• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Clopidogrel Is Associated with Reduced Likelihood of Aneurysmal Subarachnoid Hemorrhage: a Multi-Center Matched Retrospective Analysis
We present, to the best of our knowledge, the first large-scale multi-institutional analysis suggesting clopidogrel use is protective against intracranial aneurysm rupture. It is our hope that these data will guide future investigation, revealing the pathophysiologic underpinning of this association.
Source: Translational Stroke Research - July 20, 2023 Category: Neurology Source Type: research

Capsular warning syndrome and its clinical awareness and therapeutic approach: two case reports and a systematic review of the literature
ConclusionOur cases fit with the description of patients with partial recovery and risk factors (hypertension, diabetes, and smoking) in male patients. There is a lack of evidence regarding the best treatment option; dual antiplatelet therapy and anticoagulation therapy are strong contenders for a favorable result.
Source: Frontiers in Neurology - May 16, 2023 Category: Neurology Source Type: research

Hybrid Recanalization for the Treatment of Carotid/Vertebral In-stent Restenosis or Occlusion: Pilot Surgery Experiences From One Single Center
Conclusion : The hybrid technique maybe a safe and feasible treatment option to recanalize in-stent restenosis or occlusion with acceptable complications.
Source: Frontiers in Neurology - November 24, 2020 Category: Neurology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Hyperacute Carotid Stenting for Acute Ischemic Stroke After Systemic Thrombolysis with IV rt-PA (P1.282)
Conclusions:These 2 cases demonstrate a successful use of hyperacute carotid stenting and antiplatelet load in patients who received systemic thrombolysis with IV rt-PA. Both had excellent outcomes and no complications. This management may be considered in patients with similar clinical and imaging characteristics.Disclosure: Dr. Marulanda-Londoño has nothing to disclose. Dr. DeLeon-Bendetti has nothing to disclose. Dr. Ortiz has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Marulanda-Londono, E., DeLeon-Bendetti, A., Ortiz, G. Tags: Cerebrovascular Disease Case Reports I Source Type: research

Acute Ischemic Stroke as a Presenting Feature of Multiple Myeloma (P3.279)
Conclusions:Stroke is a leading and preventable cause of disability in the US adult population. The majority of strokes are due to atherosclerotic vascular or cardioembolic disease. Understanding the diagnostic work up of stroke and recognizing rare etiologies like MM is important for stroke prevention. This brings to light the importance of recognizing stroke as an initial presenting feature of multiple myeloma and of multiple myeloma as an important treatable etiology of stroke.Disclosure: Dr. Chung has nothing to disclose. Dr. Ramamoorthy has nothing to disclose. Dr. Kar has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chung, S., Ramamoorthy, R., Kar, J. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Association of multiple infarctions and ICAS with outcomes of minor stroke and TIA
Conclusions: The presence of multiple infarctions and ICAS were both associated with an increased risk of 90-day ischemic stroke in patients with minor stroke or TIA, while the presence of both imaging features had a combined effect. ClinicalTrials.gov identifier: NCT00979589.
Source: Neurology - March 12, 2017 Category: Neurology Authors: Pan, Y., Meng, X., Jing, J., Li, H., Zhao, X., Liu, L., Wang, D., Johnston, S. C., Wang, Y., Wang, Y., On behalf of the CHANCE Investigators Tags: All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control) ARTICLE Source Type: research

Phase I Experience of Safety of Eptifibatide in Select Patients with Elective Cerebral Aneurysm Embolization (P1.250)
Conclusion: IV Eptifibatide may represent another safe option for rapid and reversible antiplatelet therapy for reduction of thromboembolic complication associated with aneurysmal embolization in select patient population.Disclosure: Dr. Brar has nothing to disclose. Dr. Moussavi has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Korya has nothing to disclose. Dr. Chahal has nothing to disclose. Dr. Daniel has nothing to disclose. Dr. Samaan has nothing to disclose. Dr. Song has nothing to disclose. Dr. Hussain has nothing to disclose. Dr. Kirmani has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Daniel, J., Brar, J., Moussavi, M., Mehta, S., Korya, D., Chahal, H., Samaan, M., Song, Y.-B., Hussain, M., Kirmani, J. Tags: Aneurysms and Subarachnoid Hemorrhage Source Type: research

