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A retrospective analysis of clinical features and treatment outcome in 21 patients with immunoglobulin M-related light-chain amyloidosis in Japan: a study from the Amyloidosis Research Committee
Int J Hematol. 2023 Jul 29. doi: 10.1007/s12185-023-03647-2. Online ahead of print.ABSTRACTWe retrospectively gathered data of 21 patients (13 male and 8 female; median age 65 years) diagnosed with immunoglobulin M (IgM)-related light-chain (AL) amyloidosis in Japan to investigate characteristics of IgM-AL amyloidosis and its optimal treatment strategy. Median IgM and difference free light chain (FLC) at diagnosis were 1257 mg/dl and 34.3 mg/l, respectively. Organ involvement was observed in the heart in 7 patients (33%), kidneys in 15 (71%), and lymph nodes in 5 (24%). Initial treatments were melphalan/dexamethasone in 7 ...
Source: International Journal of Hematology - July 29, 2023 Category: Hematology Authors: Shin-Ichi Fuchida Mizuki Ogura Tadao Ishida Hiroyuki Hata Hiroshi Handa Nagaaki Katoh Chiaki Nakaseko Kazutaka Sunami Yuta Katayama Hironobu Nobata Kazuiku Oshiro Shinsuke Iida Yoshiki Sekijima Hironobu Naiki Chihiro Shimazaki Source Type: research

Renal failure in multiple myeloma: Specific management issues
Bull Cancer. 2023 Feb 7:S0007-4551(23)00042-5. doi: 10.1016/j.bulcan.2022.12.015. Online ahead of print.ABSTRACTRenal impairment is common during multiple myeloma and persistent reduction in kidney function strongly affects prognosis. Cast nephropathy, by monoclonal free light chains precipitation with uromodulin in renal tubules, is the main cause of acute kidney injury in multiple myeloma. Kidney biopsy, although not necessary for diagnosis, allows assessment of renal prognosis according to the extent of cast formation, tubular atrophy and interstitial fibrosis. Prevention and early diagnosis of acute kidney injury are e...
Source: Bulletin du Cancer - February 9, 2023 Category: Cancer & Oncology Authors: M élanie Try St éphanie Harel Source Type: research

New immunosuppressive agents in transplantation
Presse Med. 2022 Oct 14:104142. doi: 10.1016/j.lpm.2022.104142. Online ahead of print.ABSTRACTImmunosuppressive agents have enabled the development of allogenic transplantation during the last 40 years, allowing considerable improvement in graft survival. However, several issues remain such as the nephrotoxicity of calcineurin inhibitors, the cornerstone of immunosuppressive regimens and/or the higher risk of opportunistic infections and cancers. Most immunosuppressive agents target T cell activation and may not be efficient enough to prevent allo-immunization in the long term. Finally, antibody mediated rejection due to d...
Source: Presse Medicale - October 17, 2022 Category: General Medicine Authors: Delphine Kervella Gilles Blancho Source Type: research

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