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Deep brain stimulation for movement disorders after stroke: a systematic review of the literature
CONCLUSIONS: This is the first systematic review of DBS for poststroke movement disorders. Overall, most studies to date have been case reports and small series reporting heterogeneous patients and surgical strategies. This review suggests that DBS for movement disorders after a stroke has the potential to be effective and safe for diverse patients, and DBS may be a feasible option to improve function even years after a stroke.PMID:36308482 | DOI:10.3171/2022.8.JNS221334
Source: Journal of Neurosurgery - October 29, 2022 Category: Neurosurgery Authors: Mitch R Paro Michal Dyrda Srinath Ramanan Grant Wadman Stacey-Ann Burke Isabella Cipollone Cory Bosworth Sarah Zurek Patrick B Senatus Source Type: research

Predictors of 30-day hospital readmission after mechanical thrombectomy for acute ischemic stroke.
CONCLUSIONS: The study data demonstrate that hypertension, length of hospital stay, and hemorrhagic conversion were predictors of 30-day hospital readmission in stroke patients after mechanical thrombectomy. Infection was the most common cause of 30-day readmission, followed by cardiac and cerebrovascular diagnoses. These results therefore may serve to identify patients within the stroke population who require increased surveillance following discharge to reduce complications and unplanned readmissions. PMID: 32357335 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - April 30, 2020 Category: Neurosurgery Authors: Mouchtouris N, Al Saiegh F, Valcarcel B, Andrews CE, Fitchett E, Nauheim D, Moskal D, Herial N, Jabbour P, Tjoumakaris SI, Sharan AD, Rosenwasser RH, Gooch MR Tags: J Neurosurg Source Type: research

Woodrow Wilson's hidden stroke of 1919: the impact of patient-physician confidentiality on United States foreign policy.
Abstract World War I catapulted the United States from traditional isolationism to international involvement in a major European conflict. Woodrow Wilson envisaged a permanent American imprint on democracy in world affairs through participation in the League of Nations. Amid these defining events, Wilson suffered a major ischemic stroke on October 2, 1919, which left him incapacitated. What was probably his fourth and most devastating stroke was diagnosed and treated by his friend and personal physician, Admiral Cary Grayson. Grayson, who had tremendous personal and professional loyalty to Wilson, kept the severit...
Source: Neurosurgical Focus - July 1, 2015 Category: Neurosurgery Authors: Menger RP, Storey CM, Guthikonda B, Missios S, Nanda A, Cooper JM Tags: Neurosurg Focus Source Type: research

O-004 A multicenter study evaluating the frequency and burden of mechanical thrombectomy on stroke centers
Conclusion This is the first study to quantify the time requirement of mechanical thrombectomy and the call burden on neurointerventional physicians at stroke centers. Over a three month period at 10 stroke centers across the United States, mechanical thrombectomy procedures occurred once every 5 days on average, although nearly 60% occurred during non-work hours. As ELVO awareness increases, thrombectomy call has important operational implications for hospitals implementing stroke call coverage. Abstract O-004 Figure 1 Disclosures T. Wilson: None. T. Kim: None. C. Frey: None. A. Spiotta: None. R. de Leacy: None. J. M...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Wilson, T., Kim, T., Frey, C., Spiotta, A., Leacy, R. d., Mocco, J., Albuquerque, F., Ducruet, A., Cheema, A., Arthur, A., Srinivasan, V., Kan, P., Mokin, M., Dumont, T., Rai, A., Leslie-Mazwi, T., Hirsch, J., Singh, J., Singh, J., Wolfe, S., Fargen, K. Tags: Oral Abstracts Source Type: research

