People with Type 2 Diabetes: A Nationwide Cohort Study
Conclusion Findings from this study indicate that basal insulin and GLP-1-RA are suboptimal second-line choices for people with type 2 diabetes at risk of developing diabetic retinopathy. However, many other considerations concerning the choice of second-line glucose-lowering treatment for type 2 diabetes patients should be taken into account.PMID:37078347 | DOI:10.2174/1574886318666230420084701
Source: Current Drug Safety - April 20, 2023 Category: Drugs & Pharmacology Authors: Jakob Hasselstr øm Jensen Peter Vestergaard Morten Hasselstr øm Jensen Source Type: research

Patient and provider prediabetes knowledge, attitudes, and behavior in a large urban family medicine practice
Conclusions: Providers and patients saw prediabetes as important but reported knowledge and management gaps, particularly for metformin and DPP, and requested additional practice resources.PMID:36857128 | DOI:10.1370/afm.20.s1.2748
Source: Annals of Family Medicine - March 1, 2023 Category: Primary Care Authors: Amy Cunningham Erica Li Alexis Silverio Geoffrey Mills Jasmine Han Alexa Waters Source Type: research

Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting. Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 22nd 2022
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period.
Source: Fight Aging! - August 21, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Bacteria-mediated metformin-loaded peptide hydrogel reprograms the tumor immune microenvironment in glioblastoma
Biomaterials. 2022 Aug 5:121711. doi: 10.1016/j.biomaterials.2022.121711. Online ahead of print.ABSTRACTThe tumor immune microenvironment (TIME) is one of the significant hallmarks of cancer and has the important role of largely determining the malignancy level of tumors. As an approach to break through this bottleneck of tumor treatment methods, the TIME can be reprogrammed by certain nanomaterials. Here, we coated C-novyi-spores with melittin-RADA32 nanofiber hybrid peptide and loaded the immunomodulator metformin to obtain MRM-coated spores as a powerful antitumor nanodrug against glioblastoma (GBM), which is based on t...
Source: Biomaterials - August 10, 2022 Category: Materials Science Authors: Lisheng Zhu Jingyu Liu Mengjun Qiu Jiayuan Chen Qing Liang Gang Peng Zhenwei Zou Source Type: research