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Total 101 results found since Jan 2013.

Protein kinase a‐dependent pSer675‐β‐catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis
Conclusion: These data show that in fibrocystin‐defective cholangiocytes, cAMP/PKA signaling stimulates pSer675‐phosphorylation of β‐catenin and Rac‐1 activity. In the presence of activated Rac‐1, pSer675‐β‐catenin is translocated to the nucleus, becomes transcriptionally active, and is responsible for increased motility of Pkhd1del4/del4 cholangiocytes. β‐Catenin‐dependent changes in cell motility may be central to the pathogenesis of the disease and represent a potential therapeutic target. (Hepatology 2013)
Source: Hepatology - September 30, 2013 Category: Internal Medicine Authors: Carlo Spirli, Luigi Locatelli, Carola M. Morell, Romina Fiorotto, Stuart D. Morton, Massimiliano Cadamuro, Luca Fabris, Mario Strazzabosco Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXR{gamma} activation
Tumor metastasis and lack of NKG2D ligand (NKG2DL) expression are associated with poor prognosis in patients with colon cancer. Here, we found that spironolactone (SPIR), an FDA-approved diuretic drug with a long-term safety profile, can up-regulate NKG2DL expression in multiple colon cancer cell lines by activating the ATM–Chk2-mediated checkpoint pathway, which in turn enhances tumor elimination by natural killer cells. SPIR can also up-regulate the expression of metastasis-suppressor genes TIMP2 and TIMP3, thereby reducing tumor cell invasiveness. Although SPIR is an aldosterone antagonist, its antitumor effects a...
Source: The Journal of Experimental Medicine - November 18, 2013 Category: Internal Medicine Authors: Leung, W.-H., Vong, Q. P., Lin, W., Janke, L., Chen, T., Leung, W. Tags: Articles Source Type: research

RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma
Conclusion: DUSP21 plays an important role in sustaining HCC cell proliferation and may thus act as a potential therapeutic target in HCC treatment. (Hepatology 2013;)
Source: Hepatology - December 18, 2013 Category: Internal Medicine Authors: Qing Deng, Kun‐Yu Li, Hui Chen, Ji‐Hong Dai, Yang‐Yang Zhai, Qun Wang, Niu Li, Yu‐Ping Wang, Ze‐Guang Han Tags: Hepatobiliary Malignancies Source Type: research

Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticum
Conclusions: Our study shows that we cannot simply extrapolate knowledge on cell signalling in vascular soft tissue calcification to a multisystem ectopic mineralisation disease as PXE. Contrary, we demonstrate a specific set of perturbed signalling pathways in PXE patients and the knock-out mouse model. Based on our findings and previously reported data, we propose a preliminary cell model of ECM calcification in PXE.
Source: Orphanet Journal of Rare Diseases - April 29, 2014 Category: Internal Medicine Authors: Mohammad HosenPaul CouckeOlivier Le SauxAnne De PaepeOlivier Vanakker Source Type: research

Livin is associated with the invasive and oncogenic phenotypes of human hepatocellular carcinoma cells
ConclusionThese results suggest that Livin is associated with invasive and oncogenic phenotypes of human HCC cells.
Source: Hepatology Research - July 22, 2014 Category: Internal Medicine Authors: Sung‐Bum Cho, Wan‐Sik Lee, Young‐Lan Park, Nuri Kim, Hyung‐Hoon Oh, Mi‐Young Kim, Chan‐Young Oak, Cho‐Yun Chung, Hyung‐Chul Park, Jong‐Sun Kim, Dae‐Seong Myung, Sang‐Hoon Kim, Kyung‐Hwa Lee, Sung‐Kyu Choi, Young‐Eun Joo Tags: Original Article Source Type: research

Role ofTranscription Factor CCAAT/Enhancer Binding Protein Alphain Human Fetal LiverCell Typesin vitro
ConclusionsWe demonstrated that the effects of C/EBPα are specific for the different human fetal liver cell types, using an advanced three‐dimensional perfusion bioreactor as a humanin vivo‐like model.
Source: Hepatology Research - September 5, 2014 Category: Internal Medicine Authors: Jörg C. Gerlach, Patrick Over, Hubert G. Foka, Morris E. Turner, Robert L. Thompson, Bruno Gridelli, Eva Schmelzer Tags: Original Article Source Type: research

Shp/Npas2 axis in regulating the oscillation of liver lipid metabolism
Conclusion: Shp and Npas2 crosstalk is essential to maintain hepatic lipid homeostasis. (Hepatology 2014)
Source: Hepatology - September 12, 2014 Category: Internal Medicine Authors: Sang Min Lee, Yuxia Zhang, Hiroyuki Tsuchiya, Rana Smalling, Anton M. Jetten, Li Wang Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Role of transcription factor CCAAT/enhancer‐binding protein alpha in human fetal liver cell types in vitro
ConclusionWe demonstrated that the effects of C/EBPα are specific for the different human fetal liver cell types, using an advanced 3‐D perfusion bioreactor as a human in vivo‐like model.
Source: Hepatology Research - October 9, 2014 Category: Internal Medicine Authors: Jörg C. Gerlach, Patrick Over, Hubert G. Foka, Morris E. Turner, Robert L. Thompson, Bruno Gridelli, Eva Schmelzer Tags: Original Article Source Type: research

