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A Broad Safety Assessment of the Recombinant Herpes Zoster Vaccine
Am J Epidemiol. 2022 Feb 12:kwac030. doi: 10.1093/aje/kwac030. Online ahead of print.ABSTRACTThe recombinant herpes zoster vaccine (RZV), approved as a 2-dose series in the U.S. in October 2017, has proven highly effective and generally safe. However, a small risk of Guillain-Barré syndrome (GBS) after vaccination was identified post-approval, and questions remain about other possible adverse events. This data-mining study assessed RZV safety in the U.S. using the self-controlled tree-temporal scan statistic, scanning data on thousands of diagnoses recorded during follow-up to detect any statistically unusual temporal clu...
Source: Herpes - February 13, 2022 Category: Infectious Diseases Authors: W Katherine Yih Martin Kulldorff Inna Dashevsky Judith C Maro Source Type: research

Canadian Immunization Guide: "Anaphylaxis and other acute reactions following vaccination" chapter update
CONCLUSION: The updated CIG chapter provides healthcare providers with further clarity in recognizing and managing anaphylaxis in community settings. The updated intramuscular epinephrine dosage table will aid in optimal epinephrine administration, while the revised guidance against the use of diphenhydramine hydrochloride will prevent its unnecessary stockpiling in preparation for potential mass vaccination clinics related to the coronavirus disease 2019 pandemic.PMID:33447159 | PMC:PMC7799880 | DOI:10.14745/ccdr.v46i1112a04
Source: Can Commun Dis Rep - January 15, 2021 Category: Infectious Diseases Authors: Natalie Dayneka Christina Jensen Kyla Hildebrand Source Type: research

Canadian Immunization Guide: "Anaphylaxis and other acute reactions following vaccination" chapter update.
Conclusion: The updated CIG chapter provides healthcare providers with further clarity in recognizing and managing anaphylaxis in community settings. The updated intramuscular epinephrine dosage table will aid in optimal epinephrine administration, while the revised guidance against the use of diphenhydramine hydrochloride will prevent its unnecessary stockpiling in preparation for potential mass vaccination clinics related to the coronavirus disease 2019 pandemic. PMID: 33447159 [PubMed]
Source: Can Commun Dis Rep - November 5, 2020 Category: Infectious Diseases Authors: Dayneka N, Jensen C, Hildebrand K Tags: Can Commun Dis Rep Source Type: research

NIAID dcientists create 3D structure of 1918 influenza virus-like particles
(NIH/National Institute of Allergy and Infectious Diseases) Virus-like particles (VLPs) are protein-based structures that mimic viruses and bind to antibodies. Because VLPs aren't infectious, they show promise as vaccine platforms for many viral diseases, including influenza. Since details about influenza VLPs are scant, a team of researchers developed a 3D model based on the 1918 H1 pandemic influenza virus. The research, conducted by NIAID scientists, could benefit VLP vaccine projects, targeting a range of viruses from HIV to Ebola and SARS coronavirus.
Source: EurekAlert! - Infectious and Emerging Diseases - July 11, 2018 Category: Infectious Diseases Source Type: news

NIH-funded researchers find signs TB can persist in lungs despite treatment
(NIH/National Institute of Allergy and Infectious Diseases) It has been known that the microbe that causes TB, Mycobacterium tuberculosis, can persist in the lungs even after patient tissue samples test negative for the bacteria. In new research appearing in Nature Medicine, intramural researchers at the NIAID its grantees found through the use of positron emission tomography/computerized tomography scanning that TB lesions can remain in the lungs long after treatment with antibiotics has been completed.
Source: EurekAlert! - Infectious and Emerging Diseases - September 6, 2016 Category: Infectious Diseases Source Type: news

Imaging techniques reliably predict treatment outcomes for TB patients
(NIH/National Institute of Allergy and Infectious Diseases) Two medical imaging techniques, called positron emission tomography and computed tomography, could be used in combination as a biomarker to predict the effectiveness of antibiotic drug regimens being tested to treat tuberculosis patients, according to researchers at NIAID, part of NIH. With multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis on the rise worldwide, new biomarkers are needed to determine whether a particular TB drug regimen is effective.
Source: EurekAlert! - Infectious and Emerging Diseases - December 4, 2014 Category: Infectious Diseases Source Type: news