E-006 Feasibility and safety of mechanical thrombectomy in stroke patients presenting with distal ACA occlusions - insights from star
ConclusionIn this multicenter study, MT for distal ACA occlusions in the A2/A3 segments seem to be feasible and associated with low complication and symptomatic hemorrhage rates. Future studies are needed to compare the functional outcome of MT versus medical management for stroke patients presenting with A2/A3 occlusions.Disclosures D. Pullmann: None. E. Almallouhi: None. S. Al Kasab: None. A. Alawieh: None. R. Chalhoub: None. R. Starke: None. R. De Leacy: None. D. Raper: None. A. Rai: None. T. Dumont: None. S. Wolfe: None. P. Jabbour: None. C. Ogilvy: None. M. Park: None. M. Levitt: None. A. Polifka: None. R. Crowley: No...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Pullmann, D., Almallouhi, E., Al Kasab, S., Alawieh, A., Chalhoub, R., Starke, R., De Leacy, R., Raper, D., Rai, A., Dumont, T., Wolfe, S., Jabbour, P., Ogilvy, C., Park, M., Levitt, M., Polifka, A., Crowley, R., Arthur, A., Osbun, J., Crosa, R., Maier, I Tags: Electronic poster abstracts Source Type: research

E-096 COVID status is related to clot burden during thrombectomy in acute stroke patients
ConclusionOf 230 patients included in this interim analysis across 24 centers in the United States, between 02/2021 and 01/2022, 16 patients had a history of COVID. Comparing COVID-positive to non-positive, patients with COVID were younger (median 66.5 years vs 71.5 years, p 0.042), and had more intracranial clot by weight (median 101.0 mg vs 42.0 mg, p 0.047). There was a trend toward COVID positive patients to have more clot volume (median 180 cc vs 77.5 cc p 0.08), suggesting the difference was a higher clot burden instead of more density to the thrombus. These results suggest different histopathological characteristics...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Fraser, J., Dabney, A., Vicari, J., Rivet, D., Woodward, B., Nanda, A., Fiorella, D., Baltan, S., Sohrabji, F., Pennypacker, K., Kellner, C. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

O-016 Aspiration thrombectomy for acute ischemic stroke patients presenting after 6 hours
ConclusionFor patients with late presentation stroke, aspiration thrombectomy with the Penumbra System in anterior circulations is safe and effective. Rates of good functional outcome and all-cause mortality compare favorably to the DAWN and DEFUSE-3 medical management arms.Disclosures A. Hassan: 2; C; GE Healthcare, Genentech, Medtronic, Microvention, Penumbra, Stryker, Cerenovus, Viz.ai, Balt, Scientia. 3; C; GE Healthcare, Genentech, Medtronic, Microvention, Penumbra, Stryker, Cerenovus, Viz.ai, Balt, Scientia. J. Fifi: 1; C; Microvention, Penumbra, Stryker. 2; C; Microvention, Stryker. 4; C; Imperative Care. O. Zaidat:...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Hassan, A., Fifi, J., Zaidat, O. Tags: Oral abstracts Source Type: research

Mechanical thrombectomy beyond the circle of Willis: efficacy and safety of different techniques for M2 occlusions
Conclusion Stent-retrievers and a combined approach for M2 occlusions seem more effective than direct aspiration, but with higher rates of iSAH. This leads to no detectable difference in clinical outcome at 3 months.
Source: Journal of NeuroInterventional Surgery - May 13, 2022 Category: Neurosurgery Authors: Renieri, L., Valente, I., Dmytriw, A. A., Puri, A. S., Singh, J., Nappini, S., Nencini, P., Kaliaev, A., Abdalkader, M., Alexandre, A., Garignano, G., Vivekanandan, S., Fong, R. P., Parra-Farinas, C., Spears, J., Gomez-Paz, S., Ogilvy, C., Regenhardt, R. Tags: Ischemic stroke Source Type: research