Liver X receptors balance lipid stores in hepatic stellate cells via Rab18, a retinoid responsive lipid droplet protein
Conclusion: Retinoid and cholesterol metabolism are linked in stellate cells by the LD associated protein, Rab18. Retinoid overload helps explain the pro‐fibrotic phenotype of Lxrαβ‐/‐ mice and we establish a pivotal role for Rab18 GTPase activity and membrane insertion in wild‐type stellate cell activation. Interference with Rab18 may have significant therapeutic benefit in ameliorating liver fibrosis. This article is protected by copyright. All rights reserved.
Source: Hepatology - December 6, 2014 Category: Internal Medicine Authors: Fiona O'Mahony, Kevin Wroblewski, Sheila M. O'Byrne, Hongfeng Jiang, Kara Clerkin, Jihane Benhammou, William S. Blaner, Simon W. Beaven Tags: Liver Biology and Pathobiology Source Type: research

MiR‐486 regulates metastasis and chemosensitivity in hepatocellular carcinoma by targeting CLDN10 and CITRON
ConclusionsOur data indicated that miR‐486 may function as a novel tumor suppressor in HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - February 5, 2015 Category: Internal Medicine Authors: Huiyan Sun, Chunping Cui, Fengjun Xiao, Hua Wang, Jun Xu, Xuefeng Shi, Yuefeng Yang, Qunwei Zhang, Xiaofei Zheng, Xiaoming Yang, Chutse Wu, Lisheng Wang Tags: Original Article Source Type: research

Increased duodenal iron absorption through upregulation of DMT1 due to enhancement of IRP1 activity in patients with NASH
Conclusion: In spite of elevation of serum hepcidin, iron absorption from the gastrointestinal tract increased through upregulation of DMT1, via IRP1 activation by humoral factor(s) in the sera of patients with NASH. This article is protected by copyright. All rights reserved.
Source: Hepatology - March 7, 2015 Category: Internal Medicine Authors: Toshifumi Hoki, Koji Miyanishi, Shingo Tanaka, Kohichi Takada, Yutaka Kawano, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Activation of Sphingosine Kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance
Conclusion: Sphk2 is transcriptionally upregulated by acute ER stress via activation of ATF4 and improves perturbed hepatic glucose and fatty acid metabolism. This article is protected by copyright. All rights reserved.
Source: Hepatology - March 22, 2015 Category: Internal Medicine Authors: Su‐Yeon Lee, In‐Kyung Hong, Bo‐Rahm Kim, Soon‐Mi Shim, Jae Sung Lee, Hui‐Young Lee, Cheol Soo Choi, Bo‐Kyung Kim, Tae‐Sik Park Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Trefoil Factor 3 as a Novel Biomarker to Distinguish Between Adenocarcinoma and Squamous Cell Carcinoma
In conclusion, TFF3 is preferentially expressed in adenocarcinoma and may function as an additional biomarker for distinguishing adenocarcinoma from squamous cell carcinoma.
Source: Medicine - May 1, 2015 Category: Internal Medicine Tags: Article: Observational Study Source Type: research

Specific hepatic delivery of procollagen α1(I) siRNA in lipid‐like nanoparticles resolves liver fibrosis
Conclusion: The data reported in the present study extensively show that LNP‐siCol1a1 specifically reduce total hepatic collagen content without detectable side effects, potentially qualifying as a therapy for fibrotic liver diseases. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 10, 2015 Category: Internal Medicine Authors: Carolina Jiménez Calvente, Alfica Sehgal, Yury Popov, Yong Ook Kim, Victor Zevallos, Ugur Sahin, Mustafa Diken, Detlef Schuppan Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research

Mineralocorticoid receptor suppresses cancer progression and Warburg effect by modulating miR‐338‐3p‐PKLR axis in hepatocellular carcinoma
Conclusion: The present study reveals a novel role of MR in HCC development by modulating miR‐338‐3p‐PKLR axis with an ability to suppress the Warburg effect. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 1, 2015 Category: Internal Medicine Authors: Huizhen Nie, Jun Li, Xiao‐Mei Yang, Qing‐Zhen Cao, Ming‐Xuan Feng, Feng Xue, Lin Wei, Wenxin Qin, Jianren Gu, Qiang Xia, Zhi‐Gang Zhang Tags: Hepatobiliary Malignancies Source Type: research