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Effect of intravenous thrombolysis with alteplase on clinical efficacy, inflammatory factors, and neurological function in patients with acute cerebral infarction
This study aimed to explore the effect of intravenous thrombolysis with alteplase on clinical efficacy, inflammatory factors, and neurological function in patients with acute cerebral infarction. A total of 120 patients with acute cerebral infarction were divided into two groups by the random number table method, with 60 patients in each group: observation group (intravenous thrombolysis with alteplase) and control group (intravenous thrombolysis with batroxobin). The clinical efficacy after a 14-day treatment was observed. Serum C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), CD62p, GMP-...
Source: Brazilian Journal of Medical and Biological Research - March 17, 2021 Category: Research Authors: Jinhua Wang Xia Fang Dongliang Wang Yuan Xiao Source Type: research

Efficacy of repetitive transcranial magnetic stimulation for post-stroke depression: a systematic review and meta-analysis of randomized clinical trials.
In conclusion, from the current evidence in this study, rTMS could be an effective treatment for patients with PSD. Further clinical studies with larger sample sizes and clearer subgroup definitions are needed to confirm these outcomes. PMID: 33470386 [PubMed - in process]
Source: Brazilian Journal of Medical and Biological Research - January 21, 2021 Category: Research Tags: Braz J Med Biol Res Source Type: research

Association between serum non-high-density lipoprotein cholesterol and cognitive dysfunction after acute ischemic stroke: a cross-sectional study.
This study aimed to explore the association between serum non-high-density lipoprotein cholesterol (non-HDL-C) and cognitive dysfunction risk in patients with acute ischemic stroke (AIS). This cross-sectional study enrolled 583 AIS patients. Biochemical markers and lipid profile were collected after admission. AIS patients were classified into high group (non-HDL-C ≥3.4 mM) and normal group (non-HDL-C <3.4 mM). Mini-Mental State Examination scale (MMSE), Montreal Cognitive Assessment scale (MoCA), Activities of Daily Living (ADL) scale, Neuropsychiatric Inventory (NPI), and Hamilton Depression scale 21 version (HAMD-2...
Source: Brazilian Journal of Medical and Biological Research - November 5, 2020 Category: Research Tags: Braz J Med Biol Res Source Type: research

Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil.
Authors: Vidal KS, Suemoto CK, Moreno AB, Duncan B, Schmidt MI, Maestri M, Barreto SM, Lotufo PA, Bertola L, Bensenor IM, Brunoni AR Abstract Recent evidence suggests that glaucoma and Alzheimer's disease are neurodegenerative diseases sharing common pathophysiological and etiological features, although findings are inconclusive. We sought to investigate whether self-reported glaucoma patients without dementia present poorer cognitive performance, an issue that has been less investigated. We employed cross-sectional data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) and included participants â...
Source: Brazilian Journal of Medical and Biological Research - November 5, 2020 Category: Research Tags: Braz J Med Biol Res Source Type: research

Association of circulating long non-coding RNA MALAT1 in diagnosis, disease surveillance, and prognosis of acute ischemic stroke.
Authors: Ren H, Wu F, Liu B, Song Z, Qu D Abstract We aimed to investigate the association of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lnc-MALAT1) with acute ischemic stroke (AIS), and its association with disease severity, inflammation, and recurrence-free survival (RFS) in AIS patients. One hundred and twenty AIS patients and 120 controls were recruited. Venous blood samples from AIS patients (within 24 h after symptoms onset) and controls (at entry to study) were collected to detect plasma lnc-MALAT1 expression by real-time quantitative polymerase chain reaction. AIS severity w...
Source: Brazilian Journal of Medical and Biological Research - October 29, 2020 Category: Research Tags: Braz J Med Biol Res Source Type: research

A newly designed intensive caregiver education program reduces cognitive impairment, anxiety, and depression in patients with acute ischemic stroke.
In conclusion, ICEP effectively reduced cognitive impairment, anxiety, and depression in AIS patients. PMID: 31483000 [PubMed - in process]
Source: Brazilian Journal of Medical and Biological Research - September 5, 2019 Category: Research Tags: Braz J Med Biol Res Source Type: research

Translation and Cross-Cultural Adaptation of SATIS-Stroke for Use in Brazil: A Satisfaction Measure of Activities and Participation in Stroke Survivors.
Conclusion: The final version of the SATIS-Stroke scale in Brazilian Portuguese proved to be adequate and reliable for use on the Brazilian population. Further studies are underway to give continuity to the validation process and analyze the others measurement properties of the scale in the Brazilian population. PMID: 30906780 [PubMed - in process]
Source: Biomed Res - March 26, 2019 Category: Research Authors: Pereira GS, Silva SM, Júlio CE, Thonnard JL, Bouffioulx E, Corrêa JCF, Corrêa FI Tags: Biomed Res Int Source Type: research

Evaluation of platelet activity by multiple electrode impedance aggregometry in acute coronary syndromes: pilot study in a Brazilian tertiary-care public hospital.
This study suggested that the evaluation of PA in ACS using MEA may identify non-responders to ASA. Larger studies are necessary to define, in a public health scenario, the value of MEA in the management of ACS. PMID: 30652826 [PubMed - in process]
Source: Braz J Med Biol Res - January 10, 2019 Category: Research Authors: De Lorenzo A, Dutra M, Mattos MA, Rey HCV, Tibirica E Tags: Braz J Med Biol Res Source Type: research

The burden of stroke in Brazil in 2016: an analysis of the Global Burden of Disease study findings
To analyze the epidemiological stroke data of Brazil according to the Global Burden of Disease (GBD) study in 2016 and secondary data from the GBD database.
Source: BMC Research Notes - October 16, 2018 Category: Research Authors: Nathalia Matos de Santana, Francisco Winter dos Santos Figueiredo, Diego Monteiro de Melo Lucena, Fernando Mayo Soares, Fernando Adami, Luciana de Carvalho P ádua Cardoso and João Antonio Correa Tags: Research note Source Type: research

Efficacy, acceptability, and tolerability of antidepressant treatments for patients with post-stroke depression: a network meta-analysis.
Authors: Qin B, Chen H, Gao W, Zhao LB, Zhao MJ, Qin HX, Chen W, Chen L, Yang MX Abstract The aim of this study was to investigate the efficacy, acceptability, and tolerability of antidepressants in treating post-stroke depression (PSD) by performing a network meta-analysis of randomized controlled trials of the current literature. Eligible studies were retrieved from online databases, and relevant data were extracted. The primary outcome was efficacy as measured by the mean change in overall depressive symptoms. Secondary outcomes included discontinued treatment for any reason and specifically due to adverse event...
Source: Brazilian Journal of Medical and Biological Research - May 10, 2018 Category: Research Tags: Braz J Med Biol Res Source Type: research

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