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Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis using Iron Oxide Particles and MRI.
CONCLUSIONS: These functional molecular MRI probes constitute a novel imaging tool for ex vivo characterization of atherosclerosis at a molecular level. Further development and translation into the clinical arena will facilitate more accurate risk stratification in carotid artery disease in the future. PMID: 24594295 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - March 1, 2014 Category: Surgery Authors: Chan JM, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Gibbs RG Tags: Eur J Vasc Endovasc Surg Source Type: research

Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis using Iron Oxide Particles and MRI
This study aims at visualizing and characterizing atherosclerosis using antibody-conjugated superparamagnetic iron oxide (SPIO) particles as an MRI probe to assess inflammation in human atherosclerotic plaques.Methods: Atherosclerotic plaques were collected from 20 consecutive patients (n = 10 from symptomatic patients, n = 10 from asymptomatic patients) undergoing carotid endarterectomy (CEA) for extracranial high-grade internal carotid artery (ICA) stenosis (>70% luminal narrowing). Inflammatory markers on human atherosclerotic plaques were detected and characterized by ex vivo magnetic resonance imaging (MRI) using...
Source: European Journal of Vascular and Endovascular Surgery - March 3, 2014 Category: Surgery Authors: J.M.S. Chan, C. Monaco, M. Wylezinska-Arridge, J.L. Tremoleda, R.G.J. Gibbs Tags: Carotid Disease Source Type: research

Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging
This study characterized inflammation in atherosclerosis using dual-targeted microparticles of iron oxide (DT-MPIO) as a magnetic resonance imaging (MRI) probe.
Source: Journal of Vascular Surgery - June 23, 2017 Category: Surgery Authors: Joyce M.S. Chan, Claudia Monaco, Marzena Wylezinska-Arridge, Jordi L. Tremoleda, Jennifer E. Cole, Michael Goddard, Maggie S.H. Cheung, Kishore K. Bhakoo, Richard G.J. Gibbs Tags: From bench to bedside Source Type: research

The Predictive Capacity of the Buffalo Concussion Treadmill Test After Sport-Related Concussion in Adolescents
Conclusion This study found that the ΔHR (HRt minus resting HR) correlated with duration of clinical recovery in participants who were prescribed relative rest or a placebo-stretching program but not for participants prescribed sub-threshold aerobic exercise. A ΔHR of ≤50 bpm on the BCTT was 73% sensitive and 78% specific for predicting delayed recovery in concussed adolescents prescribed the current standard of care (i.e., cognitive and physical rest). This has implications for planning team and school activities in adolescents who sustain SRC. Ethics Statement This study was carried out in acco...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research