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Bavituximab decreases immunosuppressive myeloid-derived suppressor cells in newly diagnosed glioblastoma patients
DISCUSSION: Bavituximab has activity in newly diagnosed GBM and resulted in on-target depletion of intratumoral immunosuppressive MDSCs. Elevated pre-treatment expression of myeloid-related transcripts in GBM may predict response to bavituximab.PMID:37327319 | DOI:10.1158/1078-0432.CCR-23-0203
Source: Clinical Cancer Research - June 16, 2023 Category: Cancer & Oncology Authors: K Ina Ly Leland G Richardson Mofei Liu Alona Muzikansky Jonathan Cardona Kevin Lou Andrew L Beers Ken Chang James M Brown Xiaoyue Ma David A Reardon Isabel C Arrillaga-Romany Deborah A Forst Justin T Jordan Eudocia Q Lee Jorg Dietrich Lakshmi Nayak Patric Source Type: research

Pseudoprogression after glioma therapy: an update.
Authors: Galldiks N, Kocher M, Langen KJ Abstract INTRODUCTION: Initial diagnostics and follow-up of gliomas is usually based on contrast-enhanced MRI. However, the capacity of standard MRI to differentiate neoplastic tissue from posttherapeutic effects such as pseudoprogression is limited. Advanced neuroimaging methods may provide relevant additional information, which allow for a more accurate diagnosis especially in clinically equivocal situations. This review article focuses predominantly on PET using radiolabeled amino acids and advanced MRI techniques such as perfusion-weighted imaging (PWI) and summarizes the e...
Source: Expert Review of Neurotherapeutics - September 2, 2017 Category: Neurology Tags: Expert Rev Neurother Source Type: research

MR perfusion-weighted imaging in the evaluation of high-grade gliomas after treatment: a systematic review and meta-analysis
Conclusions. PWI-derived thresholds separating viable tumor from treatment changes demonstrate relatively good accuracy in individual studies. However, because of significant variability in optimal reported thresholds and other limitations in the existing body of literature, further investigation and standardization is needed before implementing any particular quantitative PWI strategy across institutions.
Source: Neuro-Oncology - December 26, 2016 Category: Cancer & Oncology Authors: Patel, P., Baradaran, H., Delgado, D., Askin, G., Christos, P., John Tsiouris, A., Gupta, A. Tags: Clinical Investigation Source Type: research

Abstract 5222: Endothelial plasticity generates aberrant angiogenesis and therapy resistance in glioblastoma
Overgrown, abnormal vasculature characterizes the microenvironment that fuels cancer progression and induces therapeutic resistance. Here we reveal that endothelial plasticity drives excessive and abnormal tumor angiogenesis. Glioblastoma multiforme (GBM) is among the most lethal of human malignancies, distinguished by prominent vascularity and extreme vascular abnormality. We identify endothelial fibro-transformation (Endo-FT) in GBM, contributing significantly to aberrant vascularization, tumor progression, and therapeutic resistance. Utilizing human GBM specimens and allograft and genetic murine GBM models driven by RCA...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Huang, M., Fan, Y. Tags: Tumor Biology Source Type: research

Dopamine induces growth inhibition and vascular normalization through reprograming M2-polarized macrophages in rat C6 glioma.
Abstract Dopamine (DA), a monoamine catecholamine neurotransmitter with antiangiogenic activity, stabilizes tumor vessels in colon, prostate and ovarian cancer, thus increases chemotherapeutic efficacy. Here, in the rat C6 glioma models, we investigated the vascular normalization effects of DA and its mechanisms of action. DA (25, 50 mg/kg) inhibited tumor growth, while a precursor of DA (levodopa) prolonged the survival time of rats bearing orthotopic C6 glioma. DA improved tumor perfusion, with significant effects from day 3, and a higher level at day 5 to 7. In addition, DA decreased microvessel density and hyp...
Source: Toxicology and Applied Pharmacology - March 25, 2015 Category: Toxicology Authors: Qin T, Wang C, Chen X, Duan C, Zhang X, Zhang J, Chai H, Tang T, Chen H, Yue J, Li Y, Yang J Tags: Toxicol Appl Pharmacol Source Type: research