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Value of Quantitative Collateral Scoring on CT Angiography in Patients with Acute Ischemic Stroke ADULT BRAIN
CONCLUSIONS: Automated quantitative collateral scoring in patients with acute ischemic stroke is a reliable and user-independent measure of the collateral capacity on baseline CTA and has the potential to augment the triage of patients with acute stroke for endovascular therapy.
Source: American Journal of Neuroradiology - June 13, 2018 Category: Radiology Authors: Boers, A. M. M., Sales Barros, R., Jansen, I. G. H., Berkhemer, O. A., Beenen, L. F. M., Menon, B. K., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Slump, C. H., Majoie, C. B. L. M., Marquering, H. A. Tags: ADULT BRAIN Source Type: research

Prediction of long-term recurrent ischemic stroke: the added value of non-contrast CT, CT perfusion, and CT angiography
ConclusionData from CT imaging significantly improved the discriminatory performance and reclassification in predicting ischemic stroke recurrence beyond a model incorporating clinical risk factors only.
Source: Neuroradiology - March 17, 2021 Category: Radiology Source Type: research

Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank
ConclusionThrombus composition is significantly associated with stroke etiology, with an increase in RBC and a decrease in F/P raising the odds for a non-cardioembolic cause. No difference between composition of cardioembolic thrombi and of undetermined origin was seen. This emphasizes the need for more extensive monitoring for arrhythmias and/or extended cardiac analysis in case of an undetermined origin.
Source: Neuroradiology - April 15, 2023 Category: Radiology Source Type: research

Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach ADULT BRAIN
CONCLUSIONS: Our study confirms that infarct location has an important impact on functional outcome of patients with stroke and should be considered in prediction models. After we adjusted for covariates, the left-hemispheric corticosubcortical fiber tracts seemed to be of higher functional importance compared with cortical lesions.
Source: American Journal of Neuroradiology - November 15, 2018 Category: Radiology Authors: Ernst, M., Boers, A. M. M., Forkert, N. D., Berkhemer, O. A., Roos, Y. B., Dippel, D. W. J., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Vettorazzi, E., Fiehler, J., Marquering, H. A., Majoie, C. B. L. M., Gellissen, S., on behalf of the M Tags: ADULT BRAIN Source Type: research

Balloon Guide Catheter in Endovascular Treatment for Acute Ischemic Stroke: Results from the MR CLEAN Registry
ConclusionsIn clinical practice, use of a BGC was associated with higher reperfusion grade and early improvement of neurologic deficits, but had no positive effect on long-term functional outcome.
Source: Journal of Vascular and Interventional Radiology - September 19, 2019 Category: Radiology Source Type: research

Unsupervised Deep Learning for Stroke Lesion Segmentation on Follow-up CT Based on Generative Adversarial Networks FUNCTIONAL
CONCLUSIONS: An unsupervised generative adversarial network can be used to obtain automated infarct lesion segmentations with a moderate Dice similarity coefficient and good volumetric correspondence.
Source: American Journal of Neuroradiology - August 8, 2022 Category: Radiology Authors: van Voorst, H., Konduri, P. R., van Poppel, L. M., van der Steen, W., van der Sluijs, P. M., Slot, E. M. H., Emmer, B. J., van Zwam, W. H., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Zaharchuk, G., Caan, M. W. A., Marquering, H. A., on behalf of the CONTR Tags: FUNCTIONAL Source Type: research

CT Scanning in Suspected Stroke or Head Trauma: Is it Worth Going the Extra Mile and Including the Chest to Screen for COVID-19 Infection? ADULT BRAIN
CONCLUSIONS: The sensitivity of additional chest CT is fairly high. However, a negative result does not exclude COVID-19. The positive predictive value is poor. Correlation of chest CT results with epidemiologic history and clinical presentation, along with real-time reverse transcriptase polymerase chain reaction, is needed for confirmation.
Source: American Journal of Neuroradiology - July 12, 2020 Category: Radiology Authors: Kwee, R. M., Krdzalic, J., Fasen, B. A. C. M., de Jaegere, T. M. H., for the COVID-19 CT Investigators South-East Netherlands (CISEN) Study Group Tags: ADULT BRAIN Source Type: research

