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Ketogenic Diet as a Treatment for Super-Refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome
Conclusions: The characteristic EEG pattern in the acute phase promoted timely diagnosis of FIRES. Our data suggest that KD may be a safe and promising therapy for FIRES with SRSE, and that early initiation of KD produces a favorable prognosis. Therefore, KD should be applied earlier in the course of FIRES. Intravenous KD can be an effective alternative route of administration for patients who may not take KD enterally. Introduction Febrile infection-related epilepsy syndrome (FIRES) is a rare epileptic encephalopathy of unknown etiology which occurs in patients without active epilepsy or underlying neurological diso...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Phase 1 clinical study to assess the safety of a novel drug delivery system providing long ‐term topical steroid therapy for chronic rhinosinusitis
ConclusionLYR ‐210 is safe and well‐tolerated in ESS‐naive CRS patients and leads to sustained symptom improvement in patients.
Source: International Forum of Allergy and Rhinology - March 27, 2019 Category: Allergy & Immunology Authors: Richard G. Douglas, Alkis J. Psaltis, Joanne Rimmer, Tom Kuruvilla, Anders Cervin, Yina Kuang Tags: ORIGINAL ARTICLE Source Type: research