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Procedure: Transplants

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Terminally ill man from Maryland, 58, is living with a PIG'S HEART - after becoming second patient ever to get pioneering transplant surgery
This week, Lawrence Faucette, 58, received a transplanted pig heart at the University of Maryland Medical Center after being deemed ineligible for a human heart transplant due to a condition.
Source: the Mail online | Health - September 22, 2023 Category: Consumer Health News Source Type: news

Doctors Transplant Pig Heart Into Dying Man
Surgeons with the University of Maryland Medical Center were able to successfully transplant a pig’s heart into 58-year-old Lawrence Faucette on Wednesday, who was facing death with end-stage heart disease, the doctors announced Friday—marking just the second time this procedure, which doctors…#lawrencefaucette #bartleygriffith #marylanduniversity #davidbennett #annfaucette
Source: Reuters: Health - September 22, 2023 Category: Consumer Health News Source Type: news

Genetically Modified Pig ’s Heart Is Transplanted Into a Second Patient
The first patient to receive such an organ died after two months. “At least now I have hope,” the second recipient said before the surgery.
Source: NYT Health - September 22, 2023 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: your-feed-science Kidneys Genetic Engineering Pigs Heart Immune System Transplants Surgery and Surgeons University of Maryland Medical Center Source Type: news

Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Clinical Cancer Research - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research

Correction: Liver Transplantation After Hepatic Artery Infusion Pump Therapy: Single-Center Experience and Technical Considerations
Ann Surg Oncol. 2023 Sep 22. doi: 10.1245/s10434-023-14351-0. Online ahead of print.NO ABSTRACTPMID:37737969 | DOI:10.1245/s10434-023-14351-0
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Angela L Hill Darren R Cullinan Ola Ahmed Neeta Vachharajani Meranda D Scherer Franklin Olumba Adeel S Khan William C Chapman Majella B Doyle Source Type: research

EGR1 Promotes Ovarian Hyperstimulation Syndrome Through Upregulation of SOX9 Expression
This study aimed to investigate the function and mechanism of EGR1 involved in OHSS progression. RNA-sequencing was used to identify differentially expressed genes. In vitro OHSS cell model was induced by treating KGN cells with human chorionic gonadotropin (hCG). In vivo OHSS model was established in mice. The expression levels of EGR1, SOX1, and VEGF were determined by Quantitative Real-Time polymerase chain reaction (qRT-PCR), Western blot, immunofluorescence staining, and immunochemistry assay. The content of VEGF in the culture medium of human granulosa-like tumor cell line (KGN) cells was accessed by the ELISA assay....
Source: Cell Transplantation - September 22, 2023 Category: Cytology Authors: Huihui Wang Weijia Chen Yinan Huang Yuan Sun Yuanhua Liu Yuanchao Zhu Zongxuan Lu Source Type: research

Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4  + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research

Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research

Building the Evidence for Exercise in Solid Organ Transplant: How Far Have We Moved the Needle?
Physiother Can. 2023 Sep 19;75(3):209-211. doi: 10.3138/ptc-2022-0111. eCollection 2023 Sep.NO ABSTRACTPMID:37736416 | PMC:PMC10510535 | DOI:10.3138/ptc-2022-0111
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Sunita Mathur Tania Janaudis-Ferreira Manoela de Paula Ferreira Nicholas Bourgeois Tom Blydt-Hansen Tracy Fuller Robin Deliva Lorraine Hamiwka Source Type: research

La collecte de donn ées probantes sur l’exercice en cas de transplantation d’organe plein : à quel point avons-nous progressé?
Physiother Can. 2023 Sep 19;75(3):212-214. doi: 10.3138/ptc-2022-0111-fr. eCollection 2023 Sep.NO ABSTRACTPMID:37736412 | PMC:PMC10510543 | DOI:10.3138/ptc-2022-0111-fr
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Sunita Mathur Tania Janaudis-Ferreira Manoela de Paula Ferreira Nicholas Bourgeois Tom Blydt-Hansen Tracy Fuller Robin Deliva Lorraine Hamiwka Source Type: research

Regenerative Surgery: Is This an Independent Field of Health Sciences or Only a Semantic Exercise?
AbstractPurpose of ReviewThis manuscript aims at contextualizing the termregenerative surgery, whose recent introduction in the medical jargon has generated some confusion on both its significance and interplay with its synonymousregenerative medicine.Recent FindingsThe manuscript will illustrate the worldwide experience relative to the development ofregenerative surgery–related technologies, as they may be applied and be of interest to transplant medicine. Only few centers have invested in these technologies, the most relevant of which is cell on scaffold seeding technologies whereby cells, ideally isolated from the pat...
Source: Current Transplantation Reports - September 22, 2023 Category: Transplant Surgery Source Type: research

Against abandoning the dead donor rule: reply to Smith
Smith argues that death caused by transplant surgery will not harm permanently unconscious patients, because they will not suffer a setback to their interests in the context of donation. Therefore, so the argument goes, the dead donor rule can be abandoned, because requiring a death declaration before procurement does not protect any relevant interest from being thwarted. Smith contends that a virtue of his argument is that it avoids the controversies over defining and determining death. I argue that it does not and explain why no change in policy is justified.
Source: Journal of Medical Ethics - September 22, 2023 Category: Medical Ethics Authors: Omelianchuk, A. Tags: Response Source Type: research

Ethics briefings
What’s on the horizon? The Nuffield Council on Bioethics (NCOB) is delighted to pick up the mantel of the Ethics briefings. For readers less familiar with the NCOB’s work, we are a leading independent policy and research centre, and the foremost bioethics body in the UK. We identify, analyse and advise on ethical issues in biomedicine and health so that decisions in these areas benefit people and society.1 Established in 1991, the NCOB has tackled a wide range of bioethics and medical ethics issues over its thirty-two years, including issues relating to the beginning and end of life, health and society, data an...
Source: Journal of Medical Ethics - September 22, 2023 Category: Medical Ethics Authors: Mussell, R., Michaux, N., Gray, M. Tags: Ethics briefing Source Type: research

News at a glance: Diphtheria vaccine shortage, prisoner release, and iNaturalist ’s growth
CONSERVATION Popular biodiversity app to expand The nonprofit that runs iNaturalist, a popular app and website for identifying species, has received a $10 million grant to expand. The funding from the Gordon and Betty Moore Foundation, announced last week, will allow iNaturalist—whose website is one of the largest generators of crowd-sourced species-occurrence data—to add users, technology, and observations to inform conservation. iNaturalist hopes to grow in nature-rich parts of the world, such as Asia and South America, which have fewer users uploading data. Since iNaturalist’s founding in 2008, the ...
Source: Science of Aging Knowledge Environment - September 21, 2023 Category: Geriatrics Source Type: research