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Validation and Extension Study Exploring the Role of RNF213 p.R4810K in 2,877 Chinese Moyamoya Disease Patients
To validate, update, and extend the role of RNF213 p.R4810K (G>A) for predicting the phenotype of moyamoya disease (MMD) patients and explore the different effects on pediatric and adult groups.
Source: Journal of Stroke and Cerebrovascular Diseases - September 2, 2021 Category: Neurology Authors: Yue Wang, Zhengshan Zhang, Xiaotong Wang, Zhengxing Zou, Na Ta, Fangbin Hao, Yuetian Yang, Desheng Li, Man Liang, Cong Han, Xiangyang Bao, Lanxin Ou, Hui Wang, Zhibin Yang, Rimiao Yang, Fanxin Zeng, Mengke Shang, Fangfang Nie, Wanyang Liu, Lian Duan Source Type: research

A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study
The occurrence of stroke is driven by a combination of socio-demographic and cardio-metabolic factors whose contributions vary by geographical region and by race. Typically, clustering of risk factors in an individual is directly related to the probability of developing a stroke. There are several cardiovascular and stroke risk prediction models including the Framingham1 (USA), Prospective Cardiovascular Munster (PROCAM) study (USA)2, Global vascular risk score (GVRS) from the Northern Manhattan Study (USA)3, Reynolds risk score (USA)4, the China Multicenter Collaborative Study of Cardiovascular Epidemiology (MUCA) (China)...
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2021 Category: Neurology Authors: Onoja Akpa, Fred S. Sarfo, Mayowa Owolabi, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O. Osaigbovo, Godwin Ogbole, Hemant K. Tiwari, Carolyn Jenkins, Adekunle G. Fakunle, Samuel Olowookere, Ezinne O. Uvere, Source Type: research

10-O-(N N-Dimethylaminoethyl)-Ginkgolide B Methane-Sulfonate (XQ-1H) Ameliorates Cerebral Ischemia Via Suppressing Neuronal Apoptosis
This study was aimed to investigate the neuroprotective effect of XQ-1H in rats subjected to middle cerebral artery occlusion/reperfusion (MCAO/R) and the oxygen glucose deprivation/reoxygenation (OGD/R) induced neuronal apoptosis on pheochromocytoma (PC-12) cells.
Source: Journal of Stroke and Cerebrovascular Diseases - July 14, 2021 Category: Neurology Authors: Bayarmaa Khadankhuu, Yuxiang Fei, Xiang Li, Weirong Fang, Yunman Li Source Type: research

Effect of BMI on Central Arterial Reflected Wave Augmentation Index, Toe-Brachial Index, Brachial-Ankle Pulse Wave Velocity and Ankle-Brachial Index in Chinese Elderly Hypertensive Patients with Hemorrhagic Stroke
In recent years, with the aging of the Chinese population, the proportion of elderly hypertension has increased significantly. According to relevant epidemiological data, the prevalence of hypertension in the elderly in China is as high as 40 –60%.1 Hypertensive hemorrhagic stroke is one of the most serious complications of hypertension, and it usually occurs in the elderly. The main reason is that the wall of small arteries in the brain of hypertensive patients has glassy or fibrous degeneration, which reduces the elasticity of the bl ood vessel wall and causes local vasodilation.
Source: Journal of Stroke and Cerebrovascular Diseases - June 27, 2021 Category: Neurology Authors: Pengcheng Shuang, Jingzhi Yang, Chuangjun Li, Yingda Zang, Jie Ma, Fangyou Chen, Yongming Luo, Dongming Zhang Source Type: research

A Chinese CADASIL Family with a Novel Mutation on Exon 10 of Notch3 Gene
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which is caused by the Notch3 gene mutation, has its unique clinical and imaging characteristics. Here we present a Chinese family with a novel mutation on exon 10 of Notch3 gene.
Source: Journal of Stroke and Cerebrovascular Diseases - June 10, 2021 Category: Neurology Authors: Yuan Liu, Shicun Huang, Liqiang Yu, Tan Li, Shanshan Diao, Zhiguo Chen, Guoqing Zhou, Xihua Sheng, Yuan Xu, Qi Fang Source Type: research

Clinical and Genetic Risk Factors of Long-Term Outcomes after Encephaloduroarteriosynangiosis in Moyamoya Disease in China
This retrospective study was conducted to analyze the associations between ring finger protein 213 p.R4810K variant, clinical features and long-term outcomes in patients with moyamoya disease (MMD) after encephaloduroarteriosynangiosis treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2021 Category: Neurology Authors: Xiaotong Wang, Zhengshan Zhang, Yue Wang, Zhengxing Zou, Na Ta, Fangbin Hao, Mengke Shang, Desheng Li, Fanxin Zeng, Cong Han, Fangfang Nie, Xiangyang Bao, Yuetian Yang, Hui Wang, Man Liang, Rimiao Yang, Lanxin Ou, Lu Wen, Zhibin Yang, Wanyang Liu, Lian Du Source Type: research

Coronavirus Positive Patients Presenting with Stroke-Like Symptoms
Several studies from Wuhan, China have reported neurological manifestations in patients who tested positive for coronavirus disease 2019 (COVID-19). One study reported 214 COVID-19 positive patients, out of which 41.1% had severe infection. 5.7% of patients with severe infection had acute cerebrovascular disease1. Another study looked at 221 COVID-19 positive patients, out of which 5% had ischemic infarcts and 0.5% had cerebral hemorrhage2. A recent study from Mount Sinai Hospital in New York reported five cases of cerebral infarcts due to large vessel occlusion in patients who tested positive for COVID-19.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2021 Category: Neurology Authors: Shaista Alam, Robin N. Dharia, Elan Miller, Fred Rincon, Diana L. Tzeng, Rodney D. Bell Source Type: research

Changes in Characteristics, Treatment and Outcome in Patients with Hemorrhagic Stroke During COVID-19
The coronavirus disease 2019 (COVID-19) pandemic has had a comprehensive impact on healthcare services worldwide. We sought to determine whether COVID-19 affected the treatment and prognosis of hemorrhagic stroke in a regional medical center in mainland China.
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2020 Category: Neurology Authors: Yuqi Chen, Fan Xia, Yunke Li, Hao Li, Lu Ma, Xin Hu, Chao You Source Type: research

The Association Between Apolipoprotein E Gene Polymorphism and In-Stent Restenosis After Extracranial and Intracranial Artery Stenting
Stroke is one of the leading causes of disability and death worldwide. In China acute ischemic stroke (AIS) accounts for approximately 70% of all strokes. As an important cause of AIS, large artery atherosclerotic stroke (LAAS) is characterized by high morbidity, disability rate, recurrence rate and mortality.1 –3 The safety and efficacy of stenting in preventing recurrence of stroke have been demonstrated;4,5 however, in-stent restenosis (ISR) remains a major limitation of endovascular treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - November 19, 2020 Category: Neurology Authors: Zhoucheng Kang, Yuhong Cao, Li Li, Guangyun Zhang Source Type: research

Prognosis of Neurological Improvement in Inpatient Acute Ischemic Stroke Survivors: A Propensity Score Matching Analysis
Stroke has become a national concern in China. Early prediction of stroke benefits patients and aids medical professionals in clinical decision making and rehabilitation plans to improve successful outcomes. To identify prediction factors influencing short-term outcomes in patients with acute ischemic stroke (AIS).
Source: Journal of Stroke and Cerebrovascular Diseases - November 14, 2020 Category: Neurology Authors: Qian Wu, Ai-Jie Tang, Li Zeng, Shu-Zhen Niu, Mei-Mei Tian, Ai-Ping Jin, Hong-Yan Yang, Jing-Juan Chen, Zhu Xiao-ping, Yan Shi Source Type: research

A Novel Mutation Outside of the EGFr Encoding Exons of NOTCH3 Gene in a Chinese with CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vascular disease caused by the mutations of the NOTCH3 gene. The NOTCH3 gene consists of 33 exons. The pathogenic mutations of the NOTCH3 gene in CADASIL are located in 2 –24 exons coding for the 34 EGFr (epidermal growth factor-like repeat) domains. The classical clinical manifestations are recurrent TIA or ischaemic stroke, migraine, cognitive disorder and affective disorder.
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2020 Category: Neurology Authors: wan Wang, Zhixia Ren, yingying Shi, Jiewen Zhang Source Type: research

Feasibility of a Nurse-Trained, Family Member-Delivered Rehabilitation Model for Disabled Stroke Patients in Rural Chongqing, China
This study aimed to evaluate the feasibility of a novel nurse-trained, family member-delivered rehabilitation model for disabled stroke patients in rural southwest China.
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2020 Category: Neurology Authors: Kun Chu, Xiaoqing Bu, Zhenxing Sun, Yuan Wang, Wenqin Feng, Li Xiao, Fuyan Jiang, Xiaojun Tang Source Type: research

Stroke Systems of Care during the COVID-19 Epidemic in Kobe City
The novel coronavirus disease 2019  (COVID-19), first reported in Wuhan, China, in December 2019, spread worldwide in 2020. As of June 1, 2020, the estimated number of global cases and deaths has exceeded 6 million and 370,000, respectively.1 In Japan, the number of reported cases increased sharply in March 2020, with community tran smission presenting at the highest rate in urban areas, leading to a state of emergency being declared by the Japanese government on April 7. Subsequently, on April 9, the Japan Stroke Society and the Japanese Circulation Society issued a joint statement on the importance of maintaining high-q...
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2020 Category: Neurology Authors: Nobuyuki Ohara, Hirotoshi Imamura, Hidemitsu Adachi, Yoshie Hara, Kohkichi Hosoda, Hidehito Kimura, Kazuyuki Kuwayama, Takashi Mizowaki, Yasuhiko Motooka, Kazuya Nakashima, Narihide Shinoda, Takeshi Takamoto, Yasushi Ueno, Ikuya Yamaura, Chie Yanagihara, Source Type: research

Collaborative Care Model Based Telerehabilitation Exercise Training Program for Acute Stroke Patients in China: A Randomized Controlled Trial
Early rehabilitation has been proved very important for stroke patients. However, the effective model of transitioning from early in-hospital rehabilitation to discharge rehabilitation using the collaborative remote rehabilitation nursing model has not been thoroughly studied.
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2020 Category: Neurology Authors: Zhishui Wu, Jingjuan Xu, Chunxian Yue, Yi Li, Yongchun Liang Source Type: research

Clinical Features of CVT in Women and Effect on Subsequent Pregnancy: A Follow-Up Study in a Chinese National Comprehensive Hospital
Cerebral venous thrombosis (CVT) is a relatively rare subtype of ischemic cerebrovascular disease, accounting for only 0.5% –1.0% of all strokes1 and occurring more commonly in young women. The International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) reported that 78% of CVT patients were younger than 50 years old and 75% were female.2 This significant gender difference may be due to many gender-specific risk factors, such as pregnancy, puerperium, and oral contraceptives. In pregnancy and puerperium, changes in hemodynamics and sex hormone levels could cause a hypercoagulable state in the body.
Source: Journal of Stroke and Cerebrovascular Diseases - September 5, 2020 Category: Neurology Authors: Ya-Ting Wu, Li-Xin Zhou, Ming Yao, Jun Ni, Yi-Cheng Zhu, Li-Ying Cui, Bin Peng Source Type: research

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