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Real-World Treatment Patterns Among French Patients With Metastatic Castration-Resistant Prostate Cancer Under Abiraterone or Enzalutamide
CONCLUSION: Our study suggested fairly similar patterns between ABI and ENZ initiation. The cluster of patients with active treatment discontinuation needs to be further investigated, as well as factors influencing therapeutic choice. Better understanding for the use of second-generation hormone therapy in mCRPC in real life, could improve its implementation by clinicians in the early stages of prostate cancer.PMID:37188606 | DOI:10.1016/j.clgc.2023.04.004
Source: Clinical Prostate Cancer - May 15, 2023 Category: Cancer & Oncology Authors: Lucie-Marie Scailteux S ébastien Vincendeau Gwena ëlle Gravis Romain Mathieu Fr édéric Balusson Sandrine Kerbrat Emmanuel Oger Source Type: research

Real-World Treatment Patterns Among Patients With Metastatic Castration-Resistant Prostate Cancer: Results From an International Study
CONCLUSIONS: These findings suggest that physicians consider mCSPC treatment history when making first-line treatment decisions in mCRPC. Further studies are needed to better understand optimal treatment sequencing, especially as new treatments emerge.PMID:37014097 | DOI:10.1093/oncolo/oyad046
Source: The Oncologist - April 4, 2023 Category: Cancer & Oncology Authors: Pedro C Barata Andrea Leith Amanda Ribbands Rachel Montgomery Matthew Last Bhakti Arondekar Jasmina Ivanova Alexander Niyazov Source Type: research

Promoter hypomethylation and overexpression of TSTD1 mediate poor treatment response in breast cancer
We examined paired tissues from Taiwanese patients and observed that 65.09% and 68.25% of patients exhibited TSTD1 hypomethylation and overexpression, respectively. A significant correlation was found between TSTD1 hypomethylation and overexpression in Taiwanese (74.2%, p = 0.040) and Western (88.0%, p < 0.001) cohorts. High expression of TSTD1 protein was observed in 68.8% of Taiwanese and Korean breast cancer patients. Overexpression of TSTD1 in tumors of breast cancer patients was significantly associated with poor 5-year overall survival (p = 0.021) and poor chemotherapy response (p = 0.008). T47D cells treated with...
Source: Frontiers in Oncology - November 7, 2022 Category: Cancer & Oncology Source Type: research

Treatment Intensification Patterns and Utilization in Patients with Metastatic Castration-Sensitive Prostate Cancer
CONCLUSION: Both medical oncology and urology providers need to improve their treatment intensification efforts for men with mCSPC to increase their patients' overall survival.PMID:35864053 | DOI:10.1016/j.clgc.2022.06.017
Source: Clinical Prostate Cancer - July 21, 2022 Category: Cancer & Oncology Authors: Elisabeth I Heath Gregory E Dyson Frank C Cackowski Jason Hafron Isaac Powell Source Type: research

French ccAFU guidelines - update 2020-2022: prostate cancer.
CONCLUSION: - These updated french guidelines will contribute to increase the level of urological care for the diagnosis and treatment for prostate cancer. PMID: 33349424 [PubMed - in process]
Source: Progres en Urologie - December 24, 2020 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

The Prognostic Value of Androgen Receptor Splice Variant 7 in Castration-Resistant Prostate Cancer Treated With Novel Hormonal Therapy or Chemotherapy: A Systematic Review and Meta-analysis
ConclusionNHT treatment increased AR-V7 positive proportion whereas chemotherapy decreased it. Moreover, AR-V7 positivity correlated with lower PSA response, poorer PFS, and OS in CRPC treated with NHT, and shorter OS in patients receiving chemotherapy.
Source: Frontiers in Oncology - November 30, 2020 Category: Cancer & Oncology Source Type: research

Overexpression of ASPM, CDC20, and TTK Confer a Poorer Prognosis in Breast Cancer Identified by Gene Co-expression Network Analysis
In conclusion, our WGCNA analysis identified candidate prognostic biomarkers for further basic and clinical researches. Introduction Breast cancer is a frequently diagnosed malignancy and the leading cause of cancer death among females around the world, accounting for 24% of cancer diagnoses and 15% of cancer deaths in females. According to Global Cancer Statistics 2018, there will be nearly 2.1 million new cases diagnosed globally, with ~62 thousand deaths. The incident rates of breast cancer increased in most developing countries during last decades, resulting from a combination of social and economic facto...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research