Intracranial Fibromuscular Dysplasia in a Middle-Aged Woman with Recurrent Ischemic Stroke (P4.388)
Conclusions: FMD is a rare disease and has very rarely been described in the intracranial arteries. This case illustrates the natural history and progression of FMD in this patient and elucidates the limited treatment options for preventing disease progression and secondary complications. FMD most predominantly affects younger to middle-aged females and if the disease process goes unrecognized it can have devastating consequences. It is important to continue research endeavors into the genetic and biologic determinants of FMD in order to develop better prevention and therapeutic strategies for this condition.Disclosure: Dr...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Beaton, N., Malik, A., Maque-Acosta, Y., Koch, S. Tags: Non-Atherosclerotic Arteriopathies Source Type: research

Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE
Conclusions: The results indicated higher rate of recurrent stroke in minor stroke or high-risk TIA patients with ICAS than in those without. However, there was no significant difference in the response to the 2 antiplatelet therapies between patients with and without ICAS in the CHANCE trial. Classification of evidence: This study provides Class II evidence that for patients with acute minor stroke or TIA with and without ICAS identified by MRA, clopidogrel plus aspirin is not significantly different than aspirin alone in preventing recurrent stroke.
Source: Neurology - September 28, 2015 Category: Neurology Authors: Liu, L., Wong, K. S. L., Leng, X., Pu, Y., Wang, Y., Jing, J., Zou, X., Pan, Y., Wang, A., Meng, X., Wang, C., Zhao, X., Soo, Y., Johnston, S. C., Wang, Y., For the CHANCE Investigators Tags: ARTICLE Source Type: research

Recurrent Intra-Luminal Aortic Thrombus And Ischemic Stroke In A Patient With Essential Thrombocythemia (P6.262)
CONCLUSIONS: This case highlights the importance of recognizing essential thrombocythemia as an entity that can lead to devastating complications, including acute coronary syndrome and either arterial and venous thrombosis. Early recognition and effective cytoreductive therapy are cornerstones to the prevention of recurrent embolism. This case demonstrates that Intra-luminal thrombus may resolve and reappear, and can vary greatly in its clinical consequences.Disclosure: Dr. Vela-Duarte has nothing to disclose. Dr. Flaster has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Vela-Duarte, D., Flaster, M. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Vascular Inflammation Imaging with 18F-FDG PET/CT for In-Stent Restenosis after Intracranial Stent Deployment in a Swine Model (S51.002)
Conclusions: This swine model is suitable for the testing of devices for the endovascular treatment of intracranial atherosclerosis. It can be a useful tool for the study of inflammation mechanisms of in-stent restenosis after intracranial stenting therapies.Disclosure: Dr. Shi has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Shi has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Chen has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Feng has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Shi, Z.-S., Liu, Z., Wang, J.-S., Liu, D.-H., Shi, X.-C., Zhang, X.-S., Chen, D.-J., Liu, Y., Liu, Y.-Q., Wang, Q.-Y., Feng, L. Tags: Cerebrovascular Disease and Interventional Neurology: Large Vessel Atherosclerotic Disease Source Type: research

A Markov model to compare the long-term effect of aspirin, clopidogrel and clopidogrel plus aspirin on prevention of recurrent ischemic stroke due to intracranial artery stenosis
Conclusion: To prevent recurrent stroke in patients with intracranial artery stenosis, especially in those patients with a history of TIA or coronary artery disease, medical therapy with clopidogrel plus aspirin should be considered in preference to aspirin alone.
Source: Neurology India - March 7, 2014 Category: Neurology Authors: Jinqiu YangLukui ChenNaveen ChitkaraQiang Xu Source Type: research