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Drug: Estradiol
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Total 49 results found since Jan 2013.
Impairment of oocyte maturation as a mechanism of decreased fecundity in Japanese medaka (Oryzias latipes) exposed to the brominated flame retardant, 1,2,5,6-tetrabromocyclooctane (TBCO)
Aquat Toxicol. 2023 Sep 11;263:106695. doi: 10.1016/j.aquatox.2023.106695. Online ahead of print.ABSTRACTInhibition of oocyte maturation is an understudied mechanism by which chemical stressors can impair fecundity of female fishes. The primary objective of the present study was to develop an assay to assess oocyte maturation disruption by chemical stressors in Japanese medaka (Oryzias latipes). First, an in vitro assay to assess maturation inducing hormone (MIH)-stimulated oocyte maturation in zebrafish was validated for use with Japanese medaka. Next, using the brominated flame retardant, 1,2,5,6-tetrabromocyclooctane (T...
Source: Aquatic Toxicology - September 16, 2023 Category: Toxicology Authors: Yamin Raza Chloe Devoy Paul D Jones Jon A Doering Steve Wiseman Source Type: research
Development of matrix-based reference materials for 17 beta-estradiol by the recommended reference method of ID-LC-MS/MS
Anal Bioanal Chem. 2023 Jul 25. doi: 10.1007/s00216-023-04832-2. Online ahead of print.ABSTRACTWe developed and evaluated two-level, namely 2017011 and 2017012, serum-based reference materials (RMs) for 17 beta-estradiol (17 β-E2) by the reference method of isotope dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS) from the remaining serum samples after routine clinical tests, to help improve clinical routine testing and provide the traceability of results. This paper describes the development process of these RMs. The National Metrology Institute of Japan (NMIJ) certified reference material (CRM) 6004-...
Source: Analytical and Bioanalytical Chemistry - July 25, 2023 Category: Chemistry Authors: Haibiao Lin Dan Liu Li Deng Jun Yan Liqiao Han Min Zhan Pengwei Zhang Jianbing Wang Min He Qiaoxuan Zhang Xianzhang Huang Source Type: research
Tributyltin-binding protein type 1 (fish acid glycoprotein) is a potential gatekeeper of ethinylestradiol action in fish
Comp Biochem Physiol C Toxicol Pharmacol. 2023 May 17:109660. doi: 10.1016/j.cbpc.2023.109660. Online ahead of print.ABSTRACTTributyltin (TBT)-binding protein type 1 in Japanese medaka (Oryzias latipes) (O.latTBT-bp1) is a fish lipocalin implicated in TBT binding and detoxification. We purified recombinant O.latTBT-bp1 (rO.latTBT-bp1; ca. 30 kDa) by using a baculovirus expression system and His- and Strep-tag chromatography process. Then, we examined O.latTBT-bp1 binding to several endo/exogenous steroid hormones by means of competitive binding assay. The dissociation constants for the binding of rO.latTBT-bp1 to DAUDA and...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - May 19, 2023 Category: Biochemistry Authors: Hibiki Hakata Yuki Takai Jae Man Lee Takahiro Kusakabe Hina Satone Yohei Shimasaki Yuji Oshima Source Type: research
Predictive factors for efficacy of testosterone replacement therapy for late-onset hypogonadism in Japanese men: a preliminary report
This study was conducted to determine the predictors of TRT efficacy for LOH. Fifty-six patients who visited our Men's Health Clinic (Kawanishi City Medical Center, Kawanishi and Hyogo Medical University, Nishinomiya, Hyogo, Japan) between November 2003 and June 2021 with data available before and after TRT were enrolled. They were divided into responders (Group 1; n = 45, accounting for 80.4%) and nonresponders (Group 2; n = 11, accounting for 19.6%) based on the clinical response to TRT, including patient satisfaction. Factors noted before TRT included age, body mass index, aging males' symptoms score, sexual health inve...
Source: Asian Journal of Andrology - May 6, 2023 Category: Urology & Nephrology Authors: Nobuyuki Kondoh Yohei Kaizuka Seiji Nagasawa Yoshikazu Togo Shingo Yamamoto Source Type: research
