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A multicenter trial of extracorporeal cardiac shock wave therapy for refractory angina pectoris: report of the highly advanced medical treatment in Japan
In this study, we further addressed the efficacy and safety of CSWT in a single-arm multicenter study approved as a highly advanced medical treatment by the Japanese Ministry of Health, Labour and Welfare. Fifty patients with refractory AP [mean age 70.9  ± 12.6 (SD) years, M/F 38/12] without the indications of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) were enrolled in 4 institutes in Japan. Ischemic myocardial regions in the left ventricle (LV) were identified by drug-induced stress myocardial perfusion imaging (MPI). Shock waves (200 shots/spot at 0.09 mJ/mm2) were applied t...
Source: Heart and Vessels - June 25, 2018 Category: Cardiology Source Type: research

Long-term Follow-up of the Trial of Routine Angioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI)
Conclusions Despite the short-term benefit and safety of an early invasive strategy in patients with STEMI receiving fibrinolysis, no statistically significant differences in MACE were observed over 7.8 years.
Source: Canadian Journal of Cardiology - May 26, 2018 Category: Cardiology Source Type: research

The Potential Effects of New Stent Platforms for Coronary Revascularization in Patients With Diabetes
Publication date: May 2018 Source:Canadian Journal of Cardiology, Volume 34, Issue 5 Author(s): Gustavo S. Guandalini, Sripal Bangalore Coronary artery disease in patients with diabetes mellitus (DM) is characterized by extensive atherosclerosis, longer lesions, and diffuse distal disease. Consequently, these patients have worse outcomes after coronary revascularization, regardless of the modality used. Traditionally, coronary artery bypass grafting (CABG) has been regarded as more effective than percutaneous coronary intervention (PCI) in patients with DM, likely because of more complete revascularization and protection ...
Source: Canadian Journal of Cardiology - May 4, 2018 Category: Cardiology Source Type: research

The potential impact of new stent platforms for coronary revascularization in diabetics
Publication date: Available online 1 March 2018 Source:Canadian Journal of Cardiology Author(s): Gustavo S. Guandalini, Sripal Bangalore Coronary artery disease in patients with diabetes mellitus (DM) is characterized by extensive atherosclerosis, longer lesions and diffuse distal disease. Consequently, these patients have worse outcomes following coronary revascularization, regardless of the modality employed. Traditionally, coronary artery bypass grafting (CABG) has been regarded as more effective than percutaneous coronary intervention (PCI) in patients with DM, owing likely to more complete revascularization and prote...
Source: Canadian Journal of Cardiology - March 2, 2018 Category: Cardiology Source Type: research

Long term Follow-up of the Trial of Routine ANgioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER AMI)
Conclusion Despite the short-term benefit and safety of an early invasive strategy in STEMI patients receiving fibrinolysis, no statistically-significant differences in MACE were observed over 7.8 years.
Source: Canadian Journal of Cardiology - February 10, 2018 Category: Cardiology Source Type: research

Associations between Complex PCI and Prasugrel or Clopidogrel use in Patients with Acute Coronary Syndromes undergoing PCI: From the PROMETHEUS Study
Conclusions Despite the use of contemporary techniques, ACS patients undergoing complex PCI had significantly higher rates of 1-year MACE. Adjusted magnitude of treatment effects with prasugrel versus clopidogrel were consistent in complex and non-complex PCI without evidence of interaction. Teaser In this analysis from the PROMETHEUS ACS registry (n = 19,914), complex PCI (PCI of left main/ bifurcation/ moderate-severely calcified lesion/ stent length ≥30mm) was associated with greater risk of 1-year MACE (death, myocardial infarction, stroke or unplanned revascularization; HR 1.29 [1.20-1.39]). Treatment effects with p...
Source: Canadian Journal of Cardiology - December 27, 2017 Category: Cardiology Source Type: research

Temporal changes in treatments and outcomes after acute myocardial infarction among cancer survivors and patients without cancer, 1995 to 2013
CONCLUSIONSAmong CS and NCP with AMI in Ontario, similar improvements in mortality and receipt of treatments were observed between 1995 and 2013. However, compared with NCP, CS had a higher risk of mortality and heart failure. Cancer 2017. © 2017 American Cancer Society.
Source: Cancer - December 6, 2017 Category: Cancer & Oncology Authors: Inna Y. Gong, Andrew T. Yan, Dennis T. Ko, Craig C. Earle, Winson Y. Cheung, Stuart Peacock, Marlous Hall, Chris P. Gale, Kelvin K. W. Chan Tags: Original Article Source Type: research

Antiplatelet Effect of Different Loading Doses of Ticagrelor in Patients With Non –ST-Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: The APELOT Trial
Conclusions Doubling the ticagrelor LD achieved faster onset and greater platelet inhibition without an increase in adverse events in patients with NSTE-ACS undergoing PCI.
Source: Canadian Journal of Cardiology - December 3, 2017 Category: Cardiology Source Type: research

Antiplatelet Effect of Different Loading Doses of Ticagrelor in Non-ST-Elevation Acute Coronary Syndrome Patients Undergoing PCI: The APELOT Trial
Conclusions Doubling the ticagrelor loading dose achieved faster onset and greater platelet inhibition without an increase in adverse events in patients with NSTE-ACS undergoing PCI.
Source: Canadian Journal of Cardiology - September 13, 2017 Category: Cardiology Source Type: research

Contemporary Atrial Fibrillation Management: A Comparison of the Current AHA/ACC/HRS, CCS, and ESC Guidelines
Publication date: August 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 8 Author(s): Jason G. Andrade, Laurent Macle, Stanley Nattel, Atul Verma, John Cairns In this article we compare and contrast the current recommendations, and highlight the important differences, in the American College of Cardiology/American Heart Association/Heart Rhythm Society, European Society of Cardiology, and Canadian Cardiovascular Society atrial fibrillation (AF) guidelines. Although many of the recommendations of the various societies are similar, there are important differences in the methodologies underlying their developmen...
Source: Canadian Journal of Cardiology - July 26, 2017 Category: Cardiology Source Type: research

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