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Total 1303 results found since Jan 2013.

The efficacy of CO2 angiography in the endovascular treatment of an acute iliac pseudoaneurysm
We report a case of a 39-year-old woman, allergic to iodine, with a recent kidney transplant, who presented in the emergency room with severe pain in the left iliac fossa. Angio CT-scan showed an acute pseudoaneurysm of the left common iliac artery. She was emergently treated with a stent-graft and CO<inf>2</inf> was used as main contrast medium. The intraoperative angiographies performed with carbon dioxide showed very well the rupture site and the pseudoaneurysm; the latter were more clearly visible with CO<inf>2</inf> compared with ICM. The reported case shows the efficacy of CO<inf>2</i...
Source: The Journal of Cardiovascular Surgery - August 1, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Andrea Vacirca Veronica Mirandola Gianluca Faggioli Rodolfo Pini Mauro Gargiulo Source Type: research

News at a glance: Muscular dystrophy therapy, lab-grown chicken, and humans ’ toll on wildlife
BIOMEDICINE Muscular dystrophy therapy approved The U.S. Food and Drug Administration has approved the first gene therapy for Duchenne muscular dystrophy (DMD), a genetic disease that cripples boys and usually results in death by age 30. The treatment from Sarepta Therapeutics introduces a short version of the gene for dystrophin, a crucial muscle protein, which is mutated in patients with DMD. A one-time intravenous infusion of a virus delivers the functioning “microdystrophin” gene into patients’ muscle cells. The 22 June approval is only for boys 4 to 5 years old, a group that appeared likely to ben...
Source: Science of Aging Knowledge Environment - June 29, 2023 Category: Geriatrics Source Type: research

Emapalumab as bridge to hematopoietic cell transplant for STAT1 gain-of-function mutations
Gain-of-function (GOF) mutations of transcription factor STAT1 result in overproduction of IFN- α/β, IFN-γ, and IL-27.1 This leads to immunodeficiency, autoimmune disorders, and cerebral aneurysms.2 Hematopoietic cell transplantation (HCT) is curative but has high rates of graft failure (GF), likely owing to increased levels of IFN-γ, which has been implicated in directly inhibiting hemato poietic stem cell function and also induces Fas expression and increased apopotosis.3,4,5 Emapalumab is a human IFN-γ–blocking mAb, approved for treatment of primary hemophagocytic lymphohistiocytosis.
Source: Journal of Allergy and Clinical Immunology - June 26, 2023 Category: Allergy & Immunology Authors: Binni Kunvarjee, Alan Bidgoli, Rebecca Pellett Madan, Esther Vidal, Devin McAvoy, Kinga K. Hosszu, Andromachi Scaradavou, Barbara G. Spitzer, Kevin J. Curran, Maria Cancio, Andrew C. Harris, Richard J. O ’Reilly, Andrew L. Kung, Susan Prockop, Jaap Jan Tags: Correspondence Source Type: research

Perspectives on Mycophenolate Mofetil in the Management of Autoimmunity
Clin Rev Allergy Immunol. 2023 Jun 20. doi: 10.1007/s12016-023-08963-3. Online ahead of print.ABSTRACTBefore becoming a cornerstone in the treatment of numerous immune-mediated diseases, mycophenolate mofetil (MMF) was first introduced as an immunosuppressive agent in transplant immunology and later received the attention of rheumatologists and clinicians involved in the management of autoimmune diseases. MMF is now a widespread immunosuppressive drug for the treatment of several conditions, including lupus nephritis, interstitial lung disease associated with systemic sclerosis, and anti-neutrophil cytoplasm antibody (ANCA...
Source: Clinical Lung Cancer - June 20, 2023 Category: Cancer & Oncology Authors: Rithika Bhat Antonio Tonutti Suraj Timilsina Carlo Selmi M Eric Gershwin Source Type: research

Invasive Fungal Sinusitis Risk Factors Among Immunosuppressed Hematopoietic Stem Cell Transplant Recipients
Source: International Forum of Allergy and Rhinology - June 1, 2023 Category: Allergy & Immunology Authors: Marie ‐Ange Munyemana, Anupam Pande, Dorina Kallogjeri, Nyssa F. Farrell, John S. Schneider, Peggy Kendall, Lauren T. Roland Tags: RESEARCH NOTE Source Type: research