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Ecchymotic Purpura of the Breast Revealing a Locally Advanced Breast Cancer: An Exceptional Presentation of a Carcinomatous Mastitis
A 79-year-old woman was treated at our department for a neoplasm of the left breast. It was discovered following the spontaneous appearance of a localized ecchymotic lesion of the breast. The only clinical sign was this purpura, with no notion of trauma. The lesion was homogeneous, oval, and measuring 4 × 5 cm, and it was stable for 2 months. The patient had no history of thrombocytopenia and no known allergy. The physical examination was not very helpful and did not find any palpable breast lesion besides a 1-cm left axillary lymphadenopathy. Breast screening revealed a solid, poorly delineated s tructure of 11 mm. Biops...
Source: Case Reports in Oncology - May 31, 2021 Category: Cancer & Oncology Source Type: research

Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for TP53 Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia
Discussion This case demonstrates successful cure of pre-B-ALL complicating XLA by alloSCT with restoration of B-cell development and functional antibody response. We are aware of only one previous case of pre-B-ALL in an XLA patient (21), which suggests that human BTK deficiency in itself does not predispose to pre-B-ALL. However, there are data to suggest that BTK may act as a tumor suppressor, and BTK deficiency may predispose to tumor development following a “second hit.” Mice with a genetic deficiency in Slp65, a gene encoding an adaptor protein that functions together with BTK, have a block in proge...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Rifamycin induced leukocytoclastic vasculitis. A rare side-effect of anti-tuberculous chemotherapy
We describe a case of leucocytoclastic vasculitis (LCV) caused by rifamycins.A 53 year old female presented with cough, night sweats and upper lobe nodules. Bronchial-alveolar lavage confirmed fully sensitive mycobacterium tuberculosis (TB).She commenced treatment with rifampicin, isoniazid, ethambutol and pyrizinazmide. At 4 weeks she developed an extensive purpuric rash, malaise and joint aches. There was no evidence of other infections or connective tissue disorders on extensive screening. Her inflammatory markers were elevated. A punch biopsy of her shin demonstrated leukocytoclastic vasculitis of the superficial dermi...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Ewence, A., Dodd, J., Tewari, A., Akhras, V., Aul, R. Tags: 10.2 Tuberculosis Source Type: research

Vasculitis after snorting cocaine contaminated with levamisole
Lawrence et al. Allergy Rhinol (Providence) 2014Copyright policy — open-access 3.5 out of 5 stars Cocaine-induced ecchymotic rash. Voore NK. Cleve Clin J Med 2016 Apr;3:252-253. Full Text Since at least 2010, a large percentage of cocaine samples seized in the United States has contained levamisole, a veterinary anti-worm medication. Levamisole had previously used in humans as an anti-helminthic and also in some chemotherapy regimens. It was withdrawn from the U.S. market in 1999 because of its association with agranulocytosis and vasculitis. It is apparently added to cocaine because it increases catecholamine release, ...
Source: The Poison Review - April 7, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cocaine levamisole vasculitis Source Type: news

Answers to Dermatophile
Answers From the questions on page 185. Answer to question 1 B—Langerhans cell histiocytosis (LCH): Abnormal clonal proliferation of histiocytes, resembling Langerhans cells, and its accumulation in different tissues and organs. LCH exhibits heterogeneous clinical pictures and evolution—it varies from the isolated cutaneous lesion with spontaneous resolution to severe cases involving the liver, spleen, lung and haematopoietic system.1 The most common skin lesion is similar to seborrhoeic dermatitis, but exhibits petechiae and purpura, and affects the scalp, eyebrows, ears and intertriginous areas.2 Seborrhoeic-...
Source: Archives of Disease in Childhood - Education and Practice - July 17, 2015 Category: Pediatrics Authors: Carvalho, V. O., Robl, R., Uber, M., Abagge, K. T., Marinoni, L. P., Presa, J. G. L. Tags: Oncology, Surgery, Immunology (including allergy), Drugs: infectious diseases, Child health, Pathology, Radiology, Interstitial lung disease, Dermatology, Surgical diagnostic tests, Clinical diagnostic tests, Drugs: endocrine system Dermatophile Source Type: research