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Total 250 results found since Jan 2013.

Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort
In conclusion, this cohort describes the clinical, genetic and laboratory findings of 29 Dutch DADA2 patients. We describe the occurrence of HLH as a life-threatening disease complication and report a relatively high incidence of malignancies and mortality.
Source: Journal of Clinical Immunology - June 5, 2023 Category: Allergy & Immunology Source Type: research

Safety and technical efficacy of early minimally invasive endoscopy-guided surgery for intracerebral haemorrhage: the Dutch Intracerebral haemorrhage Surgery Trial pilot study
ConclusionsMinimally invasive endoscopy-guided surgery within 8 h after symptom onset for supratentorial ICH appears to be safe and can effectively reduce ICH volume. Randomised controlled trials are needed to determine whether this intervention also improves functional outcome.Trial registrationClinicaltrials.gov: NCT03608423, August 1st, 2018.
Source: Acta Neurochirurgica - May 30, 2023 Category: Neurosurgery Source Type: research

Prehospital stroke triage: a modeling study on the impact of triage tools in different regions
CONCLUSIONS: In this modeling study, we showed that prehospital triage reduced time to EVT without disproportionate IVT delay, compared to a drip-and-ship strategy. The effect of triage strategies and the associated overtriage varied between regions. Implementation of prehospital triage should therefore be considered on a regional level.PMID:37219931 | DOI:10.1080/10903127.2023.2215859
Source: Prehospital Emergency Care - May 23, 2023 Category: Endocrinology Authors: Martijne H C Duvekot Bjarty L Garcia Luuk Dekker Truc My Nguyen Ido R van den Wijngaard Karlijn F de Laat Els L L M de Schryver Loet M H Kloos Leo A M Aerden Stas A Zylicz Jan Bosch Eduard van Belle Erik W van Zwet Anouk D Rozeman Walid Moudrous Fr édér Source Type: research

Collateral status and recanalization after endovascular treatment for acute ischemic stroke
Conclusions Collateral status is not associated with the probability of successful recanalization after EVT and does not modify the association between successful recanalization and functional outcome.
Source: Journal of NeuroInterventional Surgery - May 16, 2023 Category: Neurosurgery Authors: Uniken Venema, S. M., Dankbaar, J. W., Wolff, L., van Es, A. C. G. M., Sprengers, M., van der Lugt, A., Dippel, D. W. J., van der Worp, H. B., on behalf of the MR CLEAN Registry investigators, Dippel, Lugt, Majoie, Roos, Oostenbrugge, Zwam, Boiten, Vos, J Tags: Ischemic stroke Source Type: research

Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank
ConclusionThrombus composition is significantly associated with stroke etiology, with an increase in RBC and a decrease in F/P raising the odds for a non-cardioembolic cause. No difference between composition of cardioembolic thrombi and of undetermined origin was seen. This emphasizes the need for more extensive monitoring for arrhythmias and/or extended cardiac analysis in case of an undetermined origin.
Source: Neuroradiology - April 15, 2023 Category: Radiology Source Type: research

International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe
Conclusion: Our findings show how the longitudinal outcome of patients with type 2 diabetes varies significantly across European countries even after accounting for the distribution of underlying risk factors.Kidney Blood Press Res 2023;48:165 –174
Source: Kidney and Blood Pressure Research - April 4, 2023 Category: Urology & Nephrology Source Type: research

Improving outcomes of AF ablation by integrated personalized lifestyle interventions: rationale and design of the prevention to improve outcomes of PVI (POP) trial
This study is a prospective, 1:1 randomized, single centre, investigator-initiated clinical trial in 150 patients with paroxysmal or persistent AF referred for a first pulmonary vein isolation (PVI). Prior to the ablation, patients in the intervention group receive a personalized risk factor treatment programme in a specialized, protocolized, nurse-led outpatient clinic. Patient education and durable lifestyle management is promoted with an e-health platform. Patients in the control group receive standard care by cardiologists before ablation. The primary endpoint is the number of hospitalizations for re-ablation and cardi...
Source: Clinical Research in Cardiology - March 31, 2023 Category: Cardiology Source Type: research