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Total 205 results found since Jan 2013.
Microcystin-LR induced transgenerational effects of thyroid disruption in zebra fish offspring by endoplasmic reticulum stress-mediated thyroglobulin accumulation and apoptosis
Environ Pollut. 2023 Jan 20:121117. doi: 10.1016/j.envpol.2023.121117. Online ahead of print.ABSTRACTMC-LR can interfere with thyroid function in fish, but the underlying mechanism is still unclear. Current study focuses to study the intergenerational inheritance of MC-LR-induced thyroid toxicity in zebrafish and in rat thyroid cells. In vivo experiments, adult female zebrafish (F0) were exposed to MC-LR (0, 5, and 25 μg/L) for 90 days and mated with male zebrafish without MC-LR exposure to generate F1 generation. F1 embryos were allowed to develop normally to 7 days post-fertilization (dpf) in clear water. In the F0 gen...
Source: Environmental Pollution - January 23, 2023 Category: Environmental Health Authors: Weirong Si Mengjie Zhao Huimin Che Zaiwei Wu Yuchun Xiao Xinxin Xie Jiayao Duan Tong Shen Dexiang Xu Sujuan Zhao Source Type: research
Exploring the molecular mechanisms underlie the endoplasmic reticulum stress-mediated methylmercury-induced neuronal developmental damage
Ecotoxicol Environ Saf. 2022 Sep 21;245:114099. doi: 10.1016/j.ecoenv.2022.114099. Online ahead of print.ABSTRACTMethylmercury (MeHg) is a ubiquitous environmental pollutant, which can cross the placenta and blood brain barrier, thus affecting fetal growth and development. Although previous studies have demonstrated that MeHg induces endoplasmic reticulum (ER) stress in rat cerebral cortex and primary neurons, the role of ER stress in MeHg-induced neurodevelopmental toxicity remains unclear. Here, we used ICR pregnant mice and hippocampal neurons cells (HT22 cells) to investigate the molecular mechanism by which MeHg expos...
Source: Ecotoxicology and Environmental Safety - September 24, 2022 Category: Environmental Health Authors: Jingjing Pan Xiaoyang Li Haihui Liu Chen Wang Si Xu Bin Xu Yu Deng Tianyao Yang Wei Liu Source Type: research
Transcriptome analysis identifies IL24 as an autophagy modulator in PM2.5 caused lung dysfunction
CONCLUSIONS: In summary, we discovered a potential relationship between IL24 and autophagy during PM2.5 exposure. IL24 might be a novel potential biomarker or therapeutic target in PM2.5 caused lung dysfunction through regulation of autophagy.PMID:36049333 | DOI:10.1016/j.ecoenv.2022.114039
Source: Ecotoxicology and Environmental Safety - September 1, 2022 Category: Environmental Health Authors: Yao Liu Xiang He Jiliu Liu Lei Zhang Anying Xiong Junyi Wang Shengbin Liu Manling Jiang Li Luo Ying Xiong Guoping Li Source Type: research
Mechanism underlying the targeted regulation of the SOD1 3'UTR by the AUF1/Dicer1/miR-155/SOD1 pathway in sodium arsenite-induced liver injury
This study provides an important research basis for further understanding the factors underlying arsenic-induced liver injury to improve the prevention and control strategies for arsenism.PMID:35998476 | DOI:10.1016/j.ecoenv.2022.113990
Source: Ecotoxicology and Environmental Safety - August 23, 2022 Category: Environmental Health Authors: Dingnian Bi Mingyang Shi Dan Zheng Qian Hu Hongling Wang Liuyu Peng Didong Lou Aihua Zhang Yong Hu Source Type: research
IJERPH, Vol. 19, Pages 8118: The Potential Key Role of the NRF2/NQO1 Pathway in the Health Effects of Arsenic Pollution on SCC
In this study, we found that arsenite can promote the transformation of immortalized human keratinocyte cells (HaCaT) from the G0/G1 phase to S phase and demonstrated malignant phenotypes. This phenomenon is accompanied by obviously elevated levels of NRF2, NQO1, Cyclin E, and Cyclin-dependent kinase 2 (CDK2). Silencing the NRF2 expression with small interfering RNA (siRNA) in arsenite-transformed (T-HaCaT) cells was shown to reverse the malignant phenotype. Furthermore, the siRNA silencing of NQO1 significantly decreased the levels of the cyclin E-CDK2 complex, inhibiting the G0/G1 to S phase cell cycle progression and tr...
Source: International Journal of Environmental Research and Public Health - July 1, 2022 Category: Environmental Health Authors: Qianlei Yang Rui Yan Yuemei Mo Haixuan Xia Hanyi Deng Xiaojuan Wang Chunchun Li Koichi Kato Hengdong Zhang Tingxu Jin Jie Zhang Yan An Tags: Article Source Type: research
IJERPH, Vol. 19, Pages 6775: Inhibition of HIF-1 & alpha; Attenuates Silica-Induced Pulmonary Fibrosis
Conclusion: Inhibition of HIF-1α reduced α-SMA, decreased COL1A1 expression, and attenuated the degree of PF in C57BL/6N mice. Therefore, HIF-1α may be a new target for the treatment of silica-induced PF.
Source: International Journal of Environmental Research and Public Health - June 1, 2022 Category: Environmental Health Authors: Xiao Xu Yiping Li Zhuoya Niu Jiarui Xia Kai Dai Chen Wang Wu Yao Yonghua Guo Xuedan Deng Jing He Meng Deng Huifang Si Changfu Hao Tags: Article Source Type: research
HMGB1-NLRP3-P2X7R pathway participates in PM < sub > 2.5 < /sub > -induced hippocampal neuron impairment by regulating microglia activation
In this study, we focused on the role of HMGB1-NLRP3-P2X7R pathway which mediated the microglia activation in hippocampal neurons impairment induced by PM2.5 using a co-culture model of microglia and hippocampal neurons. We found that PM2.5 resulted in activated microglia and HMGB1-NLRP3 inflammatory pathway, and elevated proinflammatory cytokines of IL-18 and IL-1β in a dose-dependent manner. Notably, we next utilized previously reported pharmacological inhibitors or siRNA for HMGB1 and found that they significantly inhibited the activation of downstream NLRP3 and MAPK pathways derived from PM2.5 exposure, and down-regul...
Source: Ecotoxicology and Environmental Safety - May 23, 2022 Category: Environmental Health Authors: Chong Liu Yingjie She Jia Huang Yongping Liu Wanwei Li Can Zhang Tianliang Zhang Li Yu Source Type: research
Repression of autophagy leads to acrosome biogenesis disruption caused by a sub-chronic oral administration of polystyrene nanoparticles
In this study, we aimed to determine the effects of polystyrene nanoplastics (PS-NPs) (50 nm) on sperm quality, with a focus on the acrosome defects. After 35 days of intragastric administration, sperm quality was decreased and testicular structures were impaired in mice exposed to PS-NPs in both the medium (1.0 mg/kg) and high dose (10 mg/kg) groups. No significant changes were observed in the low dose (0.2 mg/kg) group. Meanwhile, acrosome parameters including acrosome integrity and acrosome reaction were decreased after the administration of PS-NPs. These findings were consistent with the disruption of acrosome biogenes...
Source: Environment International - April 5, 2022 Category: Environmental Health Authors: Lixiao Zhou Ziying Yu Yinyin Xia Shuqun Cheng Jieying Gao Wei Sun Xuejun Jiang Jun Zhang Lejiao Mao Xia Qin Zhen Zou Jingfu Qiu Chengzhi Chen Source Type: research
