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Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis
CONCLUSION: ASM-mediated autophagy activation induces osteoblast ferroptosis under HG conditions through the degradation of GPX4, providing a novel mechanistic insight into the treatment and prevention of T2DOP.PMID:37710183 | DOI:10.1186/s10020-023-00724-4
Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Yun-Xia Du Yan-Tao Zhao Yong-Xin Sun Ai-Hua Xu Source Type: research

Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner
In this study, we examined the effect of varying doses and exposure times of hesperetin on MCF-7 and MDA-MB-231 cancer cells, as well as MCF-10A normal cells. By using MTT assay, real-time PCR, western blot, and flow cytometry, we determined the effects of Hst on cell viability, ROS levels, and markers of cell death. Furthermore, molecular docking was used to identify Hst targets that might be involved in ROS-dependent cell death. According to the results, different concentrations of Hst induced different modes of cell death at specific ROS levels. Paraptosis occurred in all cell lines at concentration ranges of IC35 to IC...
Source: Chemico-Biological Interactions - July 24, 2023 Category: Molecular Biology Authors: Mohammad Rasoul Samandari-Bahraseman Babak Khorsand Sara Zareei Massoud Amanlou Hanieh Rostamabadi Source Type: research

Involvement of the JNK/HO ‑1/FTH1 signaling pathway in nanoplastic‑induced inflammation and ferroptosis of BV2 microglia cells
In conclusion, NPs could induce inflammatory responses and ferroptosis in BV2 cells. JNK/HO‑1 mediated ferroptosis may serve an important role in the toxicity of microglia induced by NPs. This study provided novel evidence for the toxic effects of NPs and highlighted a theoretical mechanistic basis for safe prevention and treatment of plastic pollution‑induced neurotoxicity.PMID:37264973 | DOI:10.3892/ijmm.2023.5264
Source: Molecular Medicine - June 2, 2023 Category: Molecular Biology Authors: Jiayin Sun Yihua Wang Yilun Du Wanxin Zhang Zuodong Liu Jin Bai Guanqun Cui Zhongjun Du Source Type: research

Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review)
Int J Mol Med. 2023 Jun;51(6):53. doi: 10.3892/ijmm.2023.5256. Epub 2023 May 19.ABSTRACTFerroptosis, a novel form of regulated cell death, is characterized by the accumulation of labile iron and lipid peroxidation, and the excessive production of reactive oxygen species (ROS). Although ferroptosis lies at the center of crucial biological activities involving O2, iron and polyunsaturated fatty acids (PUFAs), which are essential for cell proliferation and growth, the interaction between these molecules could also mediate the accumulation of toxic levels of ROS and lipid peroxides, which can then cause damage to cellular memb...
Source: Molecular Medicine - May 19, 2023 Category: Molecular Biology Authors: Dickson Kofi Wiredu Ocansey Jintao Yuan Zhiping Wei Fei Mao Zhaoyang Zhang Source Type: research

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