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Drug: Temodar
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Total 29 results found since Jan 2013.
Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance
CONCLUSIONS: The direct intracranial infusion of shikonin has potential as a local therapy for patients with glioblastoma.PMID:37557011 | DOI:10.1016/j.biopha.2023.115296
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 9, 2023 Category: Drugs & Pharmacology Authors: Ryosuke Maeoka Yukiteru Ouji Tsutomu Nakazawa Ryosuke Matsuda Takayuki Morimoto Shohei Yokoyama Shuichi Yamada Fumihiko Nishimura Ichiro Nakagawa Young-Soo Park Masahide Yoshikawa Hiroyuki Nakase Source Type: research
Leucine-rich repeats containing 4 protein (LRRC4) in memory, psychoneurosis, and glioblastoma
Chin Med J (Engl). 2023 Feb 13. doi: 10.1097/CM9.0000000000002441. Online ahead of print.ABSTRACTLeucine-rich repeats containing 4 ( LRRC4 , also named Netrin-G ligand 2 [NGL-2]) is a member of the NetrinGs ligands (NGLs) family. As a gene with relatively high and specific expression in brain, it is a member of the leucine-rich repeat superfamily and has been proven to be a suppressor gene for gliomas, thus being involved in gliomagenesis. LRRC4 is the core of microRNA-dependent multi-phase regulatory loops that inhibit the proliferation and invasion of glioblastoma (GB) cells, including LRRC4/NGL2-activator protein 2 (AP2...
Source: Chinese Medical Journal - February 13, 2023 Category: General Medicine Authors: Kun Deng Minghua Wu Source Type: research
MicroRNAs, Key Regulators in Glioma Progression as Potential Therapeutic Targets for Chinese Medicine
Am J Chin Med. 2022 Sep 17:1-27. doi: 10.1142/S0192415X22500768. Online ahead of print.ABSTRACTGliomas are tumors of the primary central nervous system associated with poor prognosis and high mortality. The 5-year survival rate of patients with gliomas received surgery combined with chemotherapy or radiotherapy does not exceed 5%. Although temozolomide is commonly used in the treatment of gliomas, the development of resistance limits its use. MicroRNAs are non-coding RNAs involved in numerous processes of glioma cells, such as proliferation, migration and apoptosis. MicroRNAs regulate cell cycle, PI3K/AKT signal pathway, a...
Source: The American Journal of Chinese Medicine - September 19, 2022 Category: Complementary Medicine Authors: Huali Fan Xiaofang Xie Xi Kuang Junrong Du Fu Peng Source Type: research
