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Common variants of ROCKs and the risk of hypertension, and stroke: Two case-control studies and a follow-up study in Chinese Han population
Publication date: March 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1864, Issue 3 Author(s): Song Yang, Yanping Zhao, Yuanrui Tian, Yanchun Chen, Xianghai Zhao, Ying Li, Hailong Zhao, Xiaotian Chen, Lijun Zhu, Zhengmei Fang, YingShui Yao, Zhibing Hu, Chong Shen The Rho kinases (ROCKs) are recognized as a critical regulator of vascular functions in cardiovascular disorders. It is crucial to illustrate the association of ROCKs genetic variation and hypertension and/or stroke events. Herein we aimed at investigating the association of ROCK1 and ROCK2 with hypertension and stroke in Ch...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - January 4, 2018 Category: Molecular Biology Source Type: research

Bibliometric analysis and visualized study of research on autophagy in ischemic stroke
Conclusion: This bibliometric analysis helps us reveal the current research hotspots in the research field of autophagy in ischemic stroke and guide future research directions. Subsequent trends in this special field are likely to identify and develop novel autophagy-targeted therapy strategies to effectively prevent and treat ischemic stroke.PMID:37731738 | PMC:PMC10507179 | DOI:10.3389/fphar.2023.1232114
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Jiefang Chen Gaijie Chen Xiaojing Xu Long Chen Jiewen Zhang Feng Liu Source Type: research

Serum tissue inhibitor of metalloproteinase-1 and risk of cognitive impairment after acute ischaemic stroke.
Abstract The expression of tissue inhibitor metalloproteinase-1 (TIMP-1) significantly increased after acute cerebral ischaemia and involved in neurodegeneration. The purpose was to prospectively investigate the relationship between serum TIMP-1 with post-stroke cognitive impairment. Our participants were from an ancillary study of China Antihypertensive Trial in Acute Ischemic Stroke. 598 ischaemic stroke patients from seven participating hospitals were included. Cognitive impairment was evaluated using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at 3 months. 316 (52.84%) or 384...
Source: J Cell Mol Med - May 19, 2020 Category: Molecular Biology Authors: Ge J, Li R, Yuan P, Che B, Bu X, Shao H, Xu T, Ju Z, Zhang J, Zhang Y, Zhong C Tags: J Cell Mol Med Source Type: research

Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke
J Cell Mol Med. 2021 Sep 12. doi: 10.1111/jcmm.16923. Online ahead of print.ABSTRACTOridonin, a natural diterpenoid compound extracted from a Chinese herb, has been proved to exert anti-oxidative stress effects in various disease models. The aim of the present study was to investigate the protective effects of oridonin on oxidative stress-induced endothelial injury in ischaemic stroke. We found oridonin repaired blood-brain barrier (BBB) integrity presented with upregulation of tight junction proteins (TJ proteins) expression, inhibited the infiltration of periphery inflammatory cells and neuroinflammation and thereby redu...
Source: J Cell Mol Med - September 13, 2021 Category: Molecular Biology Authors: Lei Li Shu-Qi Cheng Wei Guo Zhen-Yu Cai Yu-Qin Sun Xin-Xin Huang Jin Yang Juan Ji Ya-Yun Chen Yin-Feng Dong Hong Cheng Xiu-Lan Sun Source Type: research

Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: A large-scale genetic association study
The objective of this experiment was to observe the allele frequency and genotype distribution of some 9p21 SNPs in the Anhui Han population, and to study its relationship with the susceptibility to ischemic stroke. For this purpose, a collection of 992 patients with ischemic stroke confirmed and hospitalized in our hospital from October 2017 to October 2020 were used as the IS case group, and 951 normal people who had a healthy physical examination in the physical examination center of our hospital during the same period were selected as the control group. After informed consent, cubital venous blood of all subjects was c...
Source: Cellular and Molecular Biology - November 24, 2021 Category: Molecular Biology Authors: Rongyao Li Xinyue Zhang Wei Yin Yuzhuo Wang Ying Liu Source Type: research

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