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Metabolism Pathways of Major Therapeutics for Treating Monkeypox Mono- and Co-infection with Human Immunodeficient Virus or SARS-CoV-2
Curr Drug Metab. 2023 Jun 7. doi: 10.2174/1389200224666230607124102. Online ahead of print.ABSTRACTMonkeypox is a zoonotic viral disease and remains endemic in tropical regions of Central and West Africa. Since May of 2022, cases of monkeypox have soared and spread worldwide. Confirmed cases have shown no travel history to the endemic regions as seen in the past. The World Health Organization declared monkeypox a global public health emergency in July 2022, and the United States government followed suit one month later. The current outbreak, in contrast to traditional epidemics, has high coinfection rates, particularly wit...
Source: Current Drug Metabolism - June 8, 2023 Category: Drugs & Pharmacology Authors: Daisy Yan Bingfang Yan Source Type: research

Repurposed drug battles ‘brain-eating’ amoeba
In the summer of 2021, a 54-year-old man was brought to a hospital in Northern California after an unexplained seizure. When an MRI revealed a mysterious mass in the left side of his brain, he was transferred to the University of California, San Francisco (UCSF), Medical Center. A brain biopsy and other tests revealed not a tumor, but an incredibly rare infection of the central nervous system caused by the amoeba Balamuthia mandrillaris . One of several “brain-eating” amoebae that occasionally spark headlines, the pathogen kills more than 90% of people who contract it. But despite initial setbacks, the patie...
Source: Science of Aging Knowledge Environment - February 3, 2023 Category: Geriatrics Source Type: research

Clinical Use of Tecovirimat (Tpoxx) for Treatment of Monkeypox Under an Investigational New Drug Protocol - United States, May-August 2022
MMWR Morb Mortal Wkly Rep. 2022 Sep 16;71(37):1190-1195. doi: 10.15585/mmwr.mm7137e1.ABSTRACTCurrently, no Food and Drug Administration (FDA)-approved treatments for human monkeypox are available. Tecovirimat (Tpoxx), however, is an antiviral drug that has demonstrated efficacy in animal studies and is FDA-approved for treating smallpox. Use of tecovirimat for treatment of monkeypox in the United States is permitted only through an FDA-regulated Expanded Access Investigational New Drug (EA-IND) mechanism. CDC holds a nonresearch EA-IND protocol that facilitates access to and use of tecovirimat for treatment of monkeypox.§...
Source: MMWR Morb Mortal Wkl... - September 15, 2022 Category: Epidemiology Authors: Kevin O'Laughlin Farrell A Tobolowsky Riad Elmor Rahsaan Overton Siobh án M O'Connor Inger K Damon Brett W Petersen Agam K Rao Kevin Chatham-Stephens Patricia Yu Yon Yu CDC Monkeypox Tecovirimat Data Abstraction Team Source Type: research

Malaria Surveillance - United States, 2018
This report summarizes confirmed malaria cases in persons with onset of illness in 2018 and trends in previous years.DESCRIPTION OF SYSTEM: Malaria cases diagnosed by blood smear microscopy, polymerase chain reaction, or rapid diagnostic tests are reported to local and state health departments through electronic laboratory reports or by health care providers or laboratory staff members directly reporting to CDC or health departments. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), the National Notifiable Dis...
Source: MMWR Surveill Summ - September 1, 2022 Category: Epidemiology Authors: Kimberly E Mace Naomi W Lucchi Kathrine R Tan Source Type: research

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