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Specialty: General Medicine
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Total 273 results found since Jan 2013.

Antiplatelet therapy in secondary ischemic stroke prevention - a short review.
In conclusion, we can say that current recommendations focused primarily on the therapy with aspirin for the secondary prevention of stroke in patients that presented vascular events, such as ischemic stroke of non-cardioembolic cause or transient ischemic attack and, as appropriate, aspirin plus dipyridamol or clopidogrel. The new therapy with ticagrelor in secondary stroke prevention seems to be promising, but more randomized clinical trials are needed to accurately assess the safety and efficacy of this new antiplatelet drug. PMID: 31658310 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - October 29, 2019 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Cervical adenocarcinoma generator of procoagulant status and ischemic stroke.
We present the case of a 44-years-old patient undergoing early menopause, who was diagnosed with cervical tumor of the serous adenocarcinoma type. The patient underwent external radiotherapy, and, in the seventh day of treatment, she suffered a frontal-temporal-parietal ischemic stroke with left hemiplegia. The blood testing highlighted procoagulant products (double fibrinogen compared to normal values, deficit of antithrombin and a high number of thrombocytes). The patient received neurological and rehabilitation treatment, at first with Heparin, followed by the administration of an antiaggregant. During this treatment, t...
Source: Romanian Journal of Morphology and Embryology - March 23, 2018 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Expression patterns of aquaporins 1 and 4 in stroke.
Authors: Roşu GC, Pirici I, Istrate-Ofiţeru AM, Iovan L, Tudorică V, Mogoantă L, Gîlceavă IC, Pirici D Abstract Ischemic stroke occurs through embolic or thrombotic obliteration of an artery from cerebral circulation and represents over 80% of all stroke cases. One of the fiercest complications after stroke is edema, which results from imbalanced water diffusion around the blood vessels walls. Water diffusion around blood vessel walls occurs physiologically mainly through two protein-formed pores, namely aquaporins (AQPs) 1 and 4. Here, we compare for the first time the expression patterns and colocalization ...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Remote Ischemic Conditioning in Acute Ischemic Stroke - A Clinical Trial Design.
This study aims to explore the efficiency and safety of remote ischemic conditioning during the first five days following in patients who are ineligible for reperfusion treatment (intravenous thrombolysis or/and mechanical thrombectomy). We hypothesized that this intervention would reduce the infarct size (neuroprotection in the reperfusion window) and improve functional recovery. We aim to conduct a double-blind controlled trial, multicenter in two hospitals in Romania. Two hundred patients with acute ischemic stroke randomly divided into an experimental group and a control group will be included. The subjects in the expe...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Clinical manifestations and morphological changes in one case with post-stroke Kl üver-Bucy syndrome.
We present the case of a 71-year-old right-handed male, admitted to the Department of Neurology, Emergency County Hospital of Arad, Romania, on November 2015, with a rare case of Klüver-Bucy syndrome (KBS), following an ischemic stroke of the right temporal lobe, which was previously diagnosed in December 2014 and was treated accordingly. At the moment of second hospital admission, the patient was found somnolent and confused at home, with traumatic signs of biting of the tongue and urine emission. A couple days after admission, our patient became alert and presented hypersexuality, hypermetamorphosis, increased oral tend...
Source: Romanian Journal of Morphology and Embryology - July 23, 2017 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

A rare cause of ischemic stroke: cardiac myxoma. Case report and review of literature.
Authors: Mustafa ER, Tudoraşcu DR, Giucă A, Toader DM, Foarfă MC, Puiu I, Istrate-Ofiţeru AM Abstract A 46-year-old female diagnosed several years ago with arterial hypertension and an ischemic stroke with significant recovery was admitted for dyspnea on usual physical activity and fatigue. Physical examination revealed signs of heart failure with crackles on both lung bases, distented jugular veins, accentuated pulmonic valve closure (P2) and tricuspid regurgitation murmur. Echocardiography identified a large tumor in the left atrium, suggestive of atrial myxoma, which caused a severe functional mitral stenosi...
Source: Romanian Journal of Morphology and Embryology - December 13, 2018 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Multiple congenital anomalies of carotid and vertebral arteries in a patient with an ischemic stroke in the vertebrobasilar territory. Case report and review of the literature.
This report describes the case of a 68-year-old man who was admitted in our Clinic for an acute ischemic stroke in the vertebrobasilar territory. Extracranial color-coded duplex sonography (CCDS) and computed tomography angiography revealed a combination of congenital anomalies of the neck arteries: left internal carotid artery hypoplasia, left common carotid artery hypoplasia, right vertebral artery hypoplasia and the emergence of the left vertebral artery directly from the aortic arch. The aim of this article is to emphasize the value of CCDS as an accurate, non-invasive method of assessing the neck arteries and, also, t...
Source: Romanian Journal of Morphology and Embryology - March 10, 2019 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Morpho-functional and radiological approach of poststroke seizures.
In this study, the ideal patient should be the patient diagnosed for the first time with temporal lobe epilepsy, followed longitudinally by high-resolution imaging techniques. Studying topography and morphopathology of poststroke sequelae can lead to an increase in accuracy prediction of epilepsy after it. PMID: 33544805 [PubMed - as supplied by publisher]
Source: Romanian Journal of Morphology and Embryology - February 7, 2021 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Toxicity and health impact of nanoparticles. Basic biology and clinical perspective.
Authors: Olaru DG, Olaru A, Kassem GH, Popescu-Drigă MV, Pinoşanu LR, Dumitraşcu DI, Popescu EL, Hermann DM, Popa-Wagner A Abstract Stroke has limited restorative treatment options. In search of new therapeutic strategies for the ischemic brain, cell-based therapies offered new hope, which has been, in the meanwhile, converted into a more realistic approach recognizing difficulties related to unfavorable environments causing low survival rates of transplanted neuronal precursors. Stem cell therapies are based on the transplantation of neuronal precursor cells (NPCs), adult stem cells propagated in cell culture o...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial
This study was a two-arm, prospective, international, cluster-randomised, controlled trial. Patients were included who had atrial fibrillation and an indication for oral anticoagulation. Clusters were randomised (1:1) to receive a quality improvement educational intervention (intervention group) or usual care (control group). Randomisation was carried out centrally, using the eClinicalOS electronic data capture system. The intervention involved education of providers and patients, with regular monitoring and feedback. The primary outcome was the change in the proportion of patients treated with oral anticoagulants from bas...
Source: The Lancet - August 29, 2017 Category: General Medicine Source Type: research

Giant left atrial myxoma - literature review and case presentation
We present the case of a 38-year-old patient who experienced four recurrent transient ischemic attacks and strokes. At the fourth cerebrovascular event, echocardiography was performed and it revealed a giant tumor located in the left atrium that was surgically removed. Pathological examination confirmed the diagnosis of cardiac myxoma. The postoperative evolution was favorable, both from a neurological and cardiac point of view. Although cardiac myxomas represent a rare cause of transient ischemic attacks and stroke, they must be considered as part of the assessment protocol for cerebrovascular events.PMID:35024724 | DOI:10.47162/RJME.62.2.02
Source: Romanian Journal of Morphology and Embryology - January 13, 2022 Category: General Medicine Authors: Victor Cornel Raicea Hora ţiu Suciu Andrei Dan Raicea Gheorghe Cosmin Macarie Tibor Mezei Maria Smaranda Maier Source Type: research