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Total 9822 results found since Jan 2013.

New‐onset diabetes mellitus after pediatric liver transplantation
Abstract In the first five yr after liver transplant, approximately one in 10 pediatric recipients will develop NODAT. Factors associated with higher risk for NODAT have been difficult to identify due to lack of uniformity in reporting and data collection. Limited studies have reported higher risk in those who are at an older age at transplant, those with high‐risk ethnic backgrounds, and in those with particular underlying conditions, such as CF and primary sclerosing cholangitis. Immunosuppressive medications, including tacrolimus, cyclosporine A, GC, and sirolimus, have been implicated as contributing to NODAT, to va...
Source: Pediatric Transplantation - May 29, 2015 Category: Transplant Surgery Authors: Molly O. Regelmann, Marina Goldis, Ronen Arnon Tags: Review Article Source Type: research

Pediatric obesity: Causes, symptoms, prevention and treatment.
Authors: Xu S, Xue Y Abstract Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults. Obe...
Source: Experimental and Therapeutic Medicine - February 4, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Barriers to participation in industry ‐sponsored clinical trials in pediatric type 2 diabetes
ConclusionsEfforts must be made to ease the burden of research participation on both pediatric T2D patients as well as pediatric endocrinologists
Source: Pediatric Diabetes - November 2, 2016 Category: Endocrinology Authors: Ryan Farrell, Kathleen Bethin, Georgeanna Klingensmith, William V. Tamborlane, Rose Gubitosi ‐Klug Tags: Original Article Source Type: research

Metformin Use May Reduce Mortality in Women With COVID - 19
In overall sample of men and women, metformin use was not linked to significantly reduced mortality
Source: Pulmonary Medicine News - Doctors Lounge - November 11, 2014 Category: Respiratory Medicine Tags: Endocrinology, Gynecology, Infections, Internal Medicine, Critical Care, Emergency Medicine, Nursing, Pharmacy, Pulmonology, Journal, Source Type: news

Metformin Use for T2DM May Reduce COVID - 19 Mortality
Odds of contracting COVID - 19, COVID - 19 - related mortality higher for individuals with diabetes
Source: Pulmonary Medicine News - Doctors Lounge - January 27, 2021 Category: Respiratory Medicine Tags: Endocrinology, Family Medicine, Geriatrics, Gynecology, Infections, Internal Medicine, Critical Care, Nursing, Pharmacy, Pulmonology, Journal, Source Type: news

Predictors of Death, Discharge ID ’ d for Diabetes Patients With COVID - 19
Younger age, routine metformin therapy, and longer symptom duration on admission positively linked to discharge
Source: Pulmonary Medicine News - Doctors Lounge - February 23, 2021 Category: Respiratory Medicine Tags: Endocrinology, Infections, Internal Medicine, Critical Care, Emergency Medicine, Nursing, Pharmacy, Pulmonology, Geriatrics, Journal, Source Type: news

Differences in the Management of Adolescents with Polycystic Ovary Syndrome across Pediatric Specialties
Conclusions: The variability observed among specialties may be due to differences in training, accounting for a range of comfort with aspects of PCOS. Formulation of consensus guidelines for diagnosis and management of PCOS are needed, along with broad educational efforts. By correctly diagnosing, screening for comorbidities, and managing PCOS appropriately during adolescence, providers may reduce the risk for long-term consequences.
Source: Journal of Pediatric and Adolescent Gynecology - March 25, 2013 Category: OBGYN Authors: Bethany Auble, Deborah Elder, Andrea Gross, Jennifer B. Hillman Tags: Original Studies Source Type: research

Restoring Insulin Secretion (RISE): Design of Studies of ss-cell Preservation in Prediabetes and Early Type 2 Diabetes Across the Lifespan.
ConclusionsRISE is determining whether medication or surgical intervention strategies can mitigate progressive ß-cell dysfunction in adults and youth with prediabetes or early type 2 diabetes. PMID: 24194506 [PubMed - as supplied by publisher]
Source: Diabetes Care - November 5, 2013 Category: Endocrinology Authors: Nadeau KJ, Mather KJ, Arslanian SA, Buchanan TA, Caprio S, Edelstein SL, Ehrmann DA, Savage PJ, Kahn SE Tags: Diabetes Care Source Type: research

Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup
Conclusion: Metformin poisoning with lactic acidosis appears to be amenable to extracorporeal treatments. Despite clinical evidence comprised mostly of case reports and suboptimal toxicokinetic data, the workgroup recommended extracorporeal removal in the case of severe metformin poisoning.
Source: Critical Care Medicine - July 17, 2015 Category: Emergency Medicine Tags: Review Articles Source Type: research

Metformin Poisoning: A Debate on Recommendations for Extracorporeal Treatment
No abstract available
Source: Critical Care Medicine - October 16, 2015 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Metformin tied to improved survival in diabetics with pancreatic cancer Metformin tied to improved survival in diabetics with pancreatic cancer
Patients with type 2 diabetes who are already taking metformin when they ' re diagnosed with pancreatic ductal adenocarcinoma (PDAC) may survive longer than those on other medications, according to a new study.Reuters Health Information
Source: Medscape Critical Care Headlines - August 10, 2016 Category: Intensive Care Tags: Pulmonary Medicine News Source Type: news

In vitro and in vivo investigation of PLA/PCL scaffold coated with metformin-loaded gelatin nanocarriers in regeneration of critical-sized bone defects
Publication date: Available online 28 June 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Mostafa Shahrezaee, Majid Salehi, Sara Keshtkari, Ahmad Oryan, Amir Kamali, Babak ShekarchiAbstractLarge bone defects constitute a major challenge in bone tissue engineering and usually fail to heal due to the incomplete differentiation of recruited mesenchymal stem cells (MSCs) into osteogenic precursor cells. As previously proposed, metformin (MET) induces differentiation of MSCs into osteoblastic lineages in vitro. We fabricated a Poly (lactic acid) and Polycaprolactone (PLA/PCL) scaffold to deliver metfor...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - July 5, 2018 Category: Nanotechnology Source Type: research

A Study of Associations Between Plasma Metformin Concentration, Lactic Acidosis, and Mortality in an Emergency Hospitalization Context
Objectives: To determine the plasma metformin concentration threshold associated with lactic acidosis and analyze the outcome in metformin-treated patients with lactic acidosis hospitalized in an emergency context. Design: A retrospective, observational, single-center study. Setting: Emergency department and ICUs at Amiens University Hospital (Amiens, France). Patients: All consecutive patients with data on arterial lactate and pH up to 12 hours before or after a plasma metformin assay within 24 hours of admission, over a 9.7-year period. Intervention: None. Measurements and Main Results:...
Source: Critical Care Medicine - November 22, 2020 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Therapeutic Strategy for Metformin-Associated Lactic Acidosis
No abstract available
Source: Critical Care Medicine - March 25, 2021 Category: Emergency Medicine Tags: Online Letters to The Editor Source Type: research