E-123 Evaluation of safety and efficacy of transradial access for mechanical thrombectomy inacute ischemic stroke - A single center experience
ConclusionTransradial access for mechanical thrombectomy in acute ischemic stroke is a primary access in tortuous vasculature/posterior circulation strokes and is a good alternative to the femoral approach. This vascular access is especially helpful in patients with posterior circulation strokes, on anticoagulation or with large body habitus.Disclosures A. Kuhn: None. J. Singh: None. K. de Macedo Rodrigues: None. F. Massari: None. F. Massari: None. M. Gounis: 1; C; National Institutes of Health (NIH), the United States – Israel Binational Science Foundation, Anaconda, ApicBio, Axovant, Cerenovus, Cook Medical, Gentui...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Kuhn, A., Singh, J., de Macedo Rodrigues, K., Massari, F., Massari, F., Gounis, M., Puri, A. Tags: Electronic poster abstracts Source Type: research

E-040 Factors associated with failed mechanical thrombectomy in acute ischemic stroke
ConclusionFailed MT was encountered in approximately 12% of cases. The most common location of failed MT was intracranial and this was predominantly due to ICAS. Further studies to evaluate better treatment modalities of ICAS related LVO are warranted.Disclosures O. Lajthia: None. H. Ali: None. R. Neyes: None. E. Almallouhi: None. R. Chalhoub: None. K. Kicielinski: None. J. Lena: None. M. Sattur: None. G. Porto: None. A. Spiotta: None. S. Al Kasab: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lajthia, O., Ali, H., Neyes, R., Almallouhi, E., Chalhoub, R., Kicielinski, K., Lena, J., Sattur, M., Porto, G., Spiotta, A., Al Kasab, S. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-147 Ephrin receptor beta 1 single nucleotide polymorphisms in association with age in acute stroke patients undergoing thrombectomy
Conclusion193 patients were included in this interim analysis across 23 centers in the United States, between 02/2021 and 11/2021. For the EPHB1 SNP (rs13073658), Table 1 shows the numbers and proportions of patients with varying expressions of the SNP. While no patients 50 or older were homozygous for the SNP, 16% of those under 50 years old were. The potential relationship between EPHB1 SNP and stroke in younger patients requires further evaluation.Abstract E-147 Table 1Disclosures J. Fraser: 1; C; University of Kentucky, American Heart Association. 2; C; Stream Biomedical, Penumbra, Medtronic. 4; C; Fawkes Biotechnology...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Fraser, J., Dabney, A., Vicari, J., Rivet, D., Woodward, B., Nanda, A., Fiorella, D., Baltan, S., Sohrabji, F., Pennypacker, K., Kellner, C. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

DEFUSE-3 Trial: Reinforcing Evidence for Extended Endovascular Intervention Time Window for Ischemic Stroke
The incidence of ischemic stroke in the United States is 3.29 per 1000 persons per year, making it the first and fourth greatest causes of disability and mortality, respectively.1 Previous randomized clinical trials (RCTs) investigating acute ischemic stroke (AIS) due to large-vessel occlusion (LVO) have shown that endovascular intervention is clinically beneficial when performed within 6 hours of onset.2-7 A few of these RCTs had perfusion imaging inclusion criteria, showing superior results when compared with similar RCTs without such criteria.
Source: World Neurosurgery - February 17, 2018 Category: Neurosurgery Authors: Dallas L. Sheinberg, David J. McCarthy, Eric C. Peterson, Robert M. Starke Tags: News and Opinion Source Type: research

Trends in acute ischemic stroke treatments and mortality in the United States from 2012 to 2018
CONCLUSIONS: From 2012 to 2018, use of tPA and MT increased significantly, irrespective of age, while mortality decreased in the entire AIS population. The most dramatic decrease in mortality was seen in the MT-treated population. Age-standardized mortality improved only in patients older than 70 years, with no change in younger patients.PMID:34198248 | DOI:10.3171/2021.4.FOCUS21117
Source: Neurosurgical Focus - July 1, 2021 Category: Neurosurgery Authors: Sharath Kumar Anand William J Benjamin Arjun Rohit Adapa Jiwon V Park D Andrew Wilkinson Badih J Daou James F Burke Aditya S Pandey Source Type: research

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