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PLGA-based microspheres loaded with metformin hydrochloride: modified double emulsion method preparation, optimization, characterization, and in vitro evaluation
Ann Pharm Fr. 2023 Sep 12:S0003-4509(23)00105-0. doi: 10.1016/j.pharma.2023.09.002. Online ahead of print.ABSTRACTThe modified solvent removal method was used to encapsulate metformin hydrochloride (MH) within poly(lactic-co-glycolic acid) (PLGA) microspheres. The study investigated the effect of varying polymer concentrations on the loading and release of the drug from the microspheres. The encapsulation process involved using a double emulsion method, resulting in microspheres with particle diameters ranging from approximately 4.4 µm to 2.7 µm. The study achieved high encapsulation efficiencies, ranging from 81% to 90%...
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Priyanka Chauhan Himanshu Paliwal Chetan Singh Chauhan Ankit Paliwal Source Type: research

Quantitative risk-benefit profiles of oral contraceptives, insulin sensitizers and antiandrogens for women with polycystic ovary syndrome: A model-based meta-analysis
This study aimed to quantitatively evaluate the effects of the aforementioned medications and to compare their risk-benefit profiles. Randomized controlled trials published until 14th March 2022 were searched in PubMed and Embase. A model-based meta-analysis was developed to examine the time-effect profiles of each medication. The maximal percentage change of the effect (Emax) and time to achieve half of Emax (T50) were estimated. Primary outcomes included menstruation, hirsutism score, free androgen index (FAI), body mass index (BMI), insulin sensitivity, and lipid profiles. Overall, 200 studies (9,685 patients and 385 ar...
Source: European Journal of Pharmaceutical Sciences - September 4, 2023 Category: Drugs & Pharmacology Authors: Zhe Tang Jing Guan Jue-Hui Mao Lu Han Juan-Juan Zhang Rui Chen Zheng Jiao Source Type: research

Quantitative risk-benefit profiles of oral contraceptives, insulin sensitizers and antiandrogens for women with polycystic ovary syndrome: a model-based meta-analysis
This study aimed to quantitatively evaluate the effects of the aforementioned medications and to compare their risk-benefit profiles. Randomized controlled trials published until 14th March, 2022 were searched in PubMed and Embase. A model-based meta-analysis was developed to examine the time-effect profiles of each medication. The maximal percentage change of the effect (Emax) and time to achieve half of Emax (T50) were estimated. Primary outcomes included menstruation, hirsutism score, free androgen index (FAI), body mass index (BMI), insulin sensitivity, and lipid profiles. Overall, 200 studies (9,685 patients and 385 a...
Source: European Journal of Pharmaceutical Sciences - September 4, 2023 Category: Drugs & Pharmacology Authors: Zhe Tang Jing Guan Jue-Hui Mao Lu Han Juan-Juan Zhang Rui Chen Zheng Jiao Source Type: research

Promising translatable pharmacological interventions for body weight management in individuals with severe mental illness - a narrative review
Expert Opin Pharmacother. 2023 Aug 31. doi: 10.1080/14656566.2023.2254698. Online ahead of print.ABSTRACTINTRODUCTION: Psychotropic medications, especially antipsychotics, have been consistently shown to cause weight gain in individuals with severe mental illness (SMI), a population inherently challenged with poor physical health. Consequently, compared to the general population, this contributes to an increased cardiometabolic burden, including the risk of type 2 diabetes, dyslipidemia, and hypertension. Furthermore, comorbid obesity leads to treatment nonadherence, decreased quality of life, and increased risk of relapse...
Source: Expert Opinion on Pharmacotherapy - September 1, 2023 Category: Drugs & Pharmacology Authors: Riddhita De Femin Prasad Nicolette Stogios Luisa Burin Bj ørn H Ebdrup Filip K Knop Margaret K Hahn Sri Mahavir Agarwal Source Type: research

Metformin and SGLT2i as First-line Combination Therapy in Type 2 Diabetes: A Real-world Study With a Focus on Ethnicity
Clin Ther. 2023 Aug 28:S0149-2918(23)00302-8. doi: 10.1016/j.clinthera.2023.07.026. Online ahead of print.ABSTRACTPURPOSE: Suboptimal glucose control early in the diagnosis of type 2 diabetes (T2D) is strongly associated with subsequent morbidity and mortality, termed the 'glycaemic legacy'. Additionally, it is known that Asian and Black individuals are at increased risk of T2D, and its associated complications compared to their White counterparts. However, ethnicity does not currently feature in the treatment algorithm of T2D, unlike in other cardiovascular disease states such as hypertension. We therefore sought to evalu...
Source: Clinical Therapeutics - August 30, 2023 Category: Drugs & Pharmacology Authors: Matthew Anson Sizheng Steven Zhao Hani Essa Philip Austin Gema Hern ández Ibarburu Gregory Y H Lip Uazman Alam Source Type: research

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