Value of Thrombus CT Characteristics in Patients with Acute Ischemic Stroke ADULT BRAIN
CONCLUSIONS: In our study on patients with large-vessel occlusion of the anterior circulation, CT thrombus characteristics appear useful for predicting functional outcome. However, in our study cohort, the effect of intra-arterial treatment was independent of the thrombus CT characteristics. Therefore, no arguments were provided to select patients for intra-arterial treatment using thrombus CT characteristics.
Source: American Journal of Neuroradiology - September 8, 2017 Category: Radiology Authors: Borst, J., Berkhemer, O. A., Santos, E. M. M., Yoo, A. J., den Blanken, M., Roos, Y. B. W. E. M., van Bavel, E., van Zwam, W. H., van Oostenbrugge, R. J., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., Marquering, H. A., Majoie, C. B. L. M., on behal Tags: ADULT BRAIN Source Type: research

Accuracy of CT Angiography for Differentiating Pseudo-Occlusion from True Occlusion or High-Grade Stenosis of the Extracranial ICA in Acute Ischemic Stroke: A Retrospective MR CLEAN Substudy INTERVENTIONAL
CONCLUSIONS: On CTA, extracranial ICA pseudo-occlusions can be differentiated from true carotid occlusions.
Source: American Journal of Neuroradiology - May 15, 2018 Category: Radiology Authors: Kappelhof, M., Marquering, H. A., Berkhemer, O. A., Borst, J., van der Lugt, A., van Zwam, W. H., Vos, J. A., Lycklama a Nijeholt, G., Majoie, C. B. L. M., Emmer, B. J., on behalf of the MR CLEAN Investigators Tags: INTERVENTIONAL Source Type: research

Radiology workload in clinical implementation of thrombectomy for acute ischemic stroke: experience from The Netherlands
ConclusionOur study estimated the number of stroke patients undergoing CTA for suspected LVO and those eligible for thrombectomy in relation to the population. Numbers were essentially the same throughout the week, and during office and on-call hours. Our data can be used to make adequate staffing plans.
Source: Neuroradiology - April 4, 2020 Category: Radiology Source Type: research

Effect of Heparinized Flush Concentration on Safety and Efficacy During Endovascular Thrombectomy for Acute Ischemic Stroke: Results from the  MR CLEAN Registry
ConclusionEffect of heparin in flush fluids should not be ignored by clinicians or researchers as higher concentrations may be associated with higher rates of ICH. The observed variation in protocols regarding heparin concentrations between EVT centers should encourage further studies, ideally in a controlled way, resulting in recommendations on heparin use in flush fluids in future guidelines.
Source: CardioVascular and Interventional Radiology - January 3, 2021 Category: Radiology Source Type: research

Validation of automated Alberta Stroke Program Early CT Score (ASPECTS) software for detection of early ischemic changes on non-contrast brain CT scans
ConclusionThe performance of automated ASPECTS is comparable to expert readers and could support readers in the detection of early ischemic changes.
Source: Neuroradiology - March 17, 2021 Category: Radiology Source Type: research

Prevalence and vascular risk factors of basal ganglia calcifications in patients at risk for cerebrovascular disease
Conclusions In this study with patients suspected of acute ischemic stroke, basal ganglia calcifications were common and significantly associated with older age and lower BMI.
Source: Journal of Neuroradiology - April 27, 2019 Category: Radiology Source Type: research

Flow Patterns in Carotid Webs: A Patient-Based Computational Fluid Dynamics Study EXTRACRANIAL VASCULAR
CONCLUSIONS: Carotid webs are associated with increased recirculation zones and regional increased wall shear stress metrics that are associated with disturbed flow. These findings suggest that a carotid web might stimulate thrombus formation, which increases the risk of acute ischemic stroke.
Source: American Journal of Neuroradiology - April 10, 2019 Category: Radiology Authors: Compagne, K. C. J., Dilba, K., Postema, E. J., van Es, A. C. G. M., Emmer, B. J., Majoie, C. B. L. M., van Zwam, W. H., Dippel, D. W. J., Wentzel, J. J., van der Lugt, A., Gijsen, F. J. H., for the MR CLEAN investigators Tags: EXTRACRANIAL VASCULAR Source Type: research

Diagnostic reference levels and median doses for common clinical indications of CT: findings from an international registry
ConclusionsDRLs for CTDIvol and DLP for EUCLID clinical indications from diverse organizations were established and can contribute to dose optimization. These values were usually significantly higher in the US than in Europe.Key Points•Registry data were used to create benchmarks for 10 common indications for CT identified by the European Society of Radiology.•Observed US radiation doses were higher than European for 9 of 10 indications (except chronic sinusitis).•The presented diagnostic reference levels and median doses highlight potentially unnecessary variation in radiation dose.
Source: European Radiology - October 13, 2021 Category: Radiology Source Type: research

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