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Sex Difference of Radiation Response in Occupational and Accidental Exposure
Conclusion and Outlook This review summarizes the data from major human studies on the health risks of radiation exposure and shows that sex can potentially influence the prolonged response to radiation exposure (Figure 1 and Tables 1, 2). These data suggest that long-term radiosensitivity in females is higher than that in males who receive a comparable dose of radiation. Our analysis of the literature agrees with the conclusions of the recent report on the Biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences (NAS), United States (National Research Council, 2006). The B...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research

Intravenous Thrombolysis in Posterior Circulation Stroke
Conclusions: Up to date, no data about PCIS and IVT are available from RTCs. Based on limited results from retrospective clinical studies and case series, IVT is safer for use in PCIS than in ACIS. Patients with brainstem ischemia, vertebral artery occlusion, and absence of basilar or posterior cerebral artery occlusion could be considered for treatment with IVT even in borderline cases. Time to IVT in PCIS seems to be a less crucial factor than in ACIS. IVT for PCIS may be beneficial even after 4.5 h from symptom onset. Introduction History of Intravenous Thrombolysis—The Most Relevant Studies Intravenous...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

6-Bromoindirubin-3 ′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
In this study, we aimed to investigate the anti-aging effect, and molecular mechanism, of the novel anti-aging drug 6BIO on naturally aged mouse liver. Rapamycin, a well-known promising anti-aging drug that delays aging through mTOR-dependent autophagy (Zhou and Ye, 2018), was used as the positive control in the study. To our knowledge, this is the first study to demonstrate the effects of 6BIO treatment in models of natural aging. Our results indicated that 6BIO ameliorates the decline of liver function with age, including lipid metabolism disorder, and attenuates hepatocyte senescence in aged mice, as revealed by altera...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Prevalence of spasticity in patients suffering from ischemic stroke in the internal carotid artery territory - the results of interim analysis of the national registry SONAR (P4.313)
Conclusions:Spasticity was noted in 44.9 % patients with neurological deficit due to first-ever stroke in carotid territory during the first 10 days after stroke onset. Severe spasticity was rare.Study Supported by:This study was conducted on an academic basis and supported by the AZV of the Ministry of Health of the Czech Republic no. 15-31921A; Ministry of Health of the Czech Republic MH CZ – DRO (FNOL, 00098892)–2016 and by a grant from the Internal Grant Agency of Palacky University IGA UP LF-2016-017.Disclosure: Dr. Kanovsky has received research support from Merz. Dr. Dornák has nothing to disclose...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kaňovsky, P., Dorňak, T., Maria, J., Jech, R., Bareš, M., Dušek, L., Mužik, J., Hoskovcova, M., Konvalinkova, R., Srp, M., Řiha, M., Navratilova, D., Otruba, P. Tags: Neuroepidemiology: Cerebrovascular Disease II Source Type: research