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Specialty: Cardiology
Procedure: Transplants
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Total 1589 results found since Jan 2013.
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research
Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition
In this study, we have revealed a novel mechanism underlying the suppressive effects of L-flow on EC inflammation, migration, proliferation, apoptosis, and fibrotic changes through promoting CHK1-induced SENP2 S344 phosphorylation. The phospho-site mutation SENP2 S344A responds to L-flow through a distinct mechanism, which involves the upregulation of both mesenchymal and EC marker genes.PMID:37711550 | PMC:PMC10499395 | DOI:10.3389/fcvm.2023.1187490
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Minh T H Nguyen Masaki Imanishi Shengyu Li Khanh Chau Priyanka Banerjee Loka Reddy Velatooru Kyung Ae Ko Venkata S K Samanthapudi Young J Gi Ling-Ling Lee Rei J Abe Elena McBeath Anita Deswal Steven H Lin Nicolas L Palaskas Robert Dantzer Keigi Fujiwara M Source Type: research
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies < em > SPP1 < /em > < sup > + < /sup > Macrophage Subpopulation as a Target for Alleviating Fibrosis
CONCLUSIONS: SPP1+ macrophages accumulated in the PVAT surrounding atherosclerotic coronary arteries, and they promoted the migration and proliferation of fibroadipogenic progenitor cells via OPN-CD44/integrin interaction and thus aggravated the fibrosis of coronary PVAT, which was positively correlated to the coronary stenosis burden. Therefore, SPP1+ macrophages in coronary PVAT may participate in the progression of coronary atherosclerosis.PMID:37706320 | DOI:10.1161/ATVBAHA.123.319828
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Mengxia Fu Songren Shu Zhiming Peng Xiaorui Liu Xiao Chen Zhiwei Zeng Yicheng Yang Hao Cui Ruojin Zhao Xiaohu Wang Leilei Du Min Wu Wei Feng Jiangping Song Source Type: research
Dual action of macrophage miR-204 confines cyclosporine A-induced atherosclerosis
Conclusion and implications Macrophage miR-204 ameliorates CsA-induced atherosclerosis, suggesting that miR-204 may be a potential target for the prevention and treatment of CsA-related atherosclerotic side effects.PMID:37702564 | DOI:10.1111/bph.16240
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Jia-Hui Su Yu Hong Cong-Cong Han Jie Yu Xin Guan Ya-Mei Zhu Cheng Wang Ming-Ming Ma Rui-Ping Pang Jing-Song Ou Jia-Guo Zhou Zi-Yi Zhang Tao Ban Si-Jia Liang Source Type: research
