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Prognosis of Subtypes of Acute Large Artery Atherosclerotic Cerebral Infarction by Evaluation of Established Collateral Circulation
Background: The prognosis of acute ischemic stroke is related to collateral circulation, which is different with different pathogenesis. Objective: To explore the prognosis of acute large atherosclerotic (LAA) cerebral infarction with different pathogenesis by assessing the establishment of collateral circulation. Methods: 108 patients with acute LAA cerebral infarction in our hospital, who failed to thrombolytic or thrombectomy in the acute phase were selected and classified by Chinese ischemic stroke subclassification (CISS).
Source: Journal of Stroke and Cerebrovascular Diseases - August 20, 2020 Category: Neurology Authors: Xiaohong Gui, Liping Wang, Chenglong Wu, Hua Wang, Jianguo Kong Source Type: research

Nomogram for predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage in the Chinese population
The incidence of stroke is high worldwide1 and is the leading cause of death in China presently.2,3 Subarachnoid hemorrhage caused by ruptured intracranial aneurysm is a subtype of severe stroke that occurs suddenly in seemingly healthy individuals with generally poor prognosis.4 Surgical clipping and endovascular coiling are effective treatment modalities for patients with aneurysmal subarachnoid hemorrhage (aSAH). Delayed cerebral ischemia (DCI) is a complication of aSAH, occurring in up to 30% of patients,5 and is an important cause of disability and death, often leading to deterioration of patients ’ condition or quality of life.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Haonan Liu, Qian Xu, Aimin Li Source Type: research

Sex differences of ischemic stroke in young adults —A single-center Chinese cohort study
Stroke at a young age is a societal challenge with a rising incidence. Our aim was to investigate sex differences in risk factors, etiology, and diagnostic process of ischemic stroke in Chinese young adults.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Mingyu Tang, Ming Yao, Yicheng Zhu, Bin Peng, Lixin Zhou, Jun Ni Source Type: research

Is smoking a risk factor for bleeding in adult men with cerebral arteriovenous malformations? A single-center regression study from China
To assess whether smoking increases the risk of bleeding in patients with cerebral arteriovenous malformations (CAVM).
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Shuai Zhang, Chenguang Zhou, Dong Liu, Yongjun Piao, Fuqiang Zhang, Jie Hu, Zongqian Ma, Zhanyang Wei, Weisheng Zhu, Ming Lv Source Type: research

Chinese medicine Tongxinluo capsule protects against blood-brain barrier disruption after ischemic stroke by inhibiting the low-density lipoprotein receptor-related protein 1 pathway in mice
In this study, we explored whether TXL could downregulate LRP-1 expression and subsequently protect against BBB disruption after stroke using permanent middle cerebral artery occlusion (pMCAO) in mice.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Liping Chang, Li Hu, Cong Wei, Hui Zhang, Shen Liu Source Type: research

Decreased Serum Netrin-1 as a Predictor for Post-Stroke Depression in Chinese Patients with Acute Ischemic Stroke
Experimental studies demonstrated that netrin-1 (NT-1) is an important factor influencing the recovery after ischemic stroke. However, whether NT-1 levels were associated with the post-stroke depression (PSD) remains unclear. We aimed to evaluate the relationship between NT-1 levels and PSD at 3 months in patients with ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Zhuo Chen, Tianli Cao, Xingju Zhong, Yong Wu, Wei Fu, Chaoli Fan, Yu Jiang, Yan Zhu, Jie Peng, Ping Li, Jingyu Tan Source Type: research

Assessing executive function following the early stage of mild Ischemic stroke with three brief screening tests
Stroke, as the main disabling disease around the world, brings heavy economic and social burden to all countries, including China, an aging country.1 Post-stroke cognitive impairment (PSCI), one of the most “invisible disabilities”, is common among stroke survivors and can have a significant effect upon a patient's quality of life.2,3 Among stroke patients, the prevalence of PSCI is 81.4% and cognitive impairment in post-stroke patients manifests in various cognitive domains, with executive functio n being the most common.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Kai Shao, Wei Wang, Shang-Zun Guo, Fang-Ming Dong, Yi-Ming Yang, Zhong-Min Zhao, Yan-Li Jia, Jian-Hua Wang Source Type: research

Secular trends of stroke incidence and mortality in China, 1990 to 2016: The Global Burden of Disease Study 2016
The impact of socioeconomic developments on stroke incidence and mortality must be understood to target prevention strategies appropriately. We assessed the secular trends in stroke incidence and mortality in China based on data from the Global Burden of Disease Study 2016.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Yuan Wang, Lihui Zhou, Jian Guo, Yaogang Wang, Yu Yang, Qin Peng, Ying Gao, Wenli Lu Source Type: research

The association of rs2233679 in the PIN1 gene promoter with the risk of Coronary Artery Disease in Chinese female individuals
Cerebral vascular dysfunction is associated with various neurological disorders, which often share some common mechanisms with cardiovascular diseases especially Coronary Artery Disease (CAD).1 –6 Pin1 (encoded by the PIN1 gene) is a key enzyme in humans and is implicated in Alzheimer disease by suppressing amyloid–β deposition and tau aggregation.7–11 Recently, we hypothesized that Pin1 may cause cerebrovascular atherosclerosis and aggravate ischemia-related neurological disorders. 12 However, the relationship between the genetic polymorphisms of PIN1 and vascular atherosclerosis in humans is still not clear.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jing-Zhang Wang, Wen-Tao Du, Jing Bai, Shu-Zhen Cheng, Yu-Hua Zhang Source Type: research

The interplay between COVID 19 and non-communicable diseases
Since the coronavirus designated as COVID-19 emerged as a global pathogen in late 2019, there has been rapid spread across the globe. After originating in China, several high-income countries such as Italy, Spain, United States, and the United Kingdom have had high case prevalence and high levels of mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2020 Category: Neurology Authors: Seemant Chaturvedi, Philip Gorelick Source Type: research

Factors Associated with Pre-Hospital Delay and Intravenous Thrombolysis in China
Pre-hospital delay was a critical factor affecting stroke patients receiving intravenous thrombolytic therapy. The aim of this study was to explore the factors associated with pre-hospital delay and thrombolysis in China.
Source: Journal of Stroke and Cerebrovascular Diseases - May 15, 2020 Category: Neurology Authors: Yafang Zhu, Xia Zhang, Shoujiang You, Xiaowei Cao, Xuan Wang, Wenjie Gong, Yan Qin, Xiaojun Huang, Yongjun Cao, Rongfang Shi Source Type: research

Falling stroke rates during COVID-19 pandemic at a comprehensive stroke center
The novel human coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), began in Wuhan, China in December of 2019 and has led to a pandemic, accounting for more than 2.4 million worldwide infections and more than 160,000 deaths (as of April 20, 2020).1,2
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: J.E. Siegler, M.E. Heslin, L. Thau, A. Smith, T.G. Jovin Source Type: research

Risk factors and pathogenic microorganism characteristics for pneumonia in convalescent patients with stroke: A retrospective study of 380 patients from a rehabilitation hospital
Stroke significantly impacts public health and ranks among the leading causes of death and disabilities, resulting in enormous costs measured in both health care resources and lost productivity. It results primarily from embolus or thrombosis for ischemic stroke and hypertension for hemorrhagic stroke, respectively [1]. In 2016, there were 5.5 million deaths and 116.4 million disability-adjusted life-years (DALYs) owed to stroke [2]. As reported, the impact of stroke on the Chinese population is more severe compared to average global levels, and the prevalence of stroke continues to surpass that of ischemic heart disease [3 –4].
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Jia Xu, Zhiling Yang Source Type: research

Falling stroke rates during COVID-19 pandemic at a Comprehensive Stroke Center: Cover title: Falling stroke rates during COVID-19
The novel human coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), began in Wuhan, China in December of 2019 and has led to a pandemic, accounting for more than 2.4 million worldwide infections and more than 160,000 deaths (as of April 20, 2020).1,2
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: J.E. Siegler, M.E. Heslin, L. Thau, A. Smith, T.G. Jovin Source Type: research

Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights
An outbreak of an acute respiratory illness of unknown cause started in Wuhan, Hubei province, China on December 12, 2019.1,2 A new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in these patients. Subsequently, the identified acute respiratory illness was named coronavirus disease 2019 (COVID-19). Soon thereafter, the COVID-19 epidemic in China became a pandemic with a significant burden on healthcare and the world-wide economy. SARS-CoV-2 has been shown to be a distinct class of the beta coronaviruses (Beta-CoVs) with a 79.5% gene sequence homology to the severe ...
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2020 Category: Neurology Authors: Afshin A. Divani, Sasan Andalib, Mario Di Napoli, Simona Lattanzi, M. Shazam Hussain, Jos é Biller, Louise D. McCullough, M. Reza Azarpazhooh, Alina Seletska, Stephan A. Mayer, Michel Torbey Tags: Review Article Source Type: research

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