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Using LASSO regression to estimate the population-level impact of pneumococcal conjugate vaccines
Am J Epidemiol. 2023 Mar 17:kwad061. doi: 10.1093/aje/kwad061. Online ahead of print.ABSTRACTThe pneumococcal conjugate vaccines (PCVs) protect against diseases caused by Streptococcus pneumoniae, such as meningitis, bacteremia, and pneumonia. It is challenging to estimate their population-level impact due to the lack of a perfect control population and the subtleness of signals when the endpoint - like all-cause pneumonia - is non-specific. Here we present a new approach to estimate PCVs' impact - using LASSO regression to select variables in a synthetic control model to predict the counterfactual outcome for vaccine impa...
Source: Am J Epidemiol - March 19, 2023 Category: Epidemiology Authors: Anabelle Wong Sarah C Kramer Marco Piccininni Jessica L Rohmann Tobias Kurth Sylvie Escolano Ulrike Grittner Matthieu Domenech de Cell ès Source Type: research

Invasive meningococcal disease in Chile seven years after ACWY conjugate vaccine introduction
CONCLUSION: Overall-IMD, MenW cases and incidence declined since 2015 after the MCV-ACWY introduction, while MenB, MenC and MenY have been stable. MenW incidence declined in all age groups, including non-immunized infants and people >60 years. Further analysis and a longer period of observation are needed to have a more robust conclusion about this epidemiological trend. By 2019, CFR remains high.PMID:34996641 | DOI:10.1016/j.vaccine.2021.11.075
Source: Vaccine - January 8, 2022 Category: Allergy & Immunology Authors: R Villena M T Valenzuela M Bast ías M E Santolaya Source Type: research

Pneumococcal vaccine in patients with idiopathic juvenile arthritis in treatment with tumor necrosis factor inhibitors
CONCLUSIONS: The pneumococcal vaccine induces protective levels of serum antibodies in JIA patients undergoing TNFi treatment. The vaccination schedule and the lymphocyte count could influence the response capacity.PMID:34224229 | DOI:10.15586/aei.v49i4.203
Source: Allergologia et Immunopathologia - July 5, 2021 Category: Allergy & Immunology Authors: Javiera Berho Mar ía-Paulina Monsalvez Jorge Rojas Jaime Inostroza Arnoldo Quezada Source Type: research

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