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Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis
Conclusion Via a HPLC system and a BATMAN-TCM platform, for the first time we performed detailed HPLC fingerprint analysis and network pharmacology studies of QP ointment. By in-depth animal and molecular analysis, we identified a number of chronic dermatitis-associated Th1/2 cytokines, itch mediators, and cellular signaling pathways in the skin, DRG and serum for QP to treat the inflammation and chronic itch associated with ACD. Our data clearly suggested, upon stimulation, cytokines and itch-related mediators are released from the skin and neuronal tissues, and QP could effectively work on both the skin and sensory neur...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
AbstractFor centuries, itch was categorized as a submodality of pain. Recent research over the last decade has led to the realization that itch is in fact a separate and distinct, albeit closely related, sensation. Chronic itch is a common complaint and has numerous etiologies. Various receptors (TRPA1, TRPV1, PAR2, gastrin-releasing peptide receptor (GRPR), Mas-related G proteins), secreted molecules (histamine, nerve growth factor (NGF), substance P (SP), proteases), and cytokines/chemokines (thymic stromal lymphopoietin (TSLP), IL-2, IL-4, IL-13, and IL-31) are implicated as mediators of chronic pruritus. While much rem...
Source: Clinical Reviews in Allergy and Immunology - November 24, 2016 Category: Allergy & Immunology Source Type: research

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

No difference in pain, swelling or function with NSAIDs compared with paracetamol for soft tissue injury
Commentary on: Jones P, Dalziel SR, Lamdin R, et al. Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. Cochrane Database Syst Rev 2015;7:CD007789. Implications for practice and research Paracetamol may be the first choice of treatment for soft tissue injuries because of less adverse events and similar efficacy as non-steroidal anti-inflammatory drugs (NSAIDs). Additional randomised controlled trials (RCTs) are required to determine if there is a difference in return to function or adverse effects between non-selective and COX-2 selective NSAIDs versus paracetamol. F...
Source: Evidence-Based Nursing - December 15, 2015 Category: Nursing Authors: van den Bekerom, M. P. J. Tags: Pain management, Immunology (including allergy), Pain (neurology), Pain (palliative care), Pain (anaesthesia), Complementary medicine, Drugs: musculoskeletal and joint diseases, Trauma, Injury Source Type: research