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Drug: Warfarin
Therapy: Dialysis
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Total 50 results found since Jan 2013.
Nephrogenic Calciphylaxis Arising After Bariatric Surgery: A Case Series
We report a case series of five bariatric patients from a single institution who developed nephrogenic calciphylaxis between 2012-2018. These patients had a history of bariatric surgery and at the time of calciphylaxis diagnosis, demonstrated laboratory abnormalities associated with surgery including hypercalcemia (n=3), hyperparathyroidism (n=2), hypoalbuminemia (n=5), and vitamin D deficiency (n=5), in addition to other medication exposures such as vitamin D supplementation (n=2), calcium supplementation (n=4), warfarin (n=2), and intravenous iron (n=1). Despite the multifactorial etiology of calciphylaxis and the many r...
Source: American Journal of Nephrology - July 24, 2023 Category: Urology & Nephrology Authors: Joyce Xia Alice J Tan Bianca Biglione Bethany Cucka Lauren Ko Emily Nguyen Charbel C Khoury Malcolm Robinson Sagar U Nigwekar Daniela Kroshinsky Source Type: research
Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma
Biochem Biophys Res Commun. 2023 Feb 10;651:114-120. doi: 10.1016/j.bbrc.2023.02.021. Online ahead of print.ABSTRACTIn pharmacokinetics plasma protein binding (PPB) is a well-established parameter impacting drug disposition. The unbound fraction (fu) is arguably regarded the effective concentration at the target site. Pharmacology and toxicology, increasingly use in vitro models. The translation of in vitro concentrations to in vivo doses can be supported by toxicokinetic modelling, e.g. physiologically based toxicokinetic models (PBTK). PPB of a test substance is an input parameter for PBTK. We compared three methods to q...
Source: Biochemical and Biophysical Research communications - February 22, 2023 Category: Biochemistry Authors: Dunja Dimitrijevic Eric Fabian Dorothee Funk-Weyer Robert Landsiedel Source Type: research
Oral Anticoagulation Therapy in Atrial Fibrillation Patients with Advanced Chronic Kidney Disease: CODE-AF Registry
CONCLUSION: Among AF patients with advanced CKD or ESRD on dialysis, DOAC was associated with a lower risk of major or CRNM bleeding compared to warfarin and a lower risk of composite adverse clinical outcomes compared to no OAC. ClinicalTrials.gov (NCT02786095).PMID:36579375 | DOI:10.3349/ymj.2022.0455
Source: Yonsei Medical Journal - December 29, 2022 Category: Universities & Medical Training Authors: Hanjin Park Hee Tae Yu Tae-Hoon Kim Junbeom Park Jin-Kyu Park Ki-Woon Kang Jaemin Shim Jin-Bae Kim Jun Kim Eue-Keun Choi Hyung Wook Park Young Soo Lee Boyoung Joung Source Type: research
