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Vaccination: Hepatitis Vaccine
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Total 622 results found since Jan 2013.
Establishment of a robust rat hepatitis E virus fecal-oral infection model and validation for antiviral studies
Antiviral Res. 2023 Jul 12:105670. doi: 10.1016/j.antiviral.2023.105670. Online ahead of print.ABSTRACTThe hepatitis E virus (HEV) is a major cause of hepatitis, with an estimated 3.3 million symptomatic cases annually. There is no HEV-specific treatment besides the off-label use of ribavirin and a vaccine is only available in China and Pakistan. To aid the development of therapeutic and preventive strategies, there is a need for convenient HEV infection models in small laboratory animals. To this end, we make use of the rat hepatitis E virus. Human infections with this virus have been reported in recent years, making it a...
Source: Antiviral Research - July 14, 2023 Category: Virology Authors: Xin Zhang Niels Cremers Stijn Hendrickx Yannick Debing Tania Roskams Lotte Coelmont Johan Neyts Suzanne J F Kaptein Source Type: research
Use of catch-up vaccinations in the second year of life (2YL) platform to close immunity gaps: A secondary DHS analysis in Pakistan, Philippines, and South Africa
CONCLUSION: Small to modest vaccine coverage improvements occurred in all three countries through catch-up vaccination in 2YL but many missed opportunities for vaccination continue to occur. Using the 2YL platform can increase coverage and close immunity gaps, but immunization programmes need to change policies, practices, and monitor catch-up vaccination to maximize the potential.PMID:36396512 | DOI:10.1016/j.vaccine.2022.10.040
Source: Vaccine - November 17, 2022 Category: Allergy & Immunology Authors: Porcia Manandhar Kathleen Wannemuehler M Carolina Danovaro-Holliday Laura Nic Lochlainn Stephanie Shendale Samir V Sodha Source Type: research
Phylogenetic and drug- and vaccine-resistance profiles of Hepatitis B Virus among children with HIV co-infection in Pakistan
CONCLUSION: Our study suggests ongoing transmission of HBV D1 and D2 sub-genotypes in the HIV-1 co-infected population, likely nosocomially, given common routes of HVB and HIV-1 transmission. The prevalence of major HBV drug- and vaccine-resistant mutations remains low. Surveillance for further transmissions and the possible emergence of major drug- or vaccine-resistant variants is required.PMID:36179949 | DOI:10.1016/j.meegid.2022.105371
Source: Infection, Genetics and Evolution - September 30, 2022 Category: Genetics & Stem Cells Authors: Nida Farooqui Fatima Mir Dilsha Siddiqui Aneeta Hotwani Apsara Ali Nathwani Syed Faisal Mahmood Kamran Sadiq Hammad Afzal Kayani Saqib Ali Sheikh Sharaf Ali Shah Rashida Abbas Ferrand Syed Hani Abidi Source Type: research
Overexpression and purification of PreS region of hepatitis B virus antigenic surface protein adr subtype in Escherichia coli
This report deals with overexpression and purification of adr subtype of surface antigen that is more prevalent in Pakistan. PreS region, comprising 119 aa preS1 region plus a 55 aa preS2 region plus 11 aa from the N-terminal S region, was inserted in pET21a+ vector, cloned in E. coli DH5alpha cells and expressed in E. coli BL21 codon+ cells. The conditions for over expression were optimized using different concentrations of IPTG (0.01-5 mM), and incubating the cells at different temperatures (23-41 degrees C) for different durations (0-6 h). The cells were grown under the given optimized conditions (0.5 mM IPTG concentrat...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: Naaz Abbas Aftab Ahmad Abdul Rauf Shakoori Source Type: research
