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Statin-Associated Necrotizing Myopathy Leading to Acute Kidney Injury: A Case Report
We present a case of a female patient who was on chronic rosuvastatin therapy and developed necrotizing myopathy. The disease progressed to acute kidney and liver injury. We discontinued the drug, started supportive measures, and initiated renal replacement therapy with a high cutoff dialysis membrane once. Her recovery was prompt, with a normal control electromyography 2 weeks after discharge.Case Rep Nephrol Dial 2021;11:129 –135
Source: Case Reports in Nephrology and Dialysis - June 17, 2021 Category: Urology & Nephrology Source Type: research

Rosuvastatin-induced rhabdomyolysis: A case report
In this report, we have also discussed the various risk factors for developing myopathy with statins and the importance of strict pharmacovigilance, and a greater caution among physicians while using this drug.
Source: Indian Journal of Nephrology - April 20, 2021 Category: Urology & Nephrology Authors: Ravindra Nikalji Suvadeep Sen Source Type: research

Opinions of nephrologists on the efficacy and tolerance of statins in hemodialysis patients.
Authors: Budzisz E, Nowicki M Abstract Large randomized controlled trials have not confirmed the effects of statin therapy on reduction of cardiovascular morbidity and mortality in end-stage kidney disease, despite that statins are still widely prescribed by nephrologists to chronic dialysis patients. The aim of the study was to analyze the attitudes of nephrologists towards statin use in hemodialysis patients. Self-designed questionnaire, containing 18 questions, was distributed among 115 nephrologists. The survey contained description of the results of 3 largest statin trials in nephrology. The questions referred...
Source: Renal Failure - November 26, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Should statins be used to prevent cardiovascular disease in patients on hemodialysis?
Abstract There now exists current evidence that the initiation of statin therapy in patients on hemodialysis does not provide the same cardiovascular benefit as in non-hemodialysis patients. The KDIGO guidelines suggest not to initiate statin therapy in hemodialysis-dependent CKD patients, but to continue therapy in patients who are already on a statin at the time of hemodialysis initiation. A closer monitoring of myopathy is warranted for hemodialysis patients on a statin therapy. PMID: 25276990 [PubMed - in process]
Source: CANNT Journal - April 1, 2014 Category: Urology & Nephrology Authors: Hoi S, Battistella M Tags: CANNT J Source Type: research

Statins side effects are minimal, study argues
ConclusionThis meta-analysis pooled results from 29 studies and has shown a very small increased risk of newly diagnosed diabetes mellitus. This is the same as the decreased risk of any cause of death in people taking statins, compared to placebo, to prevent a heart attack or stroke.The researchers point out some limitations to the meta-analysis: Each study did not report on all of the side effects, meaning that for each category of side effect, the number of participants differed. The side effect categories were only included if at least 500 people had reported suffering from it. This means there may be numerous other si...
Source: NHS News Feed - March 13, 2014 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news