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Evaluation of the diagnostic value of FliD, a Helicobacter pylori flagellar protein
Jpn J Infect Dis. 2022 Mar 31. doi: 10.7883/yoken.JJID.2021.795. Online ahead of print.ABSTRACTNovel immunodominant antigens are urgently required for diagnosis and vaccine of Helicobacter pylori(HP). FliD, an important colonization factor was cloned and expressed(rFliD) to evaluate the levels of specific-IgG, IgM and IgA antibodies in the serum of patients by ELISA. Rabbit anti-rFliD polyclonal antibody (pAb) was obtained by subcutaneous injections of rFliD. The rFliD-specific IFN-γ and IL-4 of peripheral blood mononuclear cells and CD4+ T cells from human were analyzed by enzyme-linked immunospot and flow cytometry. We ...
Source: Japanese Journal of Infectious Diseases - March 31, 2022 Category: Infectious Diseases Authors: Wei Luo Qian Wang Xiaofang Zhang Dongmei Gu Weifeng Zhang Chunhui Yuan Source Type: research

Trends in cervical cancer incidence and mortality of young and middle adults in Japan
This study aimed to examine the trends in cervical cancer incidence and mortality for young and middle adult women in Japan, by analyzing trends in 10-year interval age-groups. Cervical cancer incidence for young and middle adult females (ages 20 to 59 years) was obtained from high-quality population-based cancer registries in three prefectures from 1985 to 2015. National cancer mortality data was obtained from published vital statistics from 1985 to 2019. Trends in crude and age-standardized rates (ASR) were analyzed using Joinpoint regression. The cervical cancer incidence trend in 20 to 59 year old females combined sign...
Source: Cancer Control - March 7, 2022 Category: Cancer & Oncology Authors: Sayo Tanaka Matthew Palmer Kota Katanoda Source Type: research

The prevalence of COVID-19 vaccination and vaccine hesitancy in pregnant women: an internet-based cross-sectional study in Japan
CONCLUSIONS: COVID-19 vaccination is not widespread among pregnant women in Japan although many vaccines have been shown to be safe in pregnancy. Accurate information dissemination and boosting trust in the government may be important to address vaccine hesitancy among pregnant women.PMID:35095091 | DOI:10.2188/jea.JE20210458
Source: Cancer Control - January 31, 2022 Category: Cancer & Oncology Authors: Yoshihiko Hosokawa Sumiyo Okawa Ai Hori Naho Morisaki Yoko Takahashi Takeo Fujiwara Shoji F Nakayama Hiromi Hamada Toyomi Satoh Takahiro Tabuchi Source Type: research

Roche COVID-19 At-Home Test granted FDA Emergency Use Authorization to expand access to rapid self-testing solutions in the United States
Rapid test to support the American public ’s fight against the COVID-19 pandemic, with availability to purchase over-the-counter (OTC) at pharmacies and retailers nationwideThe COVID-19 At-Home Test uses a simple nasal swab sample to enable individuals to self-test at home and receive accurate, reliable and quick results in as few as 20 minutes for SARS-CoV-2 and all known variants of concern, including Omicron.EUA granted through Roche ’s participation in the National Institutes of Health (NIH) Rapid Acceleration of Diagnostics (RADx) Independent Test Assessment Program to bring rapid tests to the OTC marketBasel, 24 ...
Source: Roche Media News - December 24, 2021 Category: Pharmaceuticals Source Type: news

Factors of parental COVID-19 vaccine hesitancy: A cross sectional study in Japan
This study aimed to assess factors related to parental COVID-19 vaccine hesitancy. A nationwide internet-based cross-sectional study was conducted between May 25 and June 3, 2021 in Japan. The target population was parents of children aged 3-14 years who resided in Japan, and agreed to answer the online questionnaire. Parental COVID-19 vaccine hesitancy (their intention to vaccinate their child) and related factors were analyzed using logistic regression models. Interaction effects of gender of parents and their level of social relationship satisfaction related to parental vaccine hesitancy was tested using log likelihood ...
Source: Cancer Control - December 17, 2021 Category: Cancer & Oncology Authors: Sayaka Horiuchi Haruka Sakamoto Sarah K Abe Ryoji Shinohara Megumi Kushima Sanae Otawa Hideki Yui Yuka Akiyama Tadao Ooka Reiji Kojima Hiroshi Yokomichi Kunio Miyake Takashi Mizutani Zentaro Yamagata Source Type: research

Hepatitis B: Who should be treated?-managing patients with chronic hepatitis B during the immune-tolerant and immunoactive phases
World J Gastroenterol. 2021 Nov 21;27(43):7497-7508. doi: 10.3748/wjg.v27.i43.7497.ABSTRACTNew hepatitis B virus (HBV) infections are decreasing owing to improved antiviral therapy and increased HBV vaccination worldwide; however, the number of HBV infections remains a major cause of liver carcinogenesis. HBV triggers cytotoxic immunity to eliminate HBV-infected cells. Therefore, the HBV pathophysiology changes in persistently infected individuals depending on host immune responses and HBV DNA proliferation state. To prevent liver cirrhosis and carcinogenesis caused by HBV, it is important to treat HBV infection at an earl...
Source: World Journal of Gastroenterology : WJG - December 10, 2021 Category: Gastroenterology Authors: Miwa Kawanaka Ken Nishino Hirofumi Kawamoto Ken Haruma Source Type: research

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