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Specialty: Genetics & Stem Cells
Countries: China Health

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Total 41 results found since Jan 2013.

Effect of gene –gene and gene–environment interaction on the risk of first‐ever stroke and poststroke death
ConclusionsOur findings identified two novel genetic interactions ofVKORC1 andChr.9p21.3 and ofVEGFA andKDR for risk of stroke and subtypes as well as future stroke prognosis.
Source: Molecular Genetics & Genomic Medicine - July 9, 2019 Category: Genetics & Stem Cells Authors: Congrui Feng, Yunyun Yang, Shujun Yang, Xin Tu, Yibo Wang, Yiqing Song, Rutai Hui, Weili Zhang Tags: ORIGINAL ARTICLE Source Type: research

Effect of PITX2 genetic variants on the susceptibility to stroke in the Chinese Han population
CONCLUSIONS: This study indicated that there was a significant association between the PITX2 gene and stroke risk, and provided some data as far as possible to support the prevention of stroke.PMID:34990849 | DOI:10.1016/j.meegid.2021.105201
Source: Infection, Genetics and Evolution - January 6, 2022 Category: Genetics & Stem Cells Authors: Weiwei Zhao Xiuxia Hu Jie Hao Le Guo Wenjie Zhang Jianfeng Liu Tianbo Jin Dakuan Gao Jin Zhi Source Type: research

Chromosome 10q25 polymorphism is associated with susceptibility to large artery atherosclerotic stroke.
CONCLUSIONS: In the southeastern Chinese population, the rs11196288A > G polymorphism is associated with decreased risk of LAA stroke. PMID: 30580071 [PubMed - as supplied by publisher]
Source: Gene - December 20, 2018 Category: Genetics & Stem Cells Authors: Gu M, Wang M, Cai B, Cheng X, Li Z, Sun B, Wang F, Shi Y, Zhang Z, Liu X Tags: Gene Source Type: research

Association between K469E polymorphism of ICAM ‐1 gene and susceptibility of ischemic stroke: An updated meta‐analysis
ConclusionK469E polymorphism of ICAM ‐1 gene might be a risk factor for ischemic stroke in Caucasians, which suggested that K469E polymorphism might help in early identification of those at risk and help in primary prevention of ischemic stroke.
Source: Molecular Genetics & Genomic Medicine - June 2, 2019 Category: Genetics & Stem Cells Authors: Gaurav Nepal, Jayant Kumar Yadav, YuHui Kong Tags: ORIGINAL ARTICLE Source Type: research

Genetic variants in ALDH2 predict risk of ischemic stroke in a Chinese population.
CONCLUSIONS: Genetic polymorphisms in ALDH2 modified ischemic stroke risk and outcome in Chinese males, but not in females. PMID: 30077765 [PubMed - as supplied by publisher]
Source: Gene - August 2, 2018 Category: Genetics & Stem Cells Authors: Cheng X, Xu J, Gu M, Wang M, Sun B, Li Z, Ni G, Wang G, Weng Z, Shi Y, Zhang Z, Liu X Tags: Gene Source Type: research

Transcriptome Sequencing Unravels Potential Biomarkers at Different Stages of Cerebral Ischemic Stroke
This study assessed the characteristics of transcriptome changes at different stages of ischemic stroke using a mouse model of transient middle cerebral artery occlusion (tMCAO) and bioinformatics analyses. Cerebral cortex tissues from tMCAO mice at days 1, 3, 7, 14, and 28 were removed for RNA-Seq and small RNA-Seq library construction, sequencing, and bioinformatics analysis. We identified differentially expressed (DE) genes and miRNAs and revealed an association of the up-regulated or down-regulated DEmiRNAs with the correspondingly altered DEgene targets at each time point. In addition, different biological pathways we...
Source: Frontiers in Genetics - September 23, 2019 Category: Genetics & Stem Cells Source Type: research

Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population
Conclusion: Our results demonstrate that DNA methylation plays a crucial part in ischemic stroke. The methylation of these 7 genes may be potential diagnostic biomarker for ischemic stroke.
Source: Frontiers in Genetics - April 11, 2022 Category: Genetics & Stem Cells Source Type: research

Associations of CYP2C19 and F2R genetic polymorphisms with platelet reactivity in Chinese ischemic stroke patients receiving clopidogrel therapy
Conclusions Together, these results emphasized the necessity of genotype-directed antiplatelet therapy and facilitated to minimize adverse ischemic events.
Source: Pharmacogenetics and Genomics - May 13, 2022 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

EDNRA Gene rs1878406 Polymorphism is Associated With Susceptibility to Large Artery Atherosclerotic Stroke
Conclusion: The rs1878406 C > T polymorphism is associated with increased risk of LAA stroke in the Chinese Han population.
Source: Frontiers in Genetics - January 3, 2022 Category: Genetics & Stem Cells Source Type: research

Polymorphism in genes encoding two fatty acid binding proteins increases risk of ischemic stroke in a Chinese Han population
Conclusion: The GA genotype of FABP2 rs1799883, interactions between rs1799883, rs2241883 and smoking and alcohol consumption were associated with IS risk in Chinese Han populations.
Source: Frontiers in Genetics - April 6, 2023 Category: Genetics & Stem Cells Source Type: research

The Association Between Thymidylate Synthase Gene Polymorphisms and the Risk of Ischemic Stroke in Chinese Han Population
In conclusion: This study has shown that TS rs699517 and rs2790 were significantly related to ischemic stroke patients.PMID:37378701 | DOI:10.1007/s10528-023-10431-8
Source: Biochemical Genetics - June 28, 2023 Category: Genetics & Stem Cells Authors: Fuhua Yu Lei Shi Qianru Wang Xiaohui Xing Zhongchen Li Lei Hou Zhengshan Zhou Zengguang Wang Yilei Xiao Source Type: research

GSE140275 Expression profile and potential functions of circulating long noncoding RNAs in acute ischemic stroke in the Southern Chinese Han population
Conclusion: This study provides evidence of altered expression of lncRNAs and their potential functions in AIS. Our findings may facilitate pathological mechanistic studies of lncRNAs in AIS and provide potential diagnostic biomarkers and therapeutic targets for AIS.
Source: GEO: Gene Expression Omnibus - November 13, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Association between polymorphisms in ABO gene and stroke patients with small artery occlusion in southern Chinese Han population.
CONCLUSION: The resultsindicate that rs532436 polymorphism in ABO gene may have association with SAO in southern Chinese Han population. PMID: 33053422 [PubMed - as supplied by publisher]
Source: Gene - October 11, 2020 Category: Genetics & Stem Cells Authors: Jiang YY, Li JL, Liu LY, Zhou GQ, Mo DC, Jiang DD, Luo M Tags: Gene Source Type: research

Association between Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphism with the risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of 53 Studies
CONCLUSION: This meta-analysis suggests that ACE I/D polymorphism may lead to risk of HS and can be a potential biomarker for HS susceptibility especially in Asian population.PMID:33964377 | DOI:10.1016/j.gene.2021.145696
Source: Gene - May 8, 2021 Category: Genetics & Stem Cells Authors: Manabesh Nath Shubham Misra Pumanshi Talwar Deepti Vibha Achal Kumar Srivastava Kameshwar Prasad Pradeep Kumar Source